Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 61 for “"Morris water maze"”.
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A Behavioural, Molecular and Lesion Examination of Hippocampal Contributions to Morris Water Maze Acquisition
The Morris water maze (MWM) is a widely known, simple and effective task in the examination of spatial learning and memory. Successful acquisition of the task is thought to rely on retained representations of allocentric spatial relations, whereby animals learn to associate the location of a hidden …
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Gender Differences in Working Memory in Humans Tested on a Virtual Morris Water Maze.
<p>A computerized virtual version of the Morris water maze (vMWM) was used to assess human gender differences in spatial working memory. In Experiment 1, the release point and platform location was changed on every other trial for 20 trials. Men had significantly reduced acquisition latencies and …
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Age sensitivity of the Barnes Maze and the Morris Water Maze: Associations with cerebellar cortical Purkinje neurons
… neurobiological substrates as assessed by the Morris water maze (MWM) and the Barnes maze. The MWM is one of the most widely used tests of spatial memory and numerous studies suggest that spatial memory abilities decline with age. To contrast, very few studies exist comparing different ages of …
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A Multi-Region Analysis of the Acquisition, Consolidation and Retention of Spatial Memory in the Morris Water Maze using Immediate Early Gene Imaging
The Morris water maze has been extensively used in the study of spatial learning and memory, and a number of hippocampal, parahippocampal and neocortical brain regions have been identified as necessary for successful performance in this task. Immediate Early Genes (IEGs) have been implicated in …
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Efeito da administração crônica pós-natal dos ácidos propiônico e metilmalônico sobre o comportamento de ratos no labirinto aquático de Morris (Water Maze) e sobre alguns parâmetros bioquímicos de estresse oxidativo em hipocampo
… tratamento nas tarefas do labirinto aquático de Morris e no campo aberto. Os parâmetros bioquímicos avaliados foram o potencial antioxidante total do tecido (TRAP) e a atividade das enzimas catalase, superóxido dismutase e glutationa redutase. Todos as análises bioquímicas foram realizadas em …
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An Analysis Of Virtual Place Learning/navigation In Children And Young Adults Prenatally Exposed To Alcohol
… alcohol exposure impairs performance on the Morris water maze. This task requires the rodent to use distal room cues to locate a hidden platform in a pool of opaque water. Successful performance on this task is dependent upon hippocampal function. Rodents prenatally exposed to alcohol are …
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Mixed Dementia Induced by Right Common Carotid Artery Occlusion in an Alzheimer Mouse Model
… common carotid artery occlusion (rCCAO). The Morris water maze and object recognition tests were performed 6-8 weeks after the operation; the mice were then sacrificed. We evaluated cell death by histological studies and quantified the amount of amyloid plaques. An escape performance in the …
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An Examination of the Influence of Landmarks in Human Spatial Navigation Using a Virtual Water Maze
… navigation excelled with the invention of the Morris Water Maze (Morris, 1984). In this task animals are required to find a platform, hidden somewhere in a large circular pool of water (below surface level). As animals cannot see the goal directly, they must use various cues in the environment …
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Confidence Intervals for the Difference and Ratio of Two Means from Independent Beta Distribution
… will be applied to real biological data from a Morris Water Maze experiment, with recommendations for best practices.</p>
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The role of the CB1 receptor in learning, memory and anxiety-like behaviors
… observed between CB1+/+ and CB1-/- mice in a Morris Water Maze acquisition task. Furthermore, CB1-/- mice did not display deficits in extinction during reversal learning. In the Light-Dark Box and Suok tasks, the CB1-/- mice demonstrated greater anxiety-like behaviors relative the CB1+/+ mice. …
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The role of the CB1 receptor in learning, memory and anxiety-like behaviors
… observed between CB1+/+ and CB1-/- mice in a Morris Water Maze acquisition task. Furthermore, CB1-/- mice did not display deficits in extinction during reversal learning. In the Light-Dark Box and Suok tasks, the CB1-/- mice demonstrated greater anxiety-like behaviors relative the CB1+/+ mice. …
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Transcranial Administration of Nano Pulse Laser Therapy for Blast Induced Neurotrauma
… using Beam Balance, Beam Walk, Neuroscore, and Morris Water Maze tests. After behavioral tests the animals were sacrificed for histology. In our second aim, male adult Sprague Dawley rats were given repeated blast injuries 48 hours apart. Within the injuries there were given NPLT pre-treatment, …
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Molecular therapy for mucopolysaccharidosis Type I
… prevention of a neurocognitive deficit in a Morris water maze test (Chapter 3). Infusion of the same vector into adult MPS I animals resulted in low levels of IDUA expression and partial reduction of storage material in the brain consistent with partial improvement in the Morris water maze …
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The Effect and Chronic Acute Pre-Treatment with Methylphenidate on Recovery of Cognitive Function Following Experimental Traumatic Brain Injury In Rats
… rats were assessed on post-injury using the Morris Water Maze. There was no effect of chronic MPH treatment on cognitive outcome following TBI. In contrast, acute MPH pre-treatment improved cognitive outcome as measured by the MWM. The MPH + injury group reached sham-injury levels on days 4 …
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A new class of neural architectures to model episodic memory : computational studies of distal reward learning
… This simulated environment realizes the Morris Water Maze task, a well established biological experimental test of distal reward learning. The embodied neural architecture is treated as a virtual rat and the environment it acts in as a virtual water tank. Performance levels of the neural …
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Learning and cemory in the cav1.2 knockout mouse
… for spatial learning and memory, a series of Morris water maze experiments were performed. Knockout mice showed no deficits in short-term (24-hr) memory trials; however, on a 30-day memory probe, knockout mice performed significantly more poorly than their littermate controls. These results …
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Effects of long-term hormone treatment on cognitive behavior and the structure of the medial prefrontal cortex during aging in female rats
… Estrogen was administered in the drinking water. Progesterone and MPA were administered with subcutaneous pellets. Following five months of hormone replacement, animals were tested on a delayed alternation task in the T-maze. Two weeks after completing the T-maze animals were tested in the …
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Efekt konzumace jednoduchých cukrů na kognitivní funkce potkaních samic
… female rats with 10% w/v glucose in drinking water or with isocaloric fructose solution in a long-term study (7 months), simulating the chronic consumption of sugars in humans. Plasma parameters and expression of proteins, involved in metabolic pathways, were determined in the frontal cortex. …
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An Assessment of Deficits in Simple Discrimination Following Frontal Traumatic Brain Injury in Rats: The Relative Contribution of Motor Deficits, Motivation Deficits and Neuroprotective Drug Administration
… usually a measure of spatial learning (e.g. Morris water maze). In other fields, alternative measures have been utilized for many years, including non-spatial discriminations. The primary goal of this study was to evaluate the use of a visual discrimination in a model of frontal TBI and …
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Accumulation Of Subcortical Iron As A Modifier Of Volumetric And Cognitive Decline In Healthy Aging: Two Longitudinal Studies
… directly with lesser improvement in virtual Morris water maze navigation, and indirectly via shrinkage with lesser improvement in verbal working memory. This study present the first longitudinal evidence in support of iron as a biomarker of age-related decline in regional volume and …
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