Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Mouse Cortex"”.
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Modeling friction force avalanches in molybdenum disulfide and spiking neuronal avalanches in mouse cortex
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-12-04 without embargo terms
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The Molecular Correlates of Sleep and Sleep Deprivation in vivo and in vitro
… Chapter 3 outlines the transcriptome of mouse cortex collected over 54 hours from mice subjected to varied durations of sleep deprivation. The timecourse experimental design aids in the identification of genes that are induced during both spontaneous and enforced wakefulness, and …
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Transcription factor Pax6 protects mouse cortical cell fate specification
The mammalian cortex is composed of two main types of neuron. Principal cells (PCs) are glutamatergic and use glutamate as the main neurotransmitter. Interneurons are mostly GABAergic and use GABA as their main neurotransmitter. PCs are the output units of the cortex and comprise ~80-85% of the …
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Imaging Chloride Homeostasis in Neurons
… have been demonstrated in vivo in the mouse cortex, in real-time monitoring the dynamic changes of ions concentrations during epileptic-like discharges, and in glioblastoma primary cells, measuring osmotic swelling responses to various drugs treatment.
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Automated cell-targeted electrophysiology in vivo and non-invasive gamma frequency entrainment
… neurons of multiple types in the living mouse cortex, with yields comparable to skilled human experimenters. By facilitating targeted patch clamp recordings in vivo, our robot may enable scalable characterization of identified cell types in intact neural circuits. Activities of individual …
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Structural dynamics and synaptic development in the visual system
… a period of synaptogenesis in the developing mouse cortex. The second study extends these findings and examines the properties of dendritic spines during a period of heightened visual cortical plasticity and describes how manipulations of visual input alter these dendritic structures. The …
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Understanding the Conserved and Species-Specific Functions of FOXP2, a Gene Implicated in Speech and Language Development
… expression data from human, macaque, and mouse cortex in order to identify human specific, primate specific, and conserved subplate genes regulated by FOXP2. This study not only identified human specific targets in this expanded, transient region, but it may also inspire research of the …
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The Role of MeCP2 and FoxG1 in Embryonic Cortical Development: Implications for Autism Spectrum Disorders
… patterns of FOXG1 and MECP2 in the developing mouse cortex 2. Potential reciprocal regulation between these factors at the transcriptional level 3. The impact of FOXG1 and MECP2 deficiency on gene expression programs in neural progenitor cells and early differentiating neurons 4. Overlapping …
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Developmental myelination and myelin plasticity during spatial working memory task acquisition
… develops in a specific pattern over time in the mouse cortex, slowly progressing upward up from the deeper cortical layers to the surface of the brain. Furthermore, over the course of a lifespan myelin internodes lengths become more variable. This increased variability could potentially represent …
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The Effect of Early Dietary Intervention on Alzheimer's Disease-Related Pathology and Cognitive Function in Mice
… pathology and cognitive function in AD mouse models might be explained by experimental variations, including AD mouse model, sex of the animals, composition of the HFD, and timeline of HFD consumption. Our study examined the effect of varying the timeline of HFD or control diet (CON) …
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The role of ATM responding to DNA damage induced by Xrcc1 deficiency during oligodendrocyte genesis
… DNA strand breaks. Xrcc1nes-cre; Atm-/- mouse recapitulates the neurological phenotypes of A-T patients including cerebellar ataxia, cerebellar atrophy, defect of Purkinje cell and dysmyelination in the brain. In the case of dysmyelination, this is a subset of white matter disorders …
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Functional and ultrastructural investigation of mouse and human dendritic spines
… formation of nascent connections in the adult mouse cortex, and we developed a new method to apply these techniques to human neurons. In the first project presented in Chapter 2, we used super-resolution protein imaging and patch-clamp electrophysiology to identify filopodia as the structural …
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Neuroprotective effects of incretin mimetics upon chronic endoplasmic reticulum (ER) stress : implications for novel therapeutic pathways and opportunities in Alzheimer's disease
… of the dual incretin in the APPswe/PS1∆E9 mouse model for AD at the age of 10 months and compared them to Liraglutide and the glucosedependent insulinotropic peptide (GIP) mono-therapy. Once-a-day intraperitoneal administration of 25 nmol kg−1 of the dual incretin for two months halted the …
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Experience dependent coding of intonations by offsets in mouse auditory cortex
… Our work utilizes a natural paradigm in which mouse mothers learn the behavioral significance of pup ultrasonic vocalizations during maternal experience to study auditory cortical plasticity in a natural social context. Specifically, we aim to determine how mice learn to use acoustic features …