Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 183 for “"Mtb"”.
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Design of a Transforming MTB Helmet
When bicycling offroad, terrain can vary dramatically from moment to moment. As a result, experienced riders often find themselves preferring the comfort of a trail helmet in certain conditions, and the safety of a full-face mountain bike helmet in others. Presently, in order to resolve this issue, …
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Bioinformatic identification and characterization of cytokinetic regulators in Mtb
A fundamental lack of understanding of Mtb regulation during latent tuberculosis infections (LTBI), which comprises the vast majority of tuberculosis cases, has hindered global eradication efforts. To elucidate mechanisms associated with transition to the non-replicating persistent (NRP) state …
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The role of Lymphoblastic leukemia 1 (Lyl1) in Mycobacterium tuberculosis (Mtb) infection
… It is evident that Mycobacterium tuberculosis (Mtb), the causative agent for TB, is capable of developing resistance to various treatments that target the bacterium itself. Therefore, by designing therapies that directly target host factors could assist in circumventing Mtb resistance. By …
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Evaluation of diagnostic advances in Musculoskeletal Tuberculosis; the automated xpert MTB/RIF assay
Background Xpert MTB/RIF (Xpert) is a rapid, automated, onsite nucleic acid amplification test for tuberculosis (TB). It is effective for the diagnosis of pulmonary TB but there is limited evidence for its usefulness in extrapulmonary TB, particularly musculoskeletal TB. Aims and hypothesis The aim …
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Evaluation of diagnostic advances in musculoskeletal tuberculosis; the automated xpert MTB/RIF assay
The aim of this thesis was to investigate the diagnostic accuracy of Xpert for musculoskeletal TB and for rifampicin resistance against a gold standard of culture or histology. Site of disease, HIV status, and age of patients, and accuracy in spinal compared to extraspinal TB were investigated as …
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Cytotoxicity and anti-mycobacterial activities of sclerocarya birrea and Dodonae viscosa anguistifolia against MTB strain
… disease caused by Mycobacterium tuberculosis (MTB) which mainly affects the lungs causing pulmonary TB. In South Africa, the use of the Directly Observed Treatment Short Course (DOTS) strategy is applied where patients have to travel to primary Health care facilities (DOTS clinics) to get their …
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Three-Dimensional (3D) pharmacophore-based identification of possible ATP-synthase inhibitors for mycobacterium tuberculosis (Mtb)
… transmission of Mycobacterium tuberculosis (Mtb). Due to high prevalence of Mtb in South Africa, it is classified as a high burden country by the World Health Organization (WHO). Multi-drug resistant TB (MDR-TB) strains display a resistance to both Isoniazid and Rifampicin, while extensively …
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Tongue dorsum swab processing for the detection of tuberculosis with Cepheid Xpert® MTB/RIF Ultra
… sputum for detecting Mycobacterium tuberculosis (MTB) in patients with pulmonary tuberculosis (TB). Some of the most promising results have come from studies that used manual quantitative PCR (qPCR) to analyze swabs. Studies using the automated Cepheid Xpert® MTB/RIF Ultra qPCR test (Xpert Ultra) …
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Xpert MTB/RIF Ultra and mycobacterial culture in routine clinical practice at a Tertiary Paediatric Hospital
… Health Organization approved the use of Xpert MTB/RIF Ultra (Ultra) in children due to quick turn-around time, improved yield over smear microscopy, and ability to detect rifampicin resistance despite culture being the “gold standard”. This study reviewed published literature on current …
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Design and Synthesis of Inhibitors of Mycobacterium tuberculosis Menaquinone D (Mtb MenD) as Potential Therapeutics for Tuberculosis (Tb)
… energy metabolism in Mycobacterium tuberculosis (Mtb) and other Gram-positive pathogenic bacteria. Menaquinone biosynthesis presents a potential target for therapeutic intervention, as it is not produced in humans. In this work, libraries of novel inhibitor candidates targeted at the essential …
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Analysis of the use of mother tongue based-multilingual education (MTB-MLE) strategies by teachers in lower primary grades in Chongwe rural district.
… (i) to establish teachers’ understanding of MTB-MLE strategies used in the classroom. (ii) to analyse teachers’ use of MTB-MLE strategies in lower grades of Primary school. (iii) to identify the challenges that teachers face when applying MTB-MLE strategies in lower grades of primary school. …
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Analysis of the use of mother tongue based-multilingual education (MTB-MLE) strategies by teachers in lower primary grades in Chongwe rural district.
… (i) to establish teachers’ understanding of MTB-MLE strategies used in the classroom. (ii) to analyse teachers’ use of MTB-MLE strategies in lower grades of Primary school. (iii) to identify the challenges that teachers face when applying MTB-MLE strategies in lower grades of primary school. …
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Catching a glimpse: the visualization of Mycobacterium tuberculosis from TB patient bioaerosols
… tuberculosis (TB), Mycobacterium tuberculosis (Mtb). Despite this, little is known about how and when Mtb is aerosolized nor the key metabolic and morphological determinants driving successful transmission. To address these knowledge gaps, my doctoral research sought to develop a microscopic …
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Novel pathways of human host defence against Mycobacterium tuberculosis
… human resistance to Mycobacterium tuberculosis (Mtb), the primary cause of tuberculosis (TB). An improved understanding of host factors that affect Mtb clearance by macrophages, the most important cell for Mtb defence, has the potential to improve treatment regimens for TB. My thesis describes …
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Understanding host factors controlling intracellular killing of Mycobacterium tuberculosis
… to infection with Mycobacterium tuberculosis (MTB) which causes human tuberculosis (TB). Better understanding of host factors controlling the survival of MTB within the macrophage (the primary site of MTB infection) may present potentially more effective therapeutic strategies for …
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Development of Tools to Quantitatively Probe Mycobacterium tuberculosis-induced Host Phagosomal and Signaling Responses
… resistant strains of Mycobacterium tuberculosis (Mtb) necessitates new modalities for host state modulation to promote bacterial clearance. During infection with Mtb, host macrophages engulf the bacteria and sequester them in the phagosome. This interaction involves the recognition of Mtb by …
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Role of Vitamin-D3 and Retinoic Acid In A Human Thp-1 Macrophage Model of Mycobacterium Tuberculosis Infection
<p>Mycobacterium tuberculosis (Mtb) replicates within the human macrophages and we investigated the activating effects of retinoic acid (RA) and vitamin D3 (VD) on macrophages in relation to the viability of Mtb. A combination of these vitamins (RAVD) enhanced the receptors on THP-1 macrophage …
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Modular Approach for Characterizing and Modeling Conducted EMI Emissions in Power Converters
… power converters. A modular-terminal-behavioral (MTB) equivalent EMI noise source modeling approach is proposed. This work is the first to systematically develop a 3-terminal EMI noise source model for a switching phase-leg device module. Each module is modeled as pairs of equivalent noise current …
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Investigating the Double-Edged Sword of Rifampicin Resistance in Mycobacterium Tuberculosis
… by the bacterium Mycobacterium tuberculosis (Mtb), and treatment for drug-sensitive TB consists of four antibiotics taken in combination for between four and six months. Treatment is long, costly, and is often inaccessible to those in TB endemic regions of the world. This pandemic is worsened …
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Network generation and analysis for the investigation of host-pathogen interactions in tuberculosis Holifidy Arisoa Rapanoel.
… predict protein interactions between human and Mtb. The interologs method based on experimentally verified intra-species and inter-species interactions was used to predict human-Mtb protein interactions. They were further filtered using known host-pathogen interactions and genes that are …
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