Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 44 for “"Monocyte-derived macrophages"”.
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Regulation of HIV latency dynamics in monocytes and monocyte-derived macrophages
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2024-09-16 without embargo terms
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Effects of ARVs and HIV on mitochondrial function and immune activation in monocyte derived macrophages in vitro
While ART reduces HIV associated morbidity and mortality, low levels of persistent inflammation in virally suppressed individuals drive a form of accelerated aging and comorbidity. Macrophage activation drives persistent inflammation but the molecular mechanisms remain poorly understood. Uninfected …
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Modulation of macrophage function and immune response by a helminth-derived cysteine protease
Helminth-derived excretory/secretory (ES) products have been demonstrated to mediate the anti-inflammatory/regulatory environment associated with helminth infection (for a review see Allen et al. 2011). The ES products of helminths have been exploited for therapeutic benefit in both murine and …
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The Immune Modulatory Effects of Tylvalosin in Porcine Neutrophils and Macrophages in vitro
… its effects, in isolated neutrophils and monocyte-derived macrophages from piglets. Our findings indicate that TYL increases porcine neutrophil and macrophage apoptosis in a dose-dependent and time-dependent manners, without affecting levels of necrosis. TYL also modulates mediators of …
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Transmission Dynamics Of Mycobacterium Avium Subspecies Paratuberculosis In Closed Dairy Herds In The Us
… bovine-specific MAP strains but no difference in monocyte-derived macrophages from shedding and non-shedding exposed animals. Molecular analysis of strains of MAP in dam-daughter pairs in a seven-year longitudinal dataset showed that vertical transmission plays a small but identifiable role in MAP …
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Macrophages in vitro as a predictive model in polymer toxicology
… cultured rat NR8383 AM-like cells, human THP-1 monocyte cells or human monocyte derived macrophages were treated with polymer for 24 h and supernatants analysed for indicators of cytotoxicity and inflammatory mediator release. In addition, after 6 h treatment, gene changes in the rat lung tissue …
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Role of Macrophage Subsets in CD8+ T Cell Dysfunction in Chronic HCV Infection
… to HCV-specific CD8+ T cells. Infiltrating monocyte-derived macrophages contribute to a micro- environment that could impact CD8+T cells trafficking through the liver. Macrophages can differentiate into pro-inflammatory (M1) and anti-inflammatory (M2a, M2b, and M2c) subsets. Whether …
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Heterogeneity, Origins, and Role of Omental Macrophages in Health and Early Tumor Seeding
… and clearing pathogens. Tissue-resident macrophages (TRM) are innate immune cells that first appear at primitive hematopoiesis to facilitate fetal organ growth. After birth and depending on environmental cues, monocytes may replace a subset of embryonic-derived macrophages to …
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Modulation of Host BRD4 to Repress HIV Replication in Myeloid Cells: Major HIV Reservoirs in Central Nervous System
… microglia and myeloid cells (perivascular macrophages) are important HIV reservoirs in vivo, especially in central nerve system (CNS). Despite anti-retroviral therapy (ART), low-level persistent HIV replication in these reservoirs remains detectable, which contributes to neuroinflammation …
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The Role of Inflammation in the Pathobiology of TB/HIV Co-infection
… in co-infected HuMouse lung. Using primary human monocyte-derived macrophages (MDM) and an in vitro co-infection system, we further observed greater cell death and increased expression of pro-inflammatory cytokines in co-infected MDMs compared to mono-infection with either HIV-1 or M.tb. Analysis …
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NONCANONICAL PYROPTOSIS PROMOTES NONALCOHOLIC STEATOHEPATITIS VIA LIPID PEROXIDATION AND TRAINED IMMUNITY
… liver damage that drives NAFLD. Hepatic macrophages (HMΦ’s), which include resident Kupffer cells and monocyte-derived macrophages, are the primary drivers of liver inflammation in both human and mouse models. In macrophages, chronic lipid exposure promotes pro-inflammatory polarization …
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The Role of Inflammation in the Pathobiology of TB/HIV Co-infection
… in co-infected HuMouse lung. Using primary human monocyte-derived macrophages (MDM) and an in vitro co-infection system, we further observed greater cell death and increased expression of pro-inflammatory cytokines in co-infected MDMs compared to mono-infection with either HIV-1 or M.tb. Analysis …
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Human blood-derived extracellular vesicles in tendon tissue engineering and regenerative medicine applications
… therapeutic strategies based on Human blood-derived EVs as biochemical cues to promote tendon tissue repair. Blood-derived EVs were obtained from platelets (Chapter IV) and monocyte-derived macrophages (Chapter V), and their morphology, size, and protein content were thoroughly assessed. …
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Impact of cationic host defence peptide LL-37 on human neutrophil death and inflammatory responses
… necrosis did not affect PMN ingestion by human monocyte-derived macrophages and, in contrast to expectation, was not proinflammatory. Interestingly, the anti-inflammatory effects of apoptotic PMN on activated macrophages were retained and even potentiated where LL-37-mediated secondary necrosis …
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Characterization of the antiviral activity of cyclosporine A against dengue virus
… cells, Huh7 human hepatoma cells, and THP-1 monocyte-derived macrophages. We demonstrated that CsA effectively inhibits DENV-2 in all three cell types. Notably, the antiviral activity of CsA against DENV-2 is independent of its target proteins, cyclophilin A or B, which are not required host …
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Analysis of human cytomegalovirus in the healthy human carrier
… that the predominant site of persistence was the monocyte. In addition, analysis of healthy seronegative subjects revealed that a significant number (30%) also harbored HCMV. Finally, study of granulocytes demonstrated no evidence of persistent HCMV. Expression of HCMV during persistence was also …
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The Indirect Effect of BVDV on Immune Suppression: The Role of Infected Macrophages in Lymphocyte Apoptosis
… the indirect effect of BVDV infection in macrophages as a key player in the pathogenesis of BVD especially, the apoptotic effect induced on lymphocytes. We infected bovine monocyte-derived macrophages (MDM) with either high or low virulent strains of cytopathogenic or non-cytopathogenic …
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Chemotactic and inflammatory responses to and recognition of Encephalitozoon spp. of microsporidia
… is believed to occur through vehicular spread by macrophages. The macrophage response to microsporidia is poorly understood. The information, described herein, is focused on defining the host-pathogen interaction and subsequent inflammatory response in human monocyte-derived-macrophages (MDM) …
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Analysis of Macrophage-‐Derived Inflammatory Response in the Presence of Glycosaminoglycans: A Possible Clue on the Role of Inflammation in the Pathogenesis of Morquio A
… as well as some specific cell types such as macrophages. This suggests that MPS IVA is a systemic disease that may disrupt cellular homeostasis throughout the body. Recent work on mucopolysaccharidoses and KS has produced two opposing models to explain the repercussions of KS accumulation. …
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The effect of hypoxia on macrophage proteoglycans: potential role in atherosclerosis
… to modification and uptake by resident macrophages that are found in hypoxic sites in atherosclerotic lesions (with oxygen levels below 1%). PG are multifunctional proteins and in addition to their interaction with LDL, they bind and regulate the activity of growth factors and cytokines …
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