Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 83 for “"Mouse strains"”.
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Peripheral Taste System in Inbred Mouse Strains
Taster and non-taster mice strains have been used extensively in animal taste research. Inbred mouse strains C57 and FVB have been proposed to be tasters, where as strains 129 and Balb/C are classified as non-tasters. Therefore, evaluating the peripheral taste system in these mice is of great …
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Analysis of variation in PIWI-interacting RNA (piRNA) expression in testes of different mouse strains
… of piRNAs in the male germline of five inbred mouse strains. We tested for variation in piRNA expression between different mouse strains. Furthermore, we tested whether variation in transposon copies between mouse strains affects the expression of piRNAs. We analyzed piRNA expression from …
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Defining How Polymorphisms at the Slam Family Locus Affect NK and T Cell Function
… two stable haplotypes found in common laboratory strains of mice. The b haplotype is found in all C57-derived mouse strains, and the z haplotype is found in all non-C57 derived mouse strains, including many autoimmune mouse strains. The SLAM family of receptors, which includes CD244, Ly108, CD84, …
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Guanabenz Reduces Hyperactivity and Neuroinflammation Caused by Latent Toxoplasmosis in Mice
… reverses behavioral changes. We used two mouse strains (BALB/c and C57BL/6) differing in their susceptibility to infection. Following drug treatment of chronically infected mice, locomotor activity in an open field was assessed. In both mouse strains, the increased hyperactivity seen …
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Determination of the role of cytokines using gene deficient mice in African trypanosomiasis infection
… mice were used. While the two latter mouse strains lack all IL-12 homologues, IL-12p35¯/¯ mice still produce IL-12p80 homodimers and IL-23. In infection with T.b. brucei and T.evansi; IL-12p35¯/¯, IL-12p40¯/¯ or IL-12p35¯/¯/p40¯/¯ mice were susceptible to both these pathogens, …
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The Genetic Basis of Susceptibility to Therapy-related Leukemia in Mice
… candidate risk factors, cohorts of twenty inbred mouse strains were treated with N-ethyl-N-nitrosourea (ENU), a potent alkylating agent in mice. Six of these mouse strains were susceptible to alkylator-induced leukemia. SWR/J mice were the most susceptible in this relatively small screen. We …
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INVESTIGATION OF GENETIC FACTORS DETERMINING ISCHEMIC STROKE OUTCOME
… permanent, focal cerebral ischemic stroke mouse model to investigate genetic factors of ischemic stroke outcome measured by infarct volume. This model is the middle cerebral artery occlusion (MCAO) model. First, we screened infarct volumes across 32 inbred mouse strains. The infarct volume …
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Genetic Effects Mediated Through Epistatic Networks Onto Metabolic Traits
… advanced intercross of the LG/J and SM/J inbred mouse strains to unravel the genetic architecture of multiple metabolic traits. These studies found that parent-of-origin effects are surprisingly common, and that they can be mediated by the environment. This indicates that our ability to predict …
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Heritable variation in reward sensitivity and impulsive cction and choice in a genetically diverse inbred mouse panel
… The Collaborative Cross (CC) recombinant inbred mouse strains and their inbred founders are a powerful genetic reference panel that has potential as a tool for revealing genetic correlations. The CC/DO founder strains were used to examine the heritability of reward sensitivity and impulsivity …
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CONTRIBUTIONS OF THE 3' HOX GENES, HOXA1, HOXB1, AND HOXB2, TO PATTERNING OF THE AXIAL SKELETON DURING DEVELOPMENT
… heterozygotes. Through the use of transgenic mouse strains, we were also able to reproduce similar transformations upon addition of extra HoxB gene copies. Interestingly, the defects observed in these loss-of-function mutants and transgenic mice occur at the boundaries between morphologically …
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Plasticity in mice nociceptive spinal circuits -role of cell adhesion molecules.
… to the spinal cord and plastic mechanisms in the mouse and rat. On this basis, the role of adhesion molecules, in particular L1 adhesion molecules, in the nociceptive system is analyzed for the first time by using mutated mice. Results: It is confirmed that sensorimotor transformations performed …
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Narrowing of the SLES1 Internal Reveals Complex Epistatic Interactions in the Suppression of Autoimmunity
… systemic autoimmunity derived from the NZM2410 mouse strain. The NZW-derived suppressive modifier locus, Sles1, specifically prevents the spontaneous loss in tolerance mediated by the B6.Sle1 congenic. Sles1 had previously been fine-mapped to a remarkably gene-rich region on murine chromosome 17 …
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Body Temperature and Diet As Drivers of Obesity Development
… third project, we generate two novel knock-in mouse strains, which can be utilized in future research to gain mechanistic insight into the causes of leptin resistance in obesity. Together, these three projects advance the understanding of how body temperature and diet drive obesity development …
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Functional Analysis of Genomic Variation and Impact on Molecular and Higher Order Phenotypes
… the genome of one of the oldest inbred strains of mice—DBA/2J—the father of the large family of BXD recombinant inbred strains. We analyzed ~100X wholegenome sequence data for the DBA/2J strain, relative to C57BL/6J, the reference strain for all mouse genomics and the mother of the BXD …
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Pathological and genetic analysis of host susceptibility to cardiovirulent coxsackievirus B3 infection in mice
… traits were characterized. Three inbred strains of mice and two congenic strains were infected with CVB3. Differences in survival, body weight loss, quantification of myocarditis and quantification of sarcolemmal disruption were found by comparing three sets of mice sharing the same H-2 …
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THE CHARACTERIZATION OF BEHAVIORAL ABNORMALITIES IN BDNF LOXP TRANSGENIC MICE
… mice (BDNF<sup> lox+/+</sup>) are a transgenic mouse strain used to study the neurotrophin brain-derived neurotrophic factor (BDNF) through Cre-Lox recombination when crossed with the appropriate Cre-expressing strain. BDNF<sup> lox+/+</sup> mice contain two artificially inserted LoxP sites …
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RNA sequencing for the study of gene expression regulation
… gene expression and of isoform usage between mouse strains. I demonstrate that gene expression diverges extensively between the strains and propose that the regulatory mechanism underlying divergent expression between two closely related mammalian species is a combination of variants that …
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Bone Tissue Quality Determination of Mice Through a Novel Reference Point Indentation Technique
… in fracture toughness that exist between inbred mouse strains with genetically based differences in mineralization. To achieve this we measured a new parameter called Indentation Distance Increase (IDI) which has been shown to be related to fracture toughness. We also analyzed associated …
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Deciphering the Pathogenesis of Acute Myeloid Leukemia
… not fully understood. To address this, knockin mouse strains harboring different Cebpa mutations and Flt3-ITD were used to generate an AML mouse model. This model demonstrated a block at the transition from pGMP to GMP due to disrupted C/EBPα function. The cooperative effect of FLT3-ITD is …
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