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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Monocrotaline"”.
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The pyrrolizidine alkaloids : studies on the pyrrolizidine base Retronecanol
… were performed on retronecanol1 obtained from monocrotaline, the alkaloid present in Crotalaria spectabilis. Previously two different theories regarding the biosynthesis of the pyrrolizidine bases had been proposed. Conflicting results in this school emphasised the need for a critical …
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Synthesis and biological evaluation of potential DNA cross-linking agents based on pyrrolizidine alkaloids
… pyrrolizidine progenitors developed from monocrotaline is discussed. The synthesis of a potential water soluble photolabile protecting group is also described. In addition, the biological evaluation of the synthesized pyrrolizidine progenitors was investigated.
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Induktion von myokardialem ER-Stress durch biomechanische Last und neurohumorale Stimulation.
… den rechten (RV) und linken (LV) Ventrikeln von Monocrotaline-behandelten Ratten und rechtsventrikulären Muskelstreifen, die verschiedenen Lastbedingungen und pharmakologischen Interventionen ausgesetzt wurden. Expression wurde durch Realtime-PCR ermittelt. Wir konnten zeigen, dass eine …
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Isolation, characterization, and functional assessment of novel smooth muscle like stem progenitors
… rats and also from the peripheral blood of monocrotaline induced pulmonary hypertension (MCT-PHTN) animal model. Characterization of novel SMSPC exhibited stem cell characteristics and machinery for differentiation into SMC. The expression of Isl-1 on SMSPC provided unique molecular identity …
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The Identification and Pharmacological Characterisation of Novel Apelin Receptor Agonists In Vitro and In Vivo
… not prevent pulmonary arterial hypertension in a monocrotaline rat model of the disease. An apelin mimetic peptide possessing an unnatural amino acid, MM202, conjugated chemically via a polyethylene glycol linker to an anti-serum domain antibody (AlbudAb) was also characterised. The product …
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Preclinical Investigation of Mitochondrial Fission Inhibitors in Pulmonary Arterial Hypertension and Non-Small Cell Lung Cancer
… annexin V assays, though Compound 6 did not. The monocrotaline (MCT) model of PAH (MCT-PAH) was created in female Sprague-Dawley rats by a single subcutaneous injection of MCT (60 mg/kg). 1 mg/kg Drpitor1a treatment in MCT-PAH over 12 days regressed vascular remodeling, improved hemodynamics, and …
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Melatonin as a novel cardioprotective therapy in pulmonary hypertension
… of PH induced 28 days after the injection of monocrotaline (MCT, 80mg/kg, subcutaneous) (n≥6). Melatonin (75ng/L, nutritional concentration), 4mg/kg or 6mg/kg (therapeutic dose) was given daily in the drinking water of rats, with the treatment started 5 days before the injection of MCT, on the …
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Potential cardioprotective effect of chronic, moderate consumption of reduced-alcohol wine in a rat model of pulmonary hypertension
… or regular red wine (RW) consumption would limit monocrotaline (MCT)-induced PAH in rats. Methods: Long Evans male rats (150-175g) were randomly assigned into 6 groups: (1) Control: no subcutaneous injection of MCT; (2) MCT; (3) RARW; (4) MCT-Treated with RARW: 5.5% alcohol red wine (5) RW and (6) …