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Showing 1 to 4 of 4 for “"Mother Machine"”.
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Approaches for Microfluidics-Enabled, Bacterial, Single-Cell Synthetic Biology
… specifically a microfluidics geometry called "Mother Machine". A Mother Machine microfluidic device (MFD) consists of a simple feeding lane through which cell medium flows, with perpendicularly connected cell trapping chambers, called trenches. This has previously been used to study wild-type …
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Investigation of Bacillus subtilis Sigma Factor Dynamics Using Improved Single Cell Tools
… a single cell microfluidic device based on the ”mother machine” design, for the rod-shaped cyanobacterium, \textit{S. elongatus}, which forces the cells to grow in a straight line. Growing this organism in a traditional mother machine device has, so far, proved challenging. To adapt the mother …
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Smart microscopy methods for quantitative microbiology
… factors, and deep learning techniques. The mother machine microfluidic device emerges as a robust tool for quantitative microbiology, and our ability to simulate images of it guides its design. Deep learning segmentation models trained on synthetic data demonstrated reduced bias, greater …
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On the coupling of noisy processes in biology to produce functional phenotypic variability
Noise is ubiquitous in biology. Recent studies have demonstrated that both gene expression and physiological processes, such as growth, can be noisy. The cell-to-cell variation resulting from this stochasticity has been implicated in survival strategies for bacterial populations. However, it …