Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"MscL"”.
-
Droplet Interface Bilayers for Mechano-Electrical Transduction Featuring Bacterial MscL Channels
… Escherichia Coli mechanosensitive (MS) channel MscL, when incorporated within a droplet interface bilayer (DIB). The activity of MscL channels in an artificial DIB system is demonstrated for the first time in this document. The DIB represents a building block whose repetition can form the basis …
-
Molecular Dynamics Studies of the *Gating Mechanism of a Mechanosensitive Channel
… to tension in the membrane. One such channel, MscL, poses an especially interesting challenge to modelers both because the channel is activated by membrane tension alone, and because the transition to the open state necessarily involves an unusually large conformational change from a leakproof …
-
Exploring the Dynamics of Mechanosensitive Channels Utilizing a Post Translational Modification Approach
… mechanosensitive channel of large conductance (MscL) and the mechanosensitive channel of small conductance (MscS), from E. coli, have been the most studied mechanosensors to date. These channels coordinate a response to rapid changes in osmolarity to serve as emergency release valves during an …
-
Determining Structural Transitions That Occur Upon Gating a Bacterial Mechanosensitive Channel
… mechanosensitive channel of large conductance (MscL) is one of a handful of channels that responds to tension in the membrane and acts as a lifesaving mechanism for the cell in instances of osmotic down shock. Solutes are jettisoned before the cell explodes due to internal pressures. The goal of …
-
Nanopores for detecting and sensing biological molecules
… conductance. We introduced and simulated MscL (Mechano-Sensitive Channel of Large Conductance) as an alternative to traditional biological nanopores (Alpha-Hemolysin, MspA) since it provides a flexible nanopore with adaptability to DNA base types. Induced tension in MscL is shown to be …
-
Multi-Symplectic Integrators for Nonlinear Wave Equations
… by a multi-symplectic conservation law MSCL). Then multi-symplectic integrators (MSIs) are numerical schemes that preserve exactly the MSCL. Remarkably, we demonstrate that, although not designed to do so, MSIs preserve very well other associated local conservation laws and global …
-
Molecule transport in nanopores with applications to water purification, power generation and disease diagnosis
… Mechano-Sensitive Channel of Large Conductance (MscL) protein pore opens for single stranded DNA (ssDNA) translocation under an applied electric field. As each nucleotide translocates through the pore, a unique mechanical signal is observed – specifically, the tension in the membrane containing …
-
Regioselective chlorination of cellulose esters
… chlorinate cellulose esters using MsCl. Compared to bromination of cellulose typically used, this chlorination method has many advantages, including low cost of reagents and ease of separation. The chlorinated cellulose esters are useful intermediates for appending new …
-
Ion current modulation in bio-mimetic channel systems
… gating mechanism and a mechanosensitive channel (MscL) gated by thermo-mechanical sensitive ABA copolymer membrane. These works represent potential applications of drug delivery engineering. The nanopore sequencing system by using various mutant CsgG to sense different DNA sequences. Several …