Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Mouse models of cancer"”.
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Identification and Characterization of Modulators of Chemotherapeutic Response in Mouse Models of Cancer
Chemotherapeutic drug resistance is a major cause of cancer treatment failure. While much attention has been focused on the genetics of tumor development, less is known about the genetic determinants of therapeutic outcome. As a central focus of my graduate work, I have employed pool-based …
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An optofluidic platform for longitudinal circulating tumor cell studies in mouse models of cancer
… process that is responsible for over 90% of cancer-related deaths. Circulating tumor cells (CTCs) that are shed from primary tumors represent the disseminating "seeds" that give rise to distant malignant growths. Despite their importance to metastasis, understanding of their role has been …
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Investigation of T cell-mediated immune surveillance against tumor-specific antigens in genetically engineered mouse models of cancer
The association of tumor cells and lymphocytes has led to the hypothesis that our immune system actively inhibits the formation and progression of cancer, a phenomenon called tumor immune surveillance. T cells specific to mutant proteins have been identified in cancer patients and the recent …
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Insights into determinants of cancer susceptibility, initiation, and progression:studies on medulloblastoma and Histiocytic Sarcoma in mouse models
This dissertation presents a discussion of both perigestational dietary influence on cancer predisposition as well as somatic genetic determinants of cancer development. Both projects used genetically engineered mouse models of cancer. The introductory chapter gives a brief historical introduction …
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Imaging Biomarkers of Response to Immune Checkpoint Inhibition in Melanoma
… against tumours has been used in the management of several malignancies including metastatic melanoma. Although preliminary studies in patients with untreated metastatic melanoma demonstrated significantly increased progression-free survival, there is an unmet need for clinical decision-making …
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Arid1a Haploinsufficiency Initiates Neural Crest Transformation in a Mouse Model of Mycn-driven Neuroblastoma
Mouse models of cancer are critical for developing therapeutic treatments for pediatric patients. Recent sequencing studies of neuroblastoma (NBL) patient tumors have uncovered precise deletions in the chromatin remodeler and tumor suppressor gene (TSG) ARID1A. Additional causal studies supported …
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Constructing and deconstructing cancer using CRISPR-Cas9
Cancer is a genetic disease that arises through the sequential acquisition of genetic and epigenetic alterations in oncogenes and tumor suppressor genes. Large-scale efforts to re-sequence protein-coding genes from human cancer cell lines and tumor biopsies have begun to catalog the spectrum of …
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AN INQUIRY OF THE SR/CR MOUSE PHENOTYPE AND ADVANCES REGARDING THE SEARCH FOR AN ANALOGOUS HUMAN TRAIT
… our laboratory observed the unique occurrence of cancer resistance in a single BALB/c mouse. Subsequent breeding studies found that this trait, known as Spontaneous Regression/Complete Resistance (SR/CR) is heritable among 30 to 40 % of offspring in an autosomal manner, thus enabling extensive …
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Re-Designing Cancer Immunotherapy to Enhance Anti-Tumor Immunity
Immunotherapy has transformed the field of oncology. However, clinical challenges of toxicity and low response rate offer opportunities to develop novel, rational strategies to integrate into current clinical oncology treatment. To address these challenges, we designed a novel local mesenchymal …
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Identifying Epigenetic Regulators Of Tumor Dormancy And Recurrence
Part 1: Breast cancer remains the leading cause of cancer mortality in women, largely due tometastatic recurrence. Recurrent tumors arise from residual tumor cells, which can survive cancer therapy and stay dormant for an extended period of time. Despite their clinical importance, the biology of …
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Synthesis and biological evaluation of structurally diverse indole-based analogues as inhibitors of tubulin polymerization and synthesis of drug-linker constructs cleavable by enzymes present in the tumor microenvironment.
A sub-set of inhibitors of tubulin polymerization that bind to the colchicine site demonstrate dual functionality as both potent cytotoxins (antiproliferative agents) and effective vascular disrupting agents (VDAs). Our previous studies led to the discovery of a potent inhibitor of tubulin …
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Detecting tumour responses to treatment using metabolic imaging with hyperpolarised [1-13C]pyruvate and 2-([18F]fluoro)-2-deoxy-D-glucose
Earlier detection of tumour responses to treatment would facilitate modification of treatment regimens and reduce unnecessary side effects and the costs of ineffective therapy. Anatomical changes following treatment are often slow to manifest and are occasionally misleading. Molecular imaging …
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Examining cancer metabolism in vivo
Nutrient requirements for cancer cells are different from those of most normal cells. Understanding these differences, and the factors that are responsible for creating different metabolic dependencies, is critical to understanding the basic requirements of rapid proliferation and identifying …
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Goggle Augmented Imaging and Navigation System for Fluorescence-Guided Surgery
… option for most solid tumors. The standard-of-care usually involves tumor resection and sentinel lymph node biopsy for cancer staging. Surgeons rely on their vision and touch to distinguish healthy from cancer tissue during surgery, often leading to incomplete tumor resection that …
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Tumor Angiogenesis is all Tied up in Tie2-Expressing Macrophages
The impact of the immune system on solid tumor formation and malignant disease has been the focus of much study over the last several decades. Elimination of macrophages from mouse models for malignancy result in decreased in tumor angiogenesis, progression and malignancy. Further migration of …
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Identification & characterization of natural and synthetic compounds as new anticancer agents
… to set up and maintain primary cell cultures and cancer derived cell lines as well as to evaluate the cytotoxicity of potential novel synthetic inhibitors of human cancer cells. Part of the second and all the third year was spent at the University of Cape Town, South Africa, in the laboratory of …
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Engineering therapeutic proteins for immune modulation
… is implicated in the efficacy, to some degree, of most anti-cancer monoclonal antibodies. This interaction is mediated through Fc gamma receptor (Fc[gamma]R) binding to the antibody Fc. Activating and inhibitory Fc[gamma]Rs are expressed on immune cells and bind to the Fc regions of IgGs, which …
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Treatment of murine tumors with recombinant Myxoma viruses
Oncolytic viruses are designed to be novel cancer treatments that not only specifically target cancer cells, but can act as vectors to express proteins of interest within the tumor bed. Myxoma virus (MYXV), a rabbit-specific poxvirus, was evaluated as an oncolytic viral treatment for cancer in …
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HISTONE LYSINE METHYLTRANSFERASE NSD3 GOVERNS TRANSCRIPTIONAL PROGRAMS THAT DRIVE PANCREATIC NEUROENDOCRINE TUMORS (PANNETS)
… for PanNET patients. Additionally, pre-clinical models that more accurately represent disease are an urgent necessity for translational studies.</p> <p>This dissertation directly addresses these challenges by identifying histone lysine methyltransferase (KMT) NSD3 as a critical oncogenic driver …
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NEUROFIBROMATOSIS TYPE 2 PROTEIN (NF2) AS A REGULATOR OF TUMOR SUPPRESSORS AND VIRAL ONCOPROTEINS IN HUMAN GLIOBLASTOMA
… Several obstacles have prevented the development of efficacious treatment strategies. Due to the insidious nature of these malignancies, tumors are not typically detected until late in the disease. Further, the delicate nature of surrounding normal brain tissue makes surgery and treatment with …