Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Motile cilia"”.
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Understanding the Collective Dynamics of Motile Cilia in Human Airways
… organisms rely on the coordinated beating of motile cilia for a multitude of fundamental reasons. In smaller organisms, such as Paramecium and the single cell alga Chlamydomonas reinhardtii, it is a matter of propulsion, to swim towards a higher concentration of nutrients or away from damaging …
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The role of hydrodynamic forces in synchronisation and alignment of mammalian motile cilia
Fluid flow generated by a ciliated epithelium is a fascinating evidence of collective behaviour in nature. In many organs and eukaryotic organisms, thousands of microscale whip-like structures called 'motile cilia' beat aligned at the same frequency and in a coordinated fashion. This dynamics, …
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Investigating the role of R2TP-like co-chaperone complexes during axonemal dynein assembly
Motile cilia are specialised cell-types which in humans have important roles in the linings of the airways, the reproductive system and the brain. The movement, required for this type of cilia to function, is facilitated by structures called axonemal dynein motor complexes. These are large, …
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Characterization of the Placenta-Specific 8.1 Gene Function during Zebrafish Embryogenesis
… phenocopied the class of mutants with defective cilia. Consistently, the motile cilia morphology and motility were impaired in plac8.1 morphants. Moreover, in immunoprecipitation experiments, Plac8.1 bound Cops4, a component involved in ubiquitination regulation. Also Plac8.1 and Cops4 cooperated …
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Identification of a Novel ERK 1/2-Interacting A-Kinase Anchoring Protein
… identified radial spoke structural components of motile cilia and is required for axonemal sliding and flagellar motility. The mammalian orthologs for this and other radial spoke proteins, however, remain to be identified and fully characterized. Mammalian RSP3 was found to interact with ERK2 …
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SPAG16 is a Bifunctional Gene Regulating Male Fertility
… provides the cytoskeletal core of all eukaryotic motile cilia and flagella. In Chlamydomonas, the Pf20 gene encodes a single protein present in the central pair of the axoneme. Loss of Pf20 prevents central pair assembly and results in flagellar paralysis. The murine Spag16 gene encodes two …
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Investigating the Biological Mechanisms Underlying Axis Morphogenesis Using a Novel Zebrafish Model of Idiopathic-like Scoliosis
… Although our lab has previously implicated motile cilia dysfunction, cerebrospinal fluid (CSF) flow defects and neuroinflammation in zebrafish models of AIS, loss of cilia motility in humans does not fully associate with scoliosis, suggesting other pathogenic mechanisms remain to be …
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Exploring Ciliary Dynamics: Assessing Motility and Induced Velocity in Human Airway Cell Cultures
… to the terminal bronchioles is lined by a mucociliated epithelium. Here, cilia underpin an essential defence mechanism known as MCC. This process clears inhaled pathogens and contaminants from the airways and exhibits various degrees of complexity. Differently from the case of microorganisms, …
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Towards structural characterisation of ciliary rootlets, ciliary caps and intraflagellar transport
Cilia elongation and homeostasis require the transport of building blocks and signalling molecules between the ciliary base and tip through a process called intraflagellar transport (IFT). IFT is driven by multiple copies of the ciliary motor proteins kinesin-2 and dynein-2 attached to train-like …
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Primary Ciliary Dyskinesia: An Epidemiological Exploration. Furthering our understanding of the burden of disease in PCD
Primary ciliary dyskinesia (PCD) is an underrecognized multisystem genetic disorder that is characterized by dysfunctional motile cilia and abnormal mucociliary clearance. In recent years, there have been significant advancements in the understanding of PCD including, but are not limited to, …
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Mutation of Polaris, an Intraflagellar Transport Protein, Shortens Neuronal Cilia
Primary cilia are non-motile organelles having 9+0 microtubules that project from the basal body of the cell. While the main purpose of motile cilia in mammalian cells is to move fluid or mucus over the cell surface, the purpose of primary cilia has remained elusive for the most part. Primary cilia …
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3D Nanoscale Architecture and Physiology of the Human Airway Epithelium
… of airway basal stem cells into multiciliated cells within the human respiratory epithelium – a tissue barrier crucial for protection against bacteria, viruses, and particulate matter. In this thesis, I present the first isotropic three-dimensional map of the human airway epithelium at …
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Controlling the collective dynamics in systems of active oscillators through geometry and hydrodynamic entrainment
… oscillators, a highly simplified model for motile cilia that approximates each cilium by a rigid sphere that is driven by a geometrically updated force. The simplicity of the model lends itself to generic results that could be observed in many systems with hydrodynamic coupling. This thesis …