Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 135 for “"Mtorc1"”.
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The localization of mTORC1 signaling
… complexes which in mammals are referred to as mTORC1 and mTORC2. While significant emphasis has been placed on defining which pathways TOR controls and on how TOR activity is set, less is known about where TOR is positioned or positions its effectors to control growth. In the work described …
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Amino acid regulation of mTORC1
Mammalian target of rapamycin complex I (mTORC1) is an atypical Ser/Thr kinase that regulates cellular and organismal growth. Accordingly, mTORC1 has substantial roles in regulating insulin sensitivity and lifespan, and when deregulated, it is implicated in the pathogenesis of common cancers. …
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Crosstalk Signaling Between cAMP and mTORC1
The mammalian target of rapamycin complex 1 (mTORC1) senses multiple stimuli to regulate anabolic and catabolic processes. G-protein-coupled receptors (GPCRs) paired to Gs proteins increase cyclic adenosine 3'5' monophosphate (cAMP) to activate protein kinase A (PKA), which phosphorylates Raptor …
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Lysosomal nutrients and the mTORC1 pathway
… of activation of the master growth regulator mTORC1 (mechanistic target of rapamycin (mTOR) complex 1), and is often deregulated in common diseases, such as cancer. Given the critical role of lysosomes in maintaining cellular homeostasis, a better understanding of lysosomal function and …
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Mtorc1 Signaling In Memory Formation and Dysfunction
<p>The mechanistic Target of Rapamycin Complex 1 (mTORC1) pathway integrates cellular availability of growth factors, energy and amino acids to regulate protein synthesis and autophagy. The mTORC1 pathway has also been shown to be required for memory consolidation, and its dysregulation is …
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A systematic approach for cataloging mTORC1 regulators
mTORC1 is a major regulator of eukaryotic cell growth. As a cellular decision-maker, mTORC1 surveils internal levels of basic biomolecules such as amino acids, ATP, cholesterol, and external levels of growth factors. Under sufficient nutrient conditions, mTORC1 is active and drives anabolic …
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Nutrient sensing by the mTORC1 pathway in physiology
… function. This coordination is achieved by mTORC1, a master growth regulator that senses and integrates a diverse array of environmental inputs, including nutrients like glucose and the amino acids leucine and arginine, whose sensing mechanisms are beginning to be identified. However, the …
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Understanding the nutrient sensing branch upstream of mTORC1
mTORC1 is a master regulator of cell growth that responds to diverse environmental inputs and is deregulated in human diseases, such as cancer and epilepsy. One important input to this system is amino acids, such as leucine, which require the Rag GTPases and its regulators, including GATOR1 and …
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Evolution of nutrient sensing in the mTORC1 pathway
The mTORC1 pathway regulates growth and metabolism in response to nutrient availability. In mammals, the mTORC1 pathway monitors the concentration of certain amino acids using dedicated nutrient sensors, which bind directly to their cognate metabolites. Unlike other components of the mTORC1 …
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Regulation of the mTORC1 growth pathway by amino acids
The mTORC1 kinase is a master growth regulator that responds to numerous environmental cues, including amino acids, to regulate many processes, such as protein, lipid, and nucleotide synthesis, as well as autophagy. Given that mTORC1 regulates a multitude of processes, it is not surprising that the …
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Integration of amino acid signals by the mTORC1 pathway
… The mechanistic target of rapamycin complex 1 (mTORC1) kinase pathway is the primary eukaryotic pathway responsible for integrating these diverse signals and coordinating cell growth programs. When activated by environmental cues that favors cell and organismal growth, mTORC1 phosphorylates …
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Mechanisms of amino acid sensing by the mTORC1 pathway
… the mechanistic Target of Rapamycin Complex 1 (mTORC1), which senses a diverse array of environmental inputs and in turn regulates nearly all aspects of growth and metabolism. Consistent with its central role in these processes, deregulation of the mTORC1 pathway is also associated with numerous …
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Regulation of mTORC1 by phosphatidic acid: mechanism and structural insight
… 1. The mammalian target of rapamycin complex 1 (mTORC1) is regulated, in part, by the endogenous inhibitor DEPTOR. However, the mechanism of DEPTOR regulation with regard to rapid mTORC1 activation remains unknown. In collaboration with Dr. Mee Sup Yoon, I discovered that DEPTOR is rapidly and …
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Discovering regulators of the amino acid sensing pathway of mTORC1
The mechanistic target of rapamycin complex I (mTORC1) protein kinase functions as a master regulator of growth, and its deregulation is common in human disease, including cancer and diabetes. mTORC1 integrates multiple environmental cues to control anabolic and catabolic processes. A key input is …
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Biochemical and physiological exploration of the nutrient sensing pathway upstream of mTORC1
The mTORC1 (mechanistic target of rapamycin complex 1) protein kinase controls growth in response to environmental cues. Aberrant mTORC1 activity is linked to numerous diseases including cancer. Understanding the regulation of mTORC1 will facilitate therapeutic developments. Amino acids promote the …
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Identification of novel proteins that regulate the amino acid-sensitive mTORC1 pathway
… kinase that, as the catalytic subunit of mTORC1, promotes growth and anabolism. Due to its central role in metabolism, the local and systemic environment surrounding the cell tightly regulate mTORC1. Growth factors and nutrients are each required to activate mTORC1 and promote growth. …
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The Role of Amino Acid Transport in the Regulation of mTORC1 by Metformin
… target of rapamycin complex 1 (mTORC1) but not safely treatable with its inhibitor, rapamycin. Here we report that in the liver, the primary target tissue of metformin, metformin regulates mTORC1 signalling by inhibiting its activation by amino acids in an AMPK-independent …
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DEPDC5 is a metabolic checkpoint regulator in the B cell AA-mTORC1 pathway
… target of rapamycin (mTOR) complex 1 (mTORC1) pathway, which is required for multiple inputs to determine if sufficient nutrients are available to drive these metabolic programs. In recent years amino acid (AA) sensing and availability have been shown to be important for the control of …
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Regulation of amino acid transport across the lysosomal surface by the mTORC1 pathway
… the mechanistic target of rapamycin complex 1 (mTORC1), which integrates various inputs such as amino acids, growth factor signaling and energy levels. Amino acids promote the localization of mTORC1 to the lysosomal surface, where it can then be activated in response to growth factor …
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TRPML1 Promotes Protein Homeostasis in Melanoma Cells by Negatively Regulating MAPK and mTORC1 Signaling
… cells to negatively regulate MAPK pathway and mTORC1 signaling. TRPML1-deficient melanoma cells exhibited decreased survival, proliferation, tumor growth, and macropinocytosis as well as serine depletion and proteotoxic stress. All of these phenotypes were partially or completely rescued by …
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