Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Mpeg1"”.
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The role of a pore-forming protein, Mpeg1, in cytosolic import
… import. With this approach we identified Mpeg1, as a potential player in cytosolic import in DCs. Mpeg1 is a member of the membrane attack complex/perforin (MACPF) superfamily. We find that DCs deficient in Mpeg1 are less efficient in their ability to import saporin into the cytosol, and …
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Characterization of endocytic escape pathway and its role in adaptive immunity
… strong hit: pore-forming protein, perforin-2 (*Mpeg1*; Macrophage-expressed gene 1) and we proposed perforin-2 forms pores in endolysosomal compartments, allowing for endocytic escape of saporin. The main aim of my PhD was to extend our understanding of mechanisms governing endocytic escape …
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Assessing the impact of domoic acid exposure on the zebrafish (Danio rerio) brain across life stages
… or infection. Using transgenic zebrafish (Tg(mpeg1:mCherry)), I characterized developmental windows of microglial sensitivity to DA exposure. Developmental exposure to DA (0.1 ng/embryo) at 2 days post-fertilization (dpf) resulted in microglial reactivity without permanent gross morphological …