Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Monolayer cell culture"”.
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HPV E6 inhibits E6AP to regulate epithelial homeostasis by modulating keratinocyte differentiation commitment and YAP1 activation
… by modulating homeostasis of infected basal cell to ensure persistence. Using FUCCI and cell-cell competition assays, we established the role of two common viral targets of low-risk and high-risk E6 proteins, E6AP and NHERF1, on the key components of epithelial homeostasis: cell density, …
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Hybrid Microfluidic Sensing Platforms for Cancer Cell Study: Recent Advances and Future Prospects
The importance of mammalian cell culture is vividly seen in biotechnology, drug screening, and large-scale pharmaceuticals production. There have been numerous efforts in designing an automated cell culture system replicating the natural microenvironment of the cells to improve throughput analysis …
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Effective Cancer Therapy Design Through the Integration of Nanotechnology
… occurs, thereby imparting enhanced tumor cell viability and resistance to subsequent therapy treatments. Introducing nanoparticles (NPs), such as multi-walled nanotubes (MWNTs) or carbon nanohorns (CNHs), into target tissue prior to laser irradiation increases heating selectivity …
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The Influence of Human Umbilical Vein Endothelial Cells in the Formation of Glioblastoma Spheroids in Three-Dimensional Microwells
… (OVs). The studies with two-dimensional (2D) cell cultures have been used as physiological models for understanding the cellular and molecular behavior of the GBM tumors. They are also highly desirable for virus studies. However they may not provide threedimensional (3D) characteristics of the …
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Engineered 3D microenvironments to understand and direct liver progenitor and cancer cell fate
The cellular microenvironment encompasses every chemical and physical factor surrounding a cell, including all other cells, cell-cell and cell-extracellular matrix (ECM) signaling interactions and any detectible change in conditions. As the interplay between every component of the microenvironment …
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Modeling and simulation of non-linear bioelectronic systems applied to cell culture assays
… depending on the type of biological sample (cells, tissues, blood, etc.). In this thesis, we improve the accuracy of the ECIS (electrical cell-substrate impedance spectroscopy) technique of bioimpedance (BI) measurement of a monolayer cell-culture (CC), which measures the electrical response …
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Investigating Early Lesion Formation Following Papillomavirus Infection Using a Mouse Model and Cell Culture
… cycle. To further understand the mechanisms of cell persistence during PV infection, immunodeficient mouse tail samples inoculated with MmuPV1 were examined to investigate early lesion formation. Five discrete stages of lesion formation were characterised in the immunodeficient animals. In …
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Derivation of next generation research models of Parkinson’s disease
… region of the midbrain and the presence of intracellular inclusions, notably Lewy bodies composed of the alpha-synuclein protein (encoded by the SNCA gene), in the surviving neurons. The precise molecular and cellular mechanisms governing PD's onset, progression, and pathology remain incompletely …
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Cell and tissue engineering of articular cartilage via regulation and alignment of primary chondrocyte using manipulated transforming growth factors and ECM proteins. Effect of transforming growth factor-beta (TGF-¿1, 2 and 3) on the biological regulation and wound repair of chondrocyte monolayers with and without presence of ECM proteins.
… life is arthritis. Research on cartilage cell/tissue engineering will help patients to improve their physical activity by replacing or treating the diseased/damaged cartilage tissue. Cartilage cell, called chondrocyte is embedded in the matrix (Lacunae) and has round shape in vivo. The in …
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Cell and tissue engineering of articular cartilage via regulation and alignment of primary chondrocyte using manipulated transforming growth factors and ECM proteins. Effect of transforming growth factor-beta (TGF-¿1, 2 and 3) on the biological regulation and wound repair of chondrocyte monolayers with and without presence of ECM proteins.
… life is arthritis. Research on cartilage cell/tissue engineering will help patients to improve their physical activity by replacing or treating the diseased/damaged cartilage tissue. Cartilage cell, called chondrocyte is embedded in the matrix (Lacunae) and has round shape in vivo. The in …
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Cell and tissue engineering of articular cartilage via regulation and alignment of primary chondrocyte using manipulated transforming growth factors and ECM proteins. Effect of transforming growth factor-beta (TGF-¿1, 2 and 3) on the biological regulation and wound repair of chondrocyte monolayers with and without presence of ECM proteins.
… life is arthritis. Research on cartilage cell/tissue engineering will help patients to improve their physical activity by replacing or treating the diseased/damaged cartilage tissue. Cartilage cell, called chondrocyte is embedded in the matrix (Lacunae) and has round shape in vivo. The in …