Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 20 for “"Mouse studies"”.
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The Genetic Basis of Obesity
… of obesity however, has led to numerous studies focused on understanding the genetic basis of this complex disorder. To this effect, this thesis summarizes the current knowledge of obesity genetics, including the monogenic, polygenic and epigenetics field. Given the tremendous …
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Preclinical Investigations Of Genetic Correlates Of Alcohol Use Disorder
… to characterize its genetic basis. Preclinical studies have been critical in describing the functional significance of genes associated with AUD and have advanced our understanding of the neurobiological underpinnings of this disorder. This dissertation presents a collection of mouse studies …
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Identification of a first in-class integrin enhancing small molecule for the treatment of Duchenne Muscular Dystrophy
… the skeletal muscle of DMD patients and the mdx mouse model. Previous pharmacological and transgenic mouse studies have demonstrated that the α7β1 integrin is a major modifier of disease progression in mouse as well as the Golden retriever dog models of muscular dystrophy. Therefore, we …
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Dosimetry of ¹²⁵Iodine protons for in vivo mouse irradiation study
… to this dose level, and can be used in future mouse studies to determine dose rates at other orders of magnitude.
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Biomechanical and Molecular Approaches to Aortic Valve Disease in a Mouse Model
… using the elastin haploinsufficient (Eln+/-) mouse. Studies from our lab have established this mouse as a model of aortic valve malformation with latent AVD. The central hypothesis of the proposed research is that elastin haploinsufficiency in aortic valve tissue causes increased valve …
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The Balance of Interferon-γ and Interleukin-10 during Influenza A Virus Infection Complicated by Methicillin-Resistant Staphylococcus aureus Superinfection
… prompted by interferon (IFN)-γ. Transgenic mouse studies demonstrate that IFN-γ receptor (IFN-γR) signaling in mononuclear phagocytes induces tumor necrosis factor (TNF)-α hyperproduction and lethal inflammatory lung damage, with no detectable benefit to viral or bacterial clearance. In …
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The human factors of computer input using a mouse device
… select items from a computer display using the mouse input device. The term computer mouse refers to a class of input devices which share certain features, but these may have different characteristics which influence the ways in which people use the device. Although task completion time is one …
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SPAG16 is a Bifunctional Gene Regulating Male Fertility
… from general axoneme formation. Transgenic mouse studies published previously by our lab have shown that abrogation of both SPAG16 isoforms causes arrest of spermatogenesis, and the mutant allele is not transmitted to offspring by chimeric males. Mice homozygous for a knock-out of SPAG16L …
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Tuberculosis transcriptomics: host protection and immune evasion mechanisms
… in vitro macrophage assays and in vivo knockout mouse studies. The data in this thesis showed that basic leucine zipper transcription factor 2 (Batf2) was an important factor that regulates inflammatory responses in Mtb infection. Deletion of Batf2 led to the survival of mice with reduced lung …
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Reconstruction Methods for Optical Molecular Tomography
… enable preclinical applications such as cancer studies, involving angiogenesis, tumor growth, cell motility, metastasis, and interaction with a micro-environment. The reconstruction of diffuse light sources is the central task of optical molecular tomography, and generally ill-posed and rather …
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Characterizing the Role of TLX1 in T-cell Acute Lymphoblastic Leukemia
… of oncogenic transformation3,4. While transgenic mouse studies have established the causative role of primary oncogenic TFs in driving leukemia, the mechanisms through which these proteins contribute to disease progression remain unclear. One subtype of T-ALL, representing 11% of T-ALL cases, is …
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Structure-activity relationship studies and biological evaluation of selective sphingosine kinase inhibitors
… become a prevalent drug discovery target due to studies implicating it to several disease pathologies such as fibrosis, sickle cell disease, inflammation, diabetes, and cancer. S1P functions to induce cell proliferation and migration. S1P signaling occurs through intracellular targets or …
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PRC2 GATEKEEPS THE BALANCE BETWEEN DIRECT AND INDIRECT NEUROGENESIS AND CONTROLS NEURONAL MIGRATION DURING HUMAN CORTICOGENESIS
… changes, remains limited and primarily based on mouse studies. To better understand the molecular mechanisms underlying WVS, we conducted comprehensive transcriptomic and epigenomic analyses of patient-derived cortical brain organoids (CBOs) cultured for up to 250 days in vitro. Our multi-omic …
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From Phenotype to Genotype: Discovery of New Molecular Primary Immunodeficiencies
… genome sequencing and genome wide association studies to analyze the UK cohort of predominantly antibody-deficient patients, we identified PTPN2 and SOCS1 haploinsufficiency due to a combination of common and rare variants as genetic causes of CVID. These patients had loss of TC-PTP and SOCS1 …
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A Reductionist Approach to Modeling Human Corticogenesis
… basis of cortical development comes largely from mouse studies due to the genetic tractability of this model system. However, as primate studies have shown, the primate brain is unique in terms of its progenitor and neuronal composition, cortical areas, scale, and gene expression. Limitations in …
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Role of the NLRP3 Inflammasome in bacterial keratitis
… that play important roles in inflammation. Studies have reported that the NLRP3 inflammasome is activated in response to infection with Pseudomonas aeruginosa (P. aeruginosa) and Staphylococcus aureus (S. aureus). However, the role of NLRP3 inflammasome in the pathogenesis of bacterial …
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Extrapancreatic actions of incretin-based therapies on bone in diabetes mellitus
… SaOS-2 cells, and also preliminary in vivo studies on the impact of genetic deficiencies of GIPRs and GLP-1Rs on bone mineral density and content. Further studies characterised the beneficial effects of incretin-based therapies on metabolic control, bone microstructure and bone mechanical …
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Mapping the Gut Microbiota and its Protective Functions Against Bacterial Enterocolitis
… models for achieving this. Despite this, the mouse gut microbiota is poorly characterised compared to humans, limiting translation of research between these hosts. This thesis describes the generation of the largest and most comprehensive catalogue of high-quality mouse gut-derived genomes to …
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Cellular and synaptic pathophysiology in a rat model of Fragile X syndrome
… mental retardation protein (FMRP). Animal model studies over the past twenty years, mainly focusing on the Fmr1 knockout (KO) mouse, have uncovered several cellular and behavioural phenotypes associated with the loss of FMRP. Seminal work using the Fmr1 KO mouse found that metabotropic glutamate …
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Defining the role of toll-like receptor 10 in immune signaling
… lines and transgenic mice was used, and these studies revealed an inhibitory role for TLR10 in the context of pro-inflammatory cellular responses to numerous TLR ligands. The effect of TLR10 in abrogating both MyD88 and TRIF dependent signaling was discovered using transient transfection …