Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Morphogen signaling"”.
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Developing a stem-cell system of embryonic development organised by a morphogen signaling centre
… endoderm, and ectoderm are specified. Bone morphogenetic protein 4 (BMP4), secreted from the extraembryonic ectoderm is required for gastrulation to start whereby it activates downstream signaling molecules wingless inhibitor 3 (WNT3) and Nodal in a concentration dependent manner to specify …
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The glypican Dally binds to Lipophorin particles and increases Hedgehog signaling efficiency
… Lipoprotein particles bear lipid-linked morphogens on their surface and are required for long-range signaling activity of Wingless and Hedgehog. They also bind a wide variety of gpi-linked proteins. Whether any of these proteins affect morphogen signaling is unknown. Here, I show that the …
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NOGGIN Transport in a Model Human Epiblast
… In this work, I interrogate the interplay of the morphogen/inhibitor pair BMP4/NOGGIN within our model of the polarized human embryonic disc. Here, I report the surprising discovery that in human epiblasts, NOGGIN and BMP4 were selectively secreted into opposite sides of the polarized epithelium, …
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QUANTITATIVE MODELING OF SCALING OF PATTERNS AND RECEPTOR SIGNALING IN MORPHOGENESIS
… appropriate proportions and positions. The key signaling factors that guide a number of those processes are known as morphogens. Developing cells sense their respective positional information from a graded morphogen profile, and differentiate into patterns. Remarkably, patterns are highly robust …