Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"Mouse tumor model"”.
-
Engineered Anti-CD40 Agonist Antibody for Cancer Vaccine Delivery
… immune responses. We synthesized an anti-mouse CD40 agonistic–monovalent streptavidin fusion antibody (αCD40-mSAs), which enables targeted delivery of biotinylated neoantigen peptides to APCs in draining lymph nodes (dLNs). αCD40-mSAs were validated for mSA expression and demonstrated …
-
Nanomaterials for the detection of cancer-associated biomarkers
… thesis focuses on optical detection of prostate tumors through the development of biomarker-targeted molecular imaging probes. In the first part of this work, engineered human prostate cancer cell lines were developed and characterized to determine the dynamics of post-translational processing …
-
Multifunctional CuS Nanoparticles for Imaging Guided Photothermal Ablation Therapy
… tested in HepG2, HEK293 and U87 cell lines. The tumor binding activity and the photothermal effect for the targeted CuS NPs was evaluated in U87 cells. PET/CT imaging, biodistribution and PTA therapy were performed in a U87 xenograft mouse tumor model. For the doped NPs, the elements …
-
The Cytoplasmic Tail of Mhc Class I Molecules Plays A Critical Role In Dendritic Cell-Induced T Cell Immunity
… MHC-I cytoplasmic tail isoforms in both mouse and human DCs. These DCs were then used as vaccines in a melanoma mouse tumor model and in a human invitro co-culture system.</p> <p>In this thesis, we show that DCs expressing exon 7-deleted MHC-I molecules, stimulated remarkably higher …
-
Tumor cell deformability in the metastatic cascade
During the process of metastasis, tumor cells must undergo changes that enable them to detach from a tumor, exit surrounding tissue during intravasation, enter into circulation and eventually stop at a distant site for extravasation. Here, we measure the physical changes in the deformability of …
-
Ionizing Radiation and Endostatin Gene Therapy Against Lung Tumor
… many advances have been made in radiotherapy, tumor radioresistance and normal tissue damage continue to always be important issues for radiation oncologists. Numerous reports have also documented that radiation exposure increases the risk for malignancy and suppresses immune mechanisms. …
-
Targeting mdr1 and endocrine therapy-resistant cancers through estrogen receptor
… and endometrial cancer cells. Moreover, in a mouse xenograft, BHPI treatment resulted in rapid and substantial regression of pre-existing tumors. Extending the novel action of BHPI by hyperactivating anticipatory UPR, a new approach to inactivating multidrug resistance protein 1 (MDR1) in …
-
Factors Influencing Topotecan CNS Penetration in Mouse Models
… currently tested in clinical trials for brain tumors. However the clinical outcome is far below the expectations, which are derived from the promising preclinical studies. This discrepancy could be partially attributed to the presence of two barrier systems in the brain, the blood brain barrier …