Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 3 of 3 for “"Mtrr"”.
-
Investigating the Epigenetic Mechanism Behind Transgenerational Inheritance in Mice with Abnormal Folate Metabolism
… mutation in Methionine synthase reductase ($\it{Mtrr^gt}$). Remarkably, $\it{Mtrr^+/gt}$ heterozygosity leads to an increased likelihood of a wide spectrum of congenital malformations in their wildtype offspring for at least four generations. Folate metabolism is required for DNA synthesis and …
-
Investigating antimicrobial resistance mechanisms in Neisseria gonorrhoeae using peptide probes
… with drugs. The transcriptional regulator (MtrR) of the efflux pump, however, is a soluble protein and therefore more amenable to study and drug target validation investigations. This thesis serves to investigate the hypothesis that substrates for the MtrCDE efflux pump are also ligands for …
-
Multigenerational effects of abnormal folate metabolism on embryo growth and development
… of abnormal folate metabolism whereby the gene Mtrr was mutated causing a knockdown effect. MTRR is a key enzyme required for the progression of folate and methionine metabolism, which are important for DNA synthesis and cellular methylation. The Mtrrgt mutation disrupts folate metabolism, …