Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 834 for “"Mouse models"”.
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MOUSE MODELS OF IMMUNODEFICIENCY
… the extensive employment of immunodeficient mouse models, their immune status is seldomly assessed by the research community, with possible unexpected and misleading results from the experiments. Furthermore, no standardized system for such assessment currently exists. This calls for the urge …
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Mouse Models of Inherited Skin Diseases
… in the palmoplantar epidermis. Here, a K9-null mouse was generated to define the functional importance of KRT9 (Krt9 in mice) in the palmoplantar epidermis, and determine the extent to which silencing is therapeutically viable. Krt9-/- mice developed epidermal fragility phenotypes localised to …
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Glutamate Imaging of Mouse Models of Neurodegeneration
… pathology induced changes in glutamate levels in mouse models of neurodegeneration using a novel magnetic resonance imaging technique, glutamate chemical exchange saturation transfer (GluCEST) imaging. Several studies were performed in three mouse models of neurodegeneration: the APP-PS1 …
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Mouse models of osteoarthritis and joint injury
… complexity of the disease makes the use of human models impractical and complicated. Therefore, various animal models have been developed to study the progression of OA and possible therapeutic techniques. Of those models, mouse models play an integral part because of their cost-effectiveness, …
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CHARACTERIZATION OF IMMUNE RESPONSE IN EXPERIMENTAL MOUSE MODELS
… in healthy and pathologic experimental murine models, through immunohistochemical characterization of immune cell populations in healthy steady state, inflammatory and neoplastic settings. The following fields were investigated: Study I – Mononuclear phagocyte system cells in murine healthy …
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Factors Influencing Topotecan CNS Penetration in Mouse Models
… in determination of topotecan CNS penetration in mouse models by using cerebral microdialysis. Microdialysis sampling of drugs in ventricular cerebrospinal fluid (vCSF) provides insight into drug penetration into the brain across the blood CSF barrier (BCB); however, this method has been reported …
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Cellular Immunity in Mouse Models of Viral Encephalitis
… conducted in a conditional ablation transgenic mouse model that allowed for the selective depletion of these cells with diphtheria toxin (DT). Microglia isolated from infected brains rapidly upregulated expression of major histocompatibility complex (MHC) class I antigens, program death receptor …
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Development of inducible transgenic mouse models for melanoma
… of this project was to establish a transgenic mouse model able to investigate the molecular mechanism(s) of melanoma aetiology mediated by N-Ras and PTEN genes. To achieve this, an inducible gene switch approach was employed exploiting the Cre/loxP recombinase system. This approach has the …
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Characterisation of transgenic mouse models of Alzheimer's disease
A number of transgenic mouse models have been developed to study the molecular and pathological alterations associated with Alzheimer’s disease (AD). The 3xTg mouse is widely used as a research tool and carries mutations in the amyloid precursor protein (Swedish APP K670N/M671L), presenilin 1 …
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Immune cell alterations in mouse models of prostate cancer
… in immune status during tumour progression using mouse models of prostate cancer. Detailed analysis of the immunological status in a mouse prostate dysplasia model (12T-7slow) revealed that immune suppression accompanied tumour progression. We found that T cells isolated from tumour-bearing hosts …
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Exploring Risk Factors of Alzheimer’s Disease Using Mouse Models
<p>Mouse models of Alzheimer’s disease (AD) that accurately recapitulate pathology and molecular changes are crucial for understanding disease mechanisms and subsequent therapeutic development. We examined five commonly used mouse models of AD (5xFAD, J20, APPNL-F, APPNL-G-F, Tau P301S) and …
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CNS Penetration of Tyrosine Kinase Inhibitors in Mouse Models
… preventing erlotinib and OSI-420 penetration in mouse brain. Intracellular accumulation studies confirmed the role of BCRP in erlotinib and OSI-420 transport. We also characterized the role of solute carrier transporters in erlotinib and OSI-420 brain accumulation. Our data show that erlotinib …
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Gene therapy in mouse models of spinal muscular atrophy :
… Motor Neuron (SMN) protein. Here we utilize SMA mouse models to demonstrate that self-complementary Adeno-associated virus encoding SMN1 (scAAV-SMN) is a promising therapeutic for the treatment of SMA. We show that pre-symptomatic, ubiquitous restoration of SMN via scAAV is able to dramatically …
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The modulation of autoimmune disease progression in mouse models
… a better modulation of disease development using mouse models. These diseases have circulating autoantibodies that are mostly mutated with an IgG isotype, indicating B cells that are producing them have been through the process of affinity maturation. Activation-induced cytidine deaminase (AID) is …
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Identification and Characterisation of New Mouse Models for Hearing Loss
Mouse N-ethyl-N-Nitrosourea (ENU) mutagenesis programmes have been successfully employed for the identification of models of human disease, and allowed the discovery of novel gene associations. This thesis describes the characterization of two new ENU-induced mouse models of hearing loss, goya and …
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Cell-Type Specific Translational Profiling in Huntington's Disease Mouse Models
… and striatonigral MSNs in the R6-2 and YAC128 HD mouse models at pre- and post-symptomatic time points using the BACTRAP technique (Heiman et al, 2008). We re-characterized the behavioral phenotype of the HD model mice on the D1 and D2 TRAP backgrounds and found many changes in the translated mRNA …
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Study of anti-inflammatory functions of HDL in experimental mouse models
HDL has important immunomodulatory properties, including the attenuation of lipopolysaccharide (LPS)-induced inflammatory response. Τhe purpose of this study was to investigate the potential correlation between HDL shape and composition and its anti-inflammatory functions and properties in …
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Gain-of-Function Mouse Models to Investigate Biological Roles of Prmt6
<p><strong>Gain-of-function Mouse Models to Investigate Biological Roles of PRMT6</strong></p> <p>Alessandra Di Lorenzo, Ph.D. Candidate</p> <p>Mentor: Dr. Mark T. Bedford</p> <p>Protein Arginine Methyltransferase 6 (PRMT6) is the histone tail writer that methylates the H3R2 (arginine 2 of histone …
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Brain functional connectivity and its aberrations in mouse models of autism
… first describe the intrinsic organization of the mouse brain at the macroscale as seen through resting-state fMRI (rsfMRI). The analysis of a large rsfMRI dataset revealed the presence of six distinct functional modules related to known brainwide functional partitions, including a homologue of the …
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