Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"MsbA"”.
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On the mechanisms of substrate translocation by the ABC transporter MsbA
… of polyspecific drug efflux pumps in cells. MsbA is an ATP-binding cassette (ABC) protein in Gram-negative bacteria that can mediate the efflux of a wider range of antibiotics but also mediates the flopping of phospholipids and Lipid-A core across the plasma membrane. The MsbA protein has a …
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On the mechanisms of transport and energy coupling in ABC exporters
… Escherichia coli lipid A/multidrug ABC exporter MsbA. Current alternating access models for ABC exporters involve cycling between conformations with inward- and outward-facing substrate-binding sites in membrane domains (MDs) in response to engagement and hydrolysis of ATP at the …
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Investigations into the Lipid Transport Mechanisms and Energetics of Bacterial ATP-Binding Cassette (ABC) Transporters MsbA and LmrA
LmrA and MsbA are two paradigms in research on multidrug ATP-binding cassette (ABC) transporters. The bacterial transmembrane protein LmrA from *Lactococcus lactis* was the first known prokaryotic ABC transporter homologue of the mammalian multidrug resistance transporter ABCB1 (P-glycoprotein) …
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The development of stapled peptides as chemical tools to investigate activin A signalling and as antibacterial agents targeting MsbA-mediated efflux
… peptides as antibacterial agents targeting MsbA- mediated efflux Antimicrobial resistance (AMR) is a significant threat to global health and Gram-negative bacteria are a particularly challenging target. MsbA is an essential transmembrane protein in Gram-negative bacteria, transporting the …
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Novel Strategies towards the Inhibition of ATP-Binding Cassette (ABC) Transporters from Pathogenic Bacteria
… Two examples are the essential lipid transporter MsbA, from *Escherichia coli* and other pathogenic Enterobacteria, and the multidrug efflux transporter PatAB, that is upregulated in fluoroquinolone resistant *Streptococcus pneumoniae*. These proteins primarily utilise nucleotide hydrolysis to …
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Business English for international graduate students: A survey of ESL 505
… Masters of Science in Business Administration (MSBA) and Masters of Science in Finance (MSF) programs. In order to ensure that ESL 505 is a positive experience, a periodic review of the goals, objectives and output of the course is recommended. Therefore, the goal of this study is to answer two …
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The Perceived Healthy Practices Of School Board Governance: Strategic Planning And Decision Making To Impact Student Achievement
… and the Minnesota School Board Association (MSBA). The NCLB Act, as it relates to school board governance, was designed to increase levels of student achievement by focusing on a process of collaboration among and between the school board members, the superintendent, parents, teachers, and …