Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 50 for “"Movement Disorder"”.
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A qualitative exploration of the movement disorder experience
… entitled ‘A qualitative exploration of the movement disorder experience’ explores both the experience of diagnosis of several, and the lived experience of one specific, common movement disorders. Section One presents a meta-synthesis of 24 research papers, each of which explores the …
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EEG Characterization During Motor Tasks That Are Difficult for Movement Disorder Patients
<p>Movement disorders are a group of syndromes that often arise due to neurological abnormalities. Approximately 40 million Americans are affected by some form of movement disorder, significantly impacting patients’ quality of life and their ability to live independently. Deep brain stimulation …
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Psychometric validity for the Matson Evaluation of drug side effects and the akathisia rating of movement scale
Akathisia is a movement disorder characterized by a sense of restlessness and increased motor activity. Movement disorders are primarily an iatrogenic result of mediation use. In the case of akathisia, this syndrome is easily misdiagnosed as a psychiatric disorder. As a result, there is a need to …
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Electrophysiological Analysis in an Animal Model of Dystonia
Dystonia is a movement disorder characterized by patterned, repetitive, and sustained muscle contractions that cause ineffective and often painful movements. The overall goal of this project was to understand the physiological mechanisms of dystonia in a rodent model as a basis for developing …
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AUTOANTIGENS IN PARKINSON'S DISEASE
Parkinson’s disease (PD) is a debilitating movement disorder characterized by the loss of dopaminergic neurons in the substantia nigra. Little is known about the role of autoimmunity in PD pathogenesis. This thesis examines the role of two autoantigens, α-synuclein and the stress inducible …
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Deep Brain Stimulation for Tourette Syndrome
… in 2016. These data nonetheless should encourage movement disorder groups to consider treating refractory TS with DBS. The development of standardized surgical criteria will be helpful for identifying appropriate patients for evaluation.
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Electromyographic Characterization in an Animal model of Dystonia
… been utilized to systematically investigate the movement disorder. In the present study, spontaneously jaundiced (jj) 16 day old Gunn rat pups were treated with sulfadimethoxine to exacerbate bilirubin neurotoxicity and compared to saline treated jjs and non-jaundiced (Nj) littermates. …
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Effect of maternal separation on stress-related proteins measured in a 6-hydroxydopamine rat model of Parkinson’s disease
… a rat model of Parkinson’s disease (PD). PD is a movement disorder resulting from the selective degeneration of dopamine neurons in the substantia nigra pars compacta (SNc). Dopamine neurons have been shown to exhibit mitochondrial dysfunction, oxidative stress and misfolded protein aggregation in …
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The Impact of Sleep Disorders on Driving Safety - Findings from the SHRP2 Naturalistic Driving Study
… on the association between seven types of sleep disorder and driving risk using large-scale naturalistic driving study data involving more than 3,400 participants. Regression analyses revealed that females with restless leg syndrome or sleep apnea and drivers with insomnia, shift work sleep …
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The Effects of Parkinson's on Fixational Stability
… disease (PD) is a progressive, neurological movement disorder. The stability of eye movements in PD is not well understood but many patients report difficulty doing tasks that require stabilized fixation and gaze. The ability to stabilize an image on the retina is critical is acquiring visual …
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Hybrid System Identification of Manual Tracking Submovements in Parkinson's Disease
… a joystick input) are actually sequences of submovements: short, open-loop motions that have been previously learned. In Parkinson's disease, a neurodegenerative movement disorder, characterizations of motor performance can yield insight into underlying neurological mechanisms and therefore into …
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Magneto-rheological fluid orthosis for suppressing tremor
Tremor is a common movement disorder that occurs with specific neurological conditions. This condition may seriously impact daily living activities. The aim of the present study is to evaluate the possibility of the development of a wearable technology that is capable of exerting torques at a …
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The Yips: A Phenomenological Investigation into the Experience of a Lost Movement
… lose the ability to perform a basic, habitual movement of their sports. There is a growing body of research which frames the yips as a movement disorder with possible physical or psychological etiologies, or with components of both. This study centers on the experiences of athletes with the …
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Alternating Current Stimulation for Essential Tremor
Essential tremor is the most common movement disorder, characterized by involuntary rhythmic shaking of the hands, head, trunk, vocal cords, or legs. While the pathophysiological mechanisms of essential tremor are not fully understood, research suggests the involvement of a complex network called …
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Neuroimaging investigation of the motor control disorder, dystonia with special emphasis on laryngeal dystonia
… is the focal laryngeal form of the neurological movement disorder called dystonia, a condition that often changes in severity depending on the posture assumed and on voluntary activity of the affected body area. Pathophysiology of dystonia is unknown. This thesis employed a combination of …
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Neurochemical Measurements in Rodents that Model Huntingtion's Disease and Oxidative Stress
… disease (HD) is a fatal, neurodegenerative movement disorder caused by a CAG repeat expansion on the gene encoding the huntinin protein. HD is characterized by preferential and extensive striatal degeneration. We used fast-scan cyclic voltammetry to measure dopamine release and reserve pool …
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Effect of high intensity interval training on Parkinson's disease
… a control group. Symptoms will be scored on the movement disorder society’s unified Parkinson’s disease rating scale (MDS-UPDRS) at baseline, throughout and after treatment and further analyzed to see if there is clinical significance in using this type of exercise in this population. If HIIT …
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DJ-1, a Parkinson’s Disease-associated Gene, Prevent Excessive Glial Inflammatory Responses through Interaction with SHP-1
… disease (PD) is a progressive neurodegenerative movement disorder caused by the death of dopaminergic neurons in the substantia nigra. Importantly, altered astrocyte and microglial functions could contribute to neuronal death in PD. In this study, I demonstrate a novel mechanism by which DJ-1 …
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Parkinson's Disease Automated Hand Tremor Analysis from Spiral Images
… is a progressive disease, impacting a person’s movements and thought processes. In recent years, computer vision and machine learning researchers have been developing techniques to aid in the diagnosis. This thesis is motivated by the exploration of hand tremor symptoms in Parkinson’s patients …
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Molecular genetic characterization of ataxic movement disorders in mouse and human
… type 1 was identified to underlie a severe movement disorder in mice. The 18bp in frame deletion in Itpr1 exon 36 was shown to be allelic to that of another model, opisthotonos (Lane 1972). The Itpr1Δ18 mutation leads to a decreased to almost total lack in the normally high level of ITPR1 …
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