Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Mononuclear phagocytes"”.
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Investigating the spatiotemporal dynamics of mononuclear phagocytes in solid tumours.
Mononuclear phagocytes (MNP), consisting of monocytes, macrophages and dendritic cells (DC), are major cell types of the innate immune system and their activation is required for an effective immune response, including the anti-cancer response. Tumour-associated macrophages (TAM) are a universal …
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Investigating the role of kidney mononuclear phagocytes in immune complex-induced inflammation.
Resident mononuclear phagocytes (MNPs) play key roles in tissue homeostasis, defence against infection and repair. Although MNPs have been studied for more than 130 years, there have been significant advances in our understanding of their role, origin, maintenance and interactions in recent years, …
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Investigation of the synovial tissue-homing mechanisms of circulating mononuclear phagocytes in treatment-naïve psoriatic arthritis.
… this infiltration are poorly understood. Mononuclear phagocytes (MPs) are abnormal in PsA, involved in neovascularisation, and the production/development of key cytokines and adaptive effectors. I aimed to identify the key interactions that drive MPs migration to joint tissue in active …
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The Balance of Interferon-γ and Interleukin-10 during Influenza A Virus Infection Complicated by Methicillin-Resistant Staphylococcus aureus Superinfection
… that IFN-γ receptor (IFN-γR) signaling in mononuclear phagocytes induces tumor necrosis factor (TNF)-α hyperproduction and lethal inflammatory lung damage, with no detectable benefit to viral or bacterial clearance. In contrast, we show that interleukin (IL)-10 is crucial to counteract the …
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Age-Dependent Determinants of Blood-Derived Monocytes Influence Neuroinflammatory Milieu at the TBI Injury Site
… and morphology of BDMs and resident mononuclear phagocytes during the acute phase of injury. We also looked at the population and polarization of resident mononuclear phagocytes during the chronic phase of TBI. We found an overall reduction in tissue damage in juvenile injected mice, …
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Binding of Mycobacterium tuberculosis to complement receptor type 3 expressed in mammalian cells : dependence on serum opsonins
Nonopsonic invasion of mononuclear phagocytes by Mycobacterium tuberculosis (M. tb.) is likely important in the establishment of a primary infection in the lung. M. tb. binds to a variety of phagocyte receptors, of which the mannose receptor and the complement receptor type 3 (CR3) may support …
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Ehrlichia chaffeensis TRP47 enters the nucleus via a MYND-binding domain-dependent mechanism and predominantly binds enhancers of host genes associated with signal transduction, cytoskeletal organization, and immune response
… bacterium that establishes infection in mononuclear phagocytes through largely undefined reprogramming strategies including modulation of host gene transcription. In this study, we demonstrate that the E. chaffeensis effector TRP47 enters the host cell nucleus and binds regulatory regions …
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Host-Dependent Expression, Transcriptional Regulation and Protection of Ehrlichia chaffeensis Tandem Repeat Proteins
… tick, Amblyomma americanum, and replicates in mononuclear phagocytes in mammalian hosts. The major immunoreactive proteins of E. chaffeensis include a group of tandem repeat proteins (TRPs) that are involved in various molecular strategies to reprogram the host cell during infection. The …
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ΡΙΤΟΔΡΙΝΗ ΚΑΙ ΕΝΔΟΚΥΤΤΩΣΗ (ΠΕΙΡΑΜΑΤΙΚΗ ΕΡΓΑΣΙΑ IN VIVO)
… OF RITODRINE ON THE PHAGOCYTIC ACTIVITY OF THE MONONUCLEAR PHAGOCYTES (M.P.S.) WAS STUDIED IN VIVO. THE CLEARANCE OF A CERTAIN QUANTITY OF CARBONPARTICLES (250A) FROM THE CIRCULATION WAS TAKEN AS AN INDICATOR OF THE PHAGOCYTIC ACTIVITY OF MPS ACCORDING TO THE METHOD PROPOSED BY HALPERN AND HIS …
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The ontogeny and function of intestinal dendritic cells
… studies had identified a major subset of CX3CR1+ mononuclear phagocytes which, by virtue of their capacity to sample antigen from the intestinal lumen, were thought to play key roles in the initiation of intestinal adaptive immune responses. In paper I, we assess the relationship between CD103+ …
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TRP75-Mediated STAT3 Activation Promotes Anti-Apoptotic Signaling and Ehrlichia chaffeensis Infection
… intracellular bacterium that manipulates mononuclear phagocytes by hijacking host cell signaling pathways to promote infection. In part, E. chaffeensis accomplishes host cell manipulation through the actions of secreted effector proteins, including the tandem repeat proteins (TRPs). The …
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Ehrlichia chaffeensis mediates Hedgehog and Hippo signaling to activate an anti-apoptotic cellular program
… underdiagnosis. Ehrlichia chaffeensis hijacks mononuclear phagocytes to escape host defenses through mechanisms executed by tandem repeat protein (TRP) effectors secreted by the type 1 secretion system. In the past decade, tandem repeat protein TRP120 has emerged as a model moonlighting …
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Identification and characterisation of Group 3 Innate Lymphoid Cells in the renal tract
… components of effective defence: the epithelium, mononuclear phagocytes (MNPs) and ILC3s. Key findings and conclusions Numbers of ILC3s and MNPs in the renal tract increased during UTI, as did their key products, interleukin 17 (IL-17a), IL-22 and granulocyte macrophage – colony stimulating factor …
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Mechanical loading and cartilage physiology
… paracrine loop between articular cartilage and mononuclear phagocytes. In vitro, chondroprotective and antiinflammatory actions of chondroitin sulphate, glucosamine sulphate, REV 5901 and Tamoxifen were associated with a reduction in pre-impact cell volume (average of 31.91±4.19 %) and increased …
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Experimental Models of Mycobacterial Replication and Killing in Macrophages
<p>This thesis investigates how human mononuclear phagocytes regulate the growth of mycobacteria. Previous studies carried out in our laboratory suggested that cell turnover [apoptosis and necrosis] within a granuloma may contribute to the control of mycobacterial infection. The experiments …
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The macrophage activating properties of growth hormone in vitro and in vivo: Comparison to interferon-gamma (IF N-gamma)
… GH augments the production of O$\sb2\sp-$ by mononuclear phagocytes in vitro and in vivo. When either native or recombinant GH were administered to hypophysectomized rats in vivo, activation of peritoneal M$\Phi$, as measured by O$\sb2\sp-$ release, was equivalent to that of M$\Phi$ from rats …
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Differential Stimulation of Monocytes to Secrete Secretory Leukocyte Protease Inhibitor by Lipopolysaccharide of Periodontal Pathogens
… to remain "stealthy" and avoid killing by the mononuclear phagocyte cells. Secretory Leukocyte Protease Inhibitor (SLPI) is a single-chain serine protease inhibitor secreted from secretary and inflammatory cells that protects tissue from damage caused by the inflammatory response. The present …
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Ehrlichia chaffeensis Activates Notch Signaling Through SLiM Mimicry to Inhibit Apoptosis
… tick-borne zoonosis. E. chaffeensis infects mononuclear phagocytes and has evolved molecular strategies to reprogram the host cell involving secreted effectors that interact directly with the host cell targets. Recently, we have shown E. chaffeensis evasion of innate defenses of the …
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Investigation of novel therapeutic strategies in B cell and antibody mediated disease
… Immune complexed antigen can activate mononuclear phagocytes (MNP), comprising macrophages and dendritic cells (DCs), via ligation of Fc gamma receptors (FcγR), that bind the Fc region of IgG. FcγR-dependent MNP activation results in profound changes in gene expression that mediate …