Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Mononuclear Phagocyte System"”.
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CHARACTERIZATION OF IMMUNE RESPONSE IN EXPERIMENTAL MOUSE MODELS
… PhD research project aimed to investigate immune system functions in healthy and pathologic experimental murine models, through immunohistochemical characterization of immune cell populations in healthy steady state, inflammatory and neoplastic settings. The following fields were investigated: …
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Oral uptake and distribution of microspheres
… to accumulate in greatest numbers within the Mononuclear phagocyte system tissues after gavage. Again translocation was rapid. The ability of test particles to leave the intestinal lumen and access systemic compartments was found to be highly dependent on their size and hydrophobicity, …
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The production and gene polymorphisms of tumor necrosis factor-alpha in patients with tuberculosis in the Vhembe District, Limpopo Province
… stimulate the production of cytokines via the mononuclear phagocyte system. Although mutations in immune-related genes may directly impact a host’s ability to control the infection when exposed to M.tb, the pro-inflammatory cytokine Tumor Necrosis Factor- α is crucial in host defence against TB …
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The Development and Characterisation of a Peptide Delivery Platform to Interrogate the Anticancer Effects of Bisphosphonates
The RALA peptide delivery system complexes anionic compounds through electrostatic interactions, to form a nanoparticle with the physiochemical characteristics to cross cellular membranes and escape endosomes; thereby releasing the cargo intracellularly to exert the optimal therapeutic effect. …
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Deficiência de arginina-vasopressina (diabetes insipidus central) como primeira manifestação de histiocitose de células de Langerhans: relato de caso
… (LCH) is a rare clonal neoplasm of the mononuclear phagocyte system characterized by proliferation of CD1a⁺/Langerin⁺ myeloid dendritic cells and activating mutations in the MAPK/ERK pathway (such as BRAF V600E and MAP2K1). Involvement of the hypothalamic–pituitary axis occurs in up to …
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Towards Understanding Nanoparticle Uptake by the Liver: The Role of Flow Dynamics, Organ Microarchitecture and Cellular Phenotype
Use of nanoparticles for the diagnosis and treatment of disease is impeded by poor targeting efficiency. The majority of the injected dose accumulates in the liver, where it persists over time. Nanoparticle clearance by this organ is problematic as an insufficient dose is available to reach the …