Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 70 for “"Mouse liver"”.
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Integrative Multivariate Analysis of Mouse Liver Acini
Hepatocytes are the primary constituents of liver cells, performing numerous functions vital for sustaining life. The microenvironment of these cells is not homogeneous; specifically, two cell types known as periportal and pericentral hepatocytes in the liver are region-specific. This is due to the …
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Genetic Analysis of The Hippo Pathway In Mouse Liver
… Hippo pathway by putting floxed alleles into the mouse genome flanking the functional-domain-expressing exons in each component (<em>Mst1, Mst2, Sav1, Lats1</em> and <em>Lats2</em>). These mice were then crossed with different cre-mouse lines to generate conditional knockout mice. Results indicate …
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A novel pathway for VLDL assembly in the mouse liver
Es wird davon ausgegangen, dass LDL von der Leber und von peripheren Zellen endozytiert und vollständig abgebaut wird. Mit Hilfe primärer Maushepatozyten, durch Mausleberperfusion und durch intravenöse Injektion von LDL an Mäusen wird in der vorliegenden Dissertationsschrift gezeigt, dass als LDL …
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In Vivo Genome Editing: Proof of Concept in Neonatal and Adult Mouse Liver
… show great potential for therapeutic gene delivery for monogenic diseases, including hemophilia. Major limitations of this approach are the inability to persist in dividing cells and the restrictive packaging capacity of AAV. Gene targeting, the ability to make site-directed changes to the …
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Do Elevated Levels of Glutathione Decrease the Toxicity of Plasticizers in Mouse Liver Cells?
… study aims to investigate the response of two mouse hepatoma cell lines to the effects of DEHP and its bioactive metabolite mono (2-ethylhexyl) phthalate (MEHP). Cells were exposed to four concentrations (10, 50, 100, and 300 µM) of DEHP and MEHP, which are consistent with levels encountered in …
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Investigating the molecular biology of aging and extended longevity: Proteomic and genomic analysis of mouse liver
… bond formation. In these studies, young and aged mouse liver homogenates were separated into enriched sub-cellular fractions, and the ER/mitochondrial fraction was resolved by 2-dimensional gel electrophoresis and then assayed for oxidative damage as indicated by protein carbonylation. MALDI/TOF …
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Establishment of new human and mouse liver cancer models and their use to uncover the role of RNF43 and ZNRF3 in liver homeostasis and repair
Primary liver cancer (PLC) is the second most common cause of cancer death worldwide, preceded only by lung cancer. Current models for PLC either fail to fully recapitulate tumour histology and architecture or are expensive, time consuming and do not allow for personalised drug testing. During the …
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Quantitative pharmacoproteomics investigation of anti-cancer drugs in mouse. Development and optimisation of proteomics workflows for evaluating the effect of anti-cancer drugs on mouse liver
… is to apply comparative proteomics studies on livers from male and female mice xenograft models treated with major anti-cancer drugs (5-flourouracil, paclitaxel, cisplatin, and doxorubicin) and CYP inducer, TCPOBOP, to investigate their effect on protein expression profiles (proteome). Within …
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ΦΩΣΦΟΔΙΕΣΤΕΡΟΛΥΤΙΚΗ ΔΡΑΣΗ ΣΕ ΚΥΤΤΑΡΟΠΛΑΣΜΑ ΣΥΚΩΤΙΟΥ ΠΟΝΤΙΚΟΥ C3HB. ΚΑΘΑΡΙΣΜΟΣ ΚΑΙ ΜΕΛΕΤΗ ΙΔΙΟΤΗΤΩΝ ΤΕΣΣΑΡΩΝ ΕΝΖΥΜΩΝ
THE ACID RIBONUCLEOLYTIC ACTIVITY OF MOUSE LIVER CYTOPLASM IS DUE TO 2 RIBONUCLEASES. THEY ARE LOW MOLECULAR WEIGHT ENZYMES THAT RESIST ACID CONDITIONS BUT ARE DESTROYED AT 100 K FOR 10 MIN . THE ENZYMES SHOW DIFFERENT PRETENCES TOWARDS END-LABELLED NATURAL SUBSTRATES (55 RNA). RNASE I SHOWS THE …
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Some effects of thyroid hormones on renal and hepatic ultrastructure in the mouse
… ultratructure have been investigated in both mouse liver and kidney. The tissues were examined after various preparation procedures, and as well as subjective visual examination of infrastructure, attempts were made where possible to gain quantitative information of variations.
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Using affinity purification -- mass spectrometry to identify aryl hydrocarbon receptor nuclear translocator interacting proteins
… that interact with ARNT.</p> <p>We chose mouse liver as the protein source. We planned to isolate the ARNT interacting proteins from the mouse liver protein extract by using the TALON® resin </p> <p>column bounded with 6x HIS-ARNT. Two negative control experiments were done. The first one …
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Covalent Binding and other Mechanisms of Primaquine Toxicity
… dose-dependent covalent binding of primaquine to mouse liver microsomal protein was found in both in vitro and in vivo studies. The binding in vitro was linear during the first 90 minutes of incubation and dependent on the concentration of mouse liver microsomal protein. The in vitro covalent …
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Microarray Analysis Identifies Novel Cholesterol Regulated Genes, Including Pcsk9 Which Regulates LDL Receptor Function and LDL Cholesterol Levels
… regulatory element binding proteins (SREBPs) and liver X receptors (LXRs). This thesis describes the identification by microarray technology of novel genes in cholesterol metabolism and the characterization of two of these genes. Microarray analysis of the livers of mice fed a low versus high …
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Epigenomic and Transcriptional Regulation of Hepatic Metabolism by REV-ERB and Hdac3
… deacetylase 3 (HDAC3) is recruited to the mouse liver genome in a circadian manner. Histone acetylation is inversely related to HDAC3 binding, and this rhythm is lost when HDAC3 is absent. Diurnal recruitment of HDAC3 corresponds to the expression pattern of REV-ERBα, an important component …
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The Role of Small Peptides in Cancer Physiology and Chemotherapy
… metabolites, in targeting the drug melphalan to mouse Ehrlich ascites tumor cells. The dipeptide beta-alanyl-melphalan was synthesized and tested in vitro for toxicity towards mouse Ehrlich ascites tumor cells, mouse liver cells, and mouse 3T3 embryonic cells. The parent compound, melphalan, was …
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A Rhapsody on the Aryl Hydrocarbon Receptor: Molecular and Environmental Health Insights Through Novel and Canonical Signaling Pathways
… role of the AhR in cellular replication during liver regeneration. Based on our findings, we then set out to assess transcriptional targets of the AhR in the mouse liver following exposure to 2,3,7,8-tetrechlorodibenzo-p-dioxin. Finally, given the toxicities with which the AhR is associated, we …
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