Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Mouse Knockout"”.
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Investigation of Adiposity Phenotypes in AA Associated With GALNT10 & Related Pathway Genes
… quantitative trait loci (eQTL) data, and a mouse knockout model, in addition to furthering our knowledge of genes in the pathway in which GALNT10 acts. Previously, genome-wide association studies in African Americans (AA) have identified common variants upstream of GALNT10 locus for …
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Serum response factor-dependent regulation of smooth muscle gene transcription
… Using a combination of transgenic reporter mouse and knockout mouse models I demonstrated that a CArG element in intron 15 of the mylk1 gene is necessary for maximal transcription of smMLCK. SRF binding to this CArG element modulates the expression of smMLCK to control smooth muscle …
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Cold Shock Domain Proteins in Normal and Leukemic Hematopoiesis
… Ybx1 function in late-stage embryogenesis in mouse knockout models. Nevertheless, most studies that have sought to clarify the role of YBX1 in cancer have failed to consider a possible role for MSY4 complementation in cells where both genes are expressed. In mice deficient for either Ybx1 or …
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Characterization of the Functional Role of the Intracellular Cholesterol Transporter StARD4 in Knockout Mice, and Investigation of Epigenetic Modulation of ApoA-I Transcription
… regulated by SREBPs and we have chosen to make a mouse knockout model to characterize its role in-vivo. StARD4, expressed primarily in liver and macrophages, is a known intracellular cholesterol transporter previously shown to be down-regulated ~2 fold in liver, by high cholesterol feeding. It is …
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HIF-2: Standing Guard at the Crossroads of Stress and Aging
… studies from the Garcia laboratory using mouse knockout studies, we demonstrated the importance of HIF-2 alpha in the in vivo regulation of genes involved in the cellular response to hypoxic and oxidative stress. These genes include Erythropoietin (epo), vascular endothelial cell growth …
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Using human induced pluripotent stem cells to model cystinosis
… in the presentation of the disease in the mouse knockout. As such, there is no consensus on the pathways responsible for the cause of the disease. In order to develop a better human cell-based model of cystinosis, our lab has generated human pluripotent stem cells from a cystinosis patient …
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Targeted Disruption of the Deaf1 Gene in Mouse Brain and the Effects on Behavior and Gene Expression
… sex-specific depression. Standard (whole body) knockout of <italic>Deaf1</italic> has been reported to alter 5-hydroxytryptamine (serotonin) receptor 1A (<italic>Htr1a</italic>) levels in the frontal cortex and dorsal raphe nucleus. We hypothesized that mice with targeted deletion of …