Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Motor Neurone Disease"”.
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Engaging with Motor Neurone Disease
… research engagements in the context of Motor Neurone Disease (MND). To do this, I use interviews and observations to explore how experiences are shaped and situated. By connecting geography, science studies, disability and applied health research, the project brings together debates …
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Outcomes of Enteral Feeding in Motor Neurone Disease
Motor Neurone Disease (MND) is a fatal neurodegenerative disease of unknown aetiology characterised by the degeneration of motor neurones leading to progressive wasting and weakness of the bulbar, limb and respiratory muscles. Symptomatic treatment remains the cornerstone of management. …
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Understanding mechanisms related to psychosis in Motor Neurone Disease
… is a challenging feature of the syndromes of motor neurone disease (MND), frontotemporal dementia (FTD) and their overlap (FTD-MND). Clinically evident psychosis is not common, except in those with C9orf72+ expansions. However, subthreshold psychosis or pre-psychosis processes are common and …
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Role of eEF1A-2 in the pathogenesis of Motor Neurone Disease
Motor neuron disease, or amyotrophic lateral sclerosis (ALS), is a disorder characterised by progressive weakness and atrophy of skeletal muscles, caused by the selective loss of motor neurons. It occurs in both familial and sporadic forms. Although the genetic basis of the disease in a minority of …
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The involvement of free radicals in the casual mechanism of Motor Neurone Disease
… cell viability. The progressive loss of motor neurones associated with motor neurone disease (MND) may be due to acute or chronic free radical damage causing irreversible cell lesions. Perturbation in the mechanisms involved in the cell's protection against the deleterious effects of free …
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The personal experience of carers of individuals with Motor Neurone Disease (MND) and their experiences of services
… of individuals with a partners diagnosed with Motor Neurone Disease (MND). Lastly, a public domain provides a summary of the empirical paper.
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A review of cases of motor neurone disease seen at Groote Schuur Hospital from 2005 to 2010
Motor neurone disease (MND) is a rare progressive neurodegenerative disorder in which selective degeneration of the motor neurones of the brain and spinal cord occurs. Progressive weakness of limb, bulbar and respiratory muscles eventually results in death. Most descriptive and epidemiological …
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Population-based genotype-phenotype correlation to stratify incident cases of motor neurone disease in Scotland from 2015-2017
BACKGROUND: Motor neurone disease (MND) refers to a spectrum of rapidly progressive neurodegenerative diseases for which there remains no cure. A recognised and crucial barrier to more accurate diagnosis, prognosis and treatment relates to phenotypic heterogeneity. Recent discoveries in the genetic …
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Development and analysis of hierarchical feedforward neural network systems for classification of motor neurone disease based on magnetic resonance spectra
… changes in brain metabolites are associated with Motor Neurone Disease (MND). Magnetic Resonance Spectroscopy (MRS) has been performed on the brains of MND patients and control volunteers to acquire signals which contain information about brain metabolites from within the motor cortex area. …
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A qualitative study into the communication surrounding the initiation and withdrawal of non-invasive ventilation (NIV) in people with Motor Neurone Disease
Introduction Motor neurone disease (MND) is a degenerative disease that adversely affects the nervous system and muscular control. Eventually respiratory muscles weaken, causing breathing, communication and swallowing difficulties, and ultimately, respiratory failure and death. Improved quality of …
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Endosomal Sorting Complex Required for Transport (ESCRT): Investigation of the expression and functional roles in neurodegenerative diseases
… have been linked to various neurodegenerative diseases such as Alzheimer's disease (AD), Huntington's disease, Parkinson's and Motor Neurone disease (MND). This study investigated the expression of ESCRT proteins in age matched nonneurodegenerative brains, AD brains, MND brains and spinal cord. …
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A qualitative exploration of the movement disorder experience
… the diagnostic experience of either Parkinson’s disease, multiple sclerosis, motor neurone disease or Huntington’s disease from the individual’s perspective. Three major themes emerged: “A bomb that could not be absorbed”: The emotional experience of receiving a diagnosis; “You’ve got what your …
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Developing volunteering as an intervention for social isolation in those with long-term neurological conditions
… and progressive conditions, such as Parkinson’s disease, motor neurone disease or ataxia. The Medical Research Council (MRC) framework was used as a guideline to inform the development of a complex intervention. Specifically, this thesis contained 3 studies: Study 1: a scoping review mapped the …
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Perceptions of cause and control in people with Parkinson's disease
… illness beliefs in people with Parkinson’s disease (PD), namely perceptions of cause and perceptions of control. The first section presents a narrative synthesis of the quantitative research on the demographic, clinical and psychological correlates of control in PD and two other chronic …
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Investigating the effect of amyotrophic lateral sclerosis-associated mutant vesicle-associated membrane protein B on axonal transport
… sclerosis (ALS) is a fatal neurodegenrative disease characterised by selective degeneration and death of motor neurons. The architecture of neurons makes them dependent upon the proper transport of protein and organelle cargoes, especially through axons (axonal transport). Indeed, disruption …
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Couples living in twilight: A Heideggerian hermeneutic study of sexuality and intimacy in lifelimiting illness
… of patients who had either terminal cancer or motor neurone disease. Consistent with Heidegger’s (1962) hermeneutic circle of interpretation, I used an adaptation of Diekelmann’s (1992) iterative approach to analyse the data. This study brings new understanding of the human condition. When …
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Studies on Bioactive Lipid Mediators Involved in Brain Function and Neurodegenerative Disorders. The effect of ¿-3PUFA supplementation and lithium treatment on rat brain sphingomyelin species and endocannabinoids formation; changes in oxysterol profiles in blood of ALS patients and animal models of ALS.
… markers of this action in relation to age and disease stages. These analytes were extracted from tissue samples and analysed with GC, LC/ESI-MS/MS and GC-MS. It was found that aged rats exhibited a significant increase in brain AA and decrease in ¿n-3 and ¿n-6 PUFAs when compared to adult …