Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 60 for “"Motor deficits"”.
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The Effect of L-DOPA and Natural Products on Age-Related Motor Deficits and Dopaminergic Cell Survival
With age, there is a loss of motor coordination leading to an increase in falls. Currently, there are limited therapeutic regimens for age-related motor deficits. However, L-DOPA is used for motor dysfunction in Parkinson's disease (PD). Therefore, we investigated the effect of L-DOPA on motor …
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An Assessment of Deficits in Simple Discrimination Following Frontal Traumatic Brain Injury in Rats: The Relative Contribution of Motor Deficits, Motivation Deficits and Neuroprotective Drug Administration
… administering a neuroprotectant could alleviate deficits in discrimination. Long-Evans rats were trained on a simple visual discrimination task and a progressive ratio schedule of reinforcement (PR). After assessing their baseline discrimination performance, motor ability and PR performance, they …
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Neuromuscular Deficits Associated With KMT5B Haploinsufficiency in Mice
… with additional symptoms such as seizures and motor deficits. These motor deficits are characterized as hypotonia and motor delay. Kmt5b already has a known role in skeletal muscle, maintaining skeletal muscle stem cell quiescence. However, this was found only in an adult, repeated injury …
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Study of biological phenomena implicated in neuromuscular ageing
… made the local consequences of NMJ detectable as motor deficits by using disparate exogenous and endogenous models to induce synaptic inactivity in developing Xenopus laevis tadpoles. We resolved whether: (1) synaptic inactivity increases mitochondrial ROS; (2) chemically heterogeneous …
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Motor Network Organization in Frontal Lobe Epilepsy
… disorder that commonly coincides with functional motor deficits. While the source of these deficits is unknown, it is postulated that repeated seizure activity within the frontal lobe might impact the proximate motor network. To examine this hypothesis, motor networks were compared between …
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Neurocognitive outcome of HIV-infected children on antiretroviral therapy at Red Cross Children's Hospital
… may arrest or even reverse neurocognitive and motor deficits associated with HIV infection.
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Effects of dopamine depletion in the nucleus accumbens on lateral hypothalamic self-stimulation in the rat
… complicated by across-subject averaging and by motor deficits, which are thought to be due to destruction of dopaminergic projections to the dorsal striatum. In contrast, the changes in reward have been linked to changes in the dopaminergic input to the nucleus accumbens (NAcc). We reexamined …
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Development of mouse models of hydrogen sulfide-induced neurotoxicity for the evaluation of neuroprotective strategies
… seizures and knockdown in the mice, and induced motor deficits, neurochemical alterations, neuroinflammation, oxidative stress and neuropathology. Our data demonstrated that Cobinamide dose and time dependently reduced the behavioral deficits, neuroinflammation, neurochemical changes, oxidative …
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Exploring Immersive Virtual Reality as a screening and assessment tool for upper limb function and coordination
… effective medium by which to measure upper limb motor performance. However, work on this topic is limited, and studies often fail to consider the arduous development process, or the technical viability of these tools in practical settings. This thesis documents the development and testing of two …
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Synthetic and Natural Environmental Compounds as Potential Facilitators of Mptp-Induced Parkinsonism
… Lewy body disorder characterized by severe motor deficits, followed by cognitive dysfunction with progression of the disease. Environmental exposure has been suggested as a possible contributor to the development of PD and this view is linked to the discovery of the nigrostriatal neurotoxin …
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Temporal and spatial muscle synergy features and its neural origins during sit-to-stand and stand-to-sit tasks
… disruptions and present a correlation with motor deficits. Therefore, this review aims to understand the importance of these two transitional motions and muscle synergy extensively to help develop targeted interventions for healthy and clinical populations.
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THE EFFECTS OF PARKINSON’S DISEASE AND ASSOCIATED TREATMENTS ON SACCADIC EYE MOVEMENTS
… disease in order to bypass the distal limb motor deficits seen with disease progression. This study aimed to use eye movements to correlate disease severity with performance on a battery of cognitive tasks, and ultimately elucidate some of the mechanisms behind the disease. Our initial …
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Relationship between language impairment and sensory processing disorder
… SLI, sensory sensitivity, adaptive development, motor deficits, autism spectrum disorders, SPD
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Concussion Recovery and Skilled Performance in Working-Aged Adults: Sex Differences in the Neural Correlates of Persisting Symptoms After Concussion
Cognitive-motor integration (CMI) refers to the ability to follow rules that guide perception and action. Following a concussion, CMI neural networks are often disrupted, impairing complex movement. We previously identified links between white matter integrity and visuomotor performance in …
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Attention, processing speed and executive functions in children with obstructive and communicating hydrocephalus
… impairment such as gross and fine motor deficits, spatial perceptual problems, and slowed processing speed. To date there is a paucity of research that compares the neuropsychological functioning of children with obstructive and communicating H C . This study aimed to compare …
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Variability in bimanual coordination across the continuum of handedness.
… communication to produce coordinated movements. Motor deficits affect a variety of clinical populations, yet a complete understanding of bimanual coordination has yet to be achieved. Previous research suggests performance variability depends on the phase demands of the coordinated task and …
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Voxel-Based Lesion Symptom Mapping as a Predictor of Motor Impairment after Stroke
… analysis was utilized to predict degree of motor impairment based on lesion location. Magnetic Resonance Imaging (MRI) was used to collect T1 weighted structural images of lesions in 11 participants who suffered primarily left hemisphere damage due to stroke. Assessments from the Lower …
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The Effect of Grapes in Mice with Alzheimer's Disease and Brain Injury
… disorder resulting in cognitive and memory deficits and deposits of amyloid beta (Aβ) in the cortex and hippocampus are thought to be significant contributors to the disease process. Increasing evidence suggests that foods rich in polyphenols, such as pomegranates and grapes, may have …
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Impact of Neurodevelopmental Disorder-Associated Clinical Variants on the Catalytic Activity of KMT5B
… like developmental delay (DD), intellectual deficits (ID), autism spectrum disorder (ASD), seizures, and motor deficits. However, the impact of these variants on enzyme activity is unknown. In this work, we provide qualitative and quantitative evidence showing the differential impacts of four …
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IN VIVO DETECTION OF DOPAMINERGIC DYSFUNCTION IN A RAT MODEL OF MODERATE INTRAUTERINE ASPHYXIA
… to death, cerebral palsy, or major sensory/motor deficits by one year of age. The remaining cases are clinically defined as either `mild' or 'moderate' and have a more uncertain outcome. Though mild to moderate HIE is typically survivable, recent epidemiological evidence shows higher rates …
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