Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"Mtr4"”.
-
The Role of The Arched Helicases In Exosome-Mediated Function
… the arch domain of the nuclear exosome cofactor, Mtr4, is required for specific exosome-mediated activities and overlaps functionally with the exosome-associated exonuclease, Rrp6. Further, I show that the arch domain of Ski2 is required for the degradation of normal and aberrant mRNAs.</p> …
-
Genetic Analysis of Rna Exosome Complex Cofactors
… such as Rrp47 and the nuclear RNA helicase, Mtr4. Physicians have identified mutations in the exo-9 core in pontocerebellar hypoplasia patients (PCH), in SKIC2 and SKIC3 (the orthologs of Ski2 and Ski3) in tricho-hepato-enteric syndrome (THES) patients, and in Rrp6 in a patient with primary …
-
Functional Consequences of Rna Exosome Complex Alteration By Conformational Changes and Cofactor Binding
… to other cofactors such as an RNA helicase, Mtr4. In this study, I found that Rrp6 and Mtr4 function beyond known biochemical and structural interactions. Mtr4 seems to interact with the RNA exosome independent of the Rrp6 N- terminus. In addition, the C-terminal domain of Rrp6 has functions …
-
Functions of RNA exosome and tRNA splicing ligase in Mendelian and Infectious diseases
… with nuclear cofactors (Rrp6, Mpp6, and Mtr4), where one of the interactions is required for the essential function of the exosome. Thus, analyzing disease variants in the budding yeast model provides important insights into RNA exosome defects caused by patient-derived variants and …