Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Mst1"”.
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Molekulární mechanismy indukce programované buněčné smrti v nádorových buňkách.
… exprese C-MYC a aktivací tumor supresorové MST1 kinasy. Cnicin také snižuje expresi C-MYC, ale MST1 aktivuje pouze slabě. Artemisinin, na druhou stranu, expresi C-MYC zvyšuje a MST1 neaktivuje, indukuje tedy apoptosu nádorových buněk zcela jiným mechanismem.
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Regulation of Histone Covalent Modifications During Yeast Apoptosis
… H2B at serine 14 (H2BS14ph), catalyzed by Mst1 kinase, has been linked to chromatin compaction during mammalian apoptosis. I extended these results to yeast by demonstrating that Ste20 kinase, a yeast orthologue of Mst1, directly phosphorylates H2B at serine 10 (H2BS10ph) in a hydrogen …
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Phosphorylation Regulation of T-Lymphocyte Migration
… it is known that the signal transducer Mst1 kinase is required for T-cell polarization, adhesion, and active migration, but the underlying mechanisms remain poorly understood. I have demonstrated that Mst1 regulates two mechanical effectors, the molecular motor Myosin-IIA and the …
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Criptosistemas basados en Teoría de Grupos
… una propuesta más reciente, el criptositema MST1, del año 2000. Se demuestra que ambos esquemas son vulnerables a distintos ataques realizados utilizando técnicas de Teoría de Grupos. En el tercer capítulo de la memoria se analiza la posibilidad de cifrar mensajes utilizando problemas …
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Genetic Analysis of The Hippo Pathway In Mouse Liver
… exons in each component (<em>Mst1, Mst2, Sav1, Lats1</em> and <em>Lats2</em>). These mice were then crossed with different cre-mouse lines to generate conditional knockout mice. Results indicate a ubiquitous tumor suppression function of these components, predominantly in the …
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Study on the Physical and Functional Interaction between Fortilin and Peroxiredoxin I
… of Prx I by the serine/threonine kinase Mst1 in a dose-dependent manner. Additionally, the anti-apoptotic activity of FT under oxidative stress was found to be dependent on its interaction with Prx I. Finally, we demonstrated that a liver-specific knockout of FT exacerbates …
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Cloning and characterisation of a Dictyostelium STE20-like protein kinase DST2
… which include the mammalian STE20-like kinases (MST1/2/3), oxidant stress response kinase SOK-1, and DST1 in Dictyostelium discoideum which phosphorylates severin, a gelsolin-like F-actin fragmenting protein. DST2 was discovered by screening of the D. discoideum cDNA project database using DST1 …
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Investigating the role of the Hippo pathway in epithelial-mesenchymal transition and drug resistance
… cascade and comprises the core Hippo kinases MST1/2 and LATS1/2, which phosphorylate the transcriptional YES associated protein (YAP), promoting its nuclear exclusion and degradation. Excess YAP activity is oncogenic and is commonly observed in various human malignancies. Despite increased …
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Development of a framework for multiomic analysis in disease research
… of this PhD (including UROD, VDR, COL18A1, MST1, SCNN1B, BBS9, UMOD and MYH10). Qualitative analysis of perspectives surrounding multi-omics with participants of the 100KGP and carers identified that awareness of these technologies is low, but there is a desire to learn more, and inclusion …