Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 340 for “"Monocyte"”.
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Monocyte adherence to fibronectin: role of CD11/CD18 integrins and relationship to other monocyte functions
Regulated adherence of monocytes to extracellular matrix macromolecules is a prerequisite for their accumulation at sites of pulmonary infection and inflammation. To begin to assess the pathobiological importance of alterations in monocyte adherence to extracellular matrix in inflammatory lung …
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Diversity among monocyte derived stromal cells
Fibrocytes are monocyte-derived cells that morphologically look like fibroblasts, express both stromal and haematopoietic markers, and have been reported as being involved in wound healing and fibrosis. In-vitro derived fibrocytes can be differentiated in both serum-containing and serum-free …
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Mediators of monocyte activity in inflammation
… within chronic inflammatory diseases is the monocyte. Monocytes are able to modulate inflammation through cytokine expression, cytosolic peroxide formation, adhesion molecule expression and subsequent adhesion/migration to sites of inflammation. CRP has been previously shown to bind directly …
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Phospholipase A2 Induced Monocyte Chemotaxis to Apoptotic Cells
… This process is mediated by phagocytes of the monocyte lineage. Before phagocytosis can occur, macrophages must be recruited to the apoptotic cells through chemotaxis. Products of the reaction catalyzed by the phospholipases A2 (PLA2) have been shown to induce monocyte chemotaxis either …
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Copper supplementation and monocyte function in growing beef calves
… or Cu-Lysine (CuLy) on Cu status and bovine monocyte function was evaluated through a series of experiments. Initially, two in vitro techniques, immunomagnetic (IM) and culture flask adherence (CF), were compared for isolation of a viable, homogeneous monocyte population. The CF technique for …
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UNCOVERING LNCRNA-CHROMATIN INTERACTIONS SHAPING HUMAN MONOCYTE TO MACROPHAGE DIFFERENTIATION
… lncRNAs in a dynamic model of monocyte to macrophage differentiation, a key process in innate immunity. To achieve this, we generated a comprehensive transcript annotation of the system using a novel approach that combines long-reads sequencing with transcription start site …
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The effect of age on human monocyte epigenetics and function
… looks specifically at a single cell type; monocytes rather than a tissue, such as blood, to characterise cell specific changes. Methylation changes were observed to be tissue and cell specific, so analysing them in a single cell type can better elucidate the mechanism by which it undergoes …
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Monocyte Modulation of Disease Pathogenesis and Progression in Localized Aggressive Periodontitis
… host inflammatory and immune responses. LAgP monocytes synthesize increased levels of the potent proinflammatory lipid mediator, Prostaglandin E2 (PGE2), preferentially differentiate into dendritic cells, and lead to increased IgG2 production. In addition, levels of Platelet Activating Factor …
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Regulation of Human Monocyte Function by Cross-Linking of Immunoglobulin E
… receptor on other innate immune cells, including monocytes, suggests that it may impact the function of these cells in allergic environments. Exacerbations of allergic disease have been associated with allergen exposure as well as viral and bacterial infection, but the mechanisms of these …
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Regulation of HIV latency dynamics in monocytes and monocyte-derived macrophages
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2024-09-16 without embargo terms
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Factors governing monocyte-macrophage physiology and function during atherosclerotic cardiovascular disease
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-12-01
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Targeting Innate Immune Memory to Alleviate Monocyte Exhaustion and Chronic Inflammation
… dysregulation. Innate immune cells, particularly monocytes, are key regulators of inflammation and its resolution. However, unbalanced or prolonged stimulation can drive these cells into dysfunctional states. These cells may enter dysfunctional "exhausted" or "low-grade inflammatory" states, …
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Dose-dependent effects of endotoxin on monocyte and the underlying mechanisms
Monocytes are dynamic innate immune cells that respond differently based upon the dose and duration of an infection. While super low dose endotoxin is found in chronic inflammatory diseases such as atherosclerosis, exposure to high dose endotoxin leads to sepsis. However, clear characterization of …
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Expression and regulation of monocyte chemoattractant protein-3 (MCP-3) in fibrosis
… thesis explores the expression of chemokine, monocyte chemoattractant protein-3 (MCP-3/CCL7) in SSc and in murine models for SSc: type 1 tight skin mouse (Tsk1) and a transgenic mouse strain (TβRIIΔk) in which there is fibroblast-directed disruption of TGFβ signalling. The hypothesis that …
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Factors That Influence Monocyte Differentiation and Hematopoietic Stem Cell Recruitment In Atherogenesis
… a disease characterized by the infiltration of monocytes into the vessel wall, their differentiation into phagocytic resident macrophages, and subsequent lipid uptake and accumulation causing plaque growth and atheroma formation. Hyperlipidemia and other risk factors for cardiovascular disease …
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Tumor-Derived Retinoic Acid Regulates Intratumoral Monocyte Differentiation To Promote Immune Suppression
… to immunotherapy. Within solid tumors, why monocytes preferentially differentiate into immunosuppressive tumor associated macrophages (TAMs) but not immunostimulatory dendritic cells (DCs) remains unclear. Using multiple murine sarcoma models, we found that the TME induced tumor cells to …
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Investigating defects in monocyte responses to Mycobacterium tuberculosis in HIV-TB co-infection
Includes abstract. Includes bibliographical references.
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Systems and Comparative Analyses of Monocyte Dynamics Based Upon Single Cell Sequencing Data
… often involve complex and dynamic responses of monocytes, crucial cells of the innate immune system. Understanding these responses, particularly to lipopolysaccharide (LPS), a key inflammatory stimulus, is vital yet remains challenging due to their heterogeneity and plasticity. Upon analyzing …
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