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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 331 for “"Monoclonal antibody"”.

  1. Genentech: Purification of Monoclonal Antibody

    Salmon, ArielleUniversity of Nevada, Reno2017

    Lucentis, a monoclonal antibody fragment produced in Escherichia coli, is used to treat wet age-related macular degeneration, one of the leading causes of legal blindness. The objective of this thesis is to analyze the process of antibody fragment separation and to purify a solution of "Lucentis …

    unr Repository record

  2. Intracellular delivery of rabbit monoclonal antibody

    Qian, Qi2018

    … demand. Recently, an increasing number of rabbit monoclonal antibodies (RabMAbs) have been approved to able to recognize subtle distinctions between the changes of intracellular proteins status. They could be good tools for researchers with the ability to traverse through cell membrane into living …

    u-pacific Repository record

  3. Cost modeling for monoclonal antibody manufacturing

    Simpson, Christina M. (Christina Margaret)Massachusetts Institute of Technology2011

    … manufacturing large molecule products, including monoclonal antibodies, for late stage clinical trials and commercial sales. The BioPharmOps site in Huningue, France is expanding their product line but is also trying to reduce costs; cost pressures are increasing as biotech products become a …

    mit Repository record

  4. Monoclonal antibody development to a new opiate receptor

    Fein, Jeffrey

    sjsu Repository record

  5. Targeting Proteins of Aspergillus fumigatus for Monoclonal Antibody Production

    Moschetti, Anthony S.2014

    IA is increasingly prevalent and problematic among patients with immunodeficiency. Early diagnosis of IA can be difficult because the symptoms patients display are not specific to fungal infections, and the diagnostic tests currently in use are unreliable. It is well known that the organisms that …

    unr Repository record

  6. Investigation of Inter-Individual Variability in Monoclonal Antibody Disposition

    Thomas, Veena; 0000-0002-5202-6697State University of New York at Buffalo2018

    Ph.D.

    buffalo Repository record

  7. Radioimmunotargeting of Renal Cell Cancer using Monoclonal Antibody cG250.

    Brouwers, A.H.S.l. : s.n.2004

    Contains fulltext : 58758.pdf (Publisher’s version ) (Open Access)

    radboud Repository record

  8. Monoclonal antibody (mAb) purification by counter current chromatography (CCC)

    Fernando, SamanthaBrunel University School of Engineering and Design PhD Theses2011

    … extended to the rapid, scalable purification of monoclonal antibodies (mAb) from mammalian cell culture, using aqueous two-phase systems (ATPS) of inorganic salts and polymer. A polyethylene glycol (PEG) and sodium citrate system was found to be the most appropriate by robotic phase system …

    brunel Repository record

  9. Monoclonal Antibody Expression and Novel Purification in Nicotiana benthamiana

    Fulton, Andrew DaleVirginia Tech2011

    … alike have realized the vast potential of monoclonal antibodies to treat diseases ranging from arthritis, immune and infectious diseases to cancer. There are a number of antibodies on the market that constitute a large portion of the biopharmaceutical niche in the drug industry. Blockbuster …

    vt Repository record

  10. Targeting the Tumor Stroma Using a Monoclonal Antibody Platform Technology

    Hintz, Hallie2021

    … we document the discovery and validation of a monoclonal antibody that selectively binds to FAP. The lead antibody, B12, was identified from a naïve murine single-chain variable fragment antibody phage display library screened against recombinant human FAP. The heavy and light chains of B12 …

    umn Repository record

  11. Development of monoclonal antibody cell culture processes and antibody characterisation

    Gogia, ShreyaUniversity College Cork2025

    Monoclonal antibodies (mAbs) have transformed modern therapeutics due to their high specificity and efficacy for a wide range of diseases. This research project aimed to establish an end-to-end laboratory-scale monoclonal antibody production process, including upstream cell culture, downstream …

    cork Repository record

  12. Studies on the Function of Human Anti-HSP60 Monoclonal Antibody Fab

    장, 은정2011

    "목적 : 열충격 단백질(Heat Shock Protein; HSP)은 원핵 세포과 진핵 세포에서 발현된다. 열충격 단백질은 단백질이 합성될 때 올바른 접힘을 돕는 chaperone의 역할을 하며 분자량에 따라 나뉠 수 있다. 그 중에서 열충격 단백질-60은 열과 같은 충격에 의하여 미토콘드리아 내에서 발현 양이 증가되고, 세포 표면에서도 발현될 수 있다. 열충격 단백질-60은 다양한 미생물질에 의한 선천적 면역 체계 활성체 및 염증 반응 자극제로서 작용한다고 알려졌다. 인간 재조합 열충격 단백질-60은 면역 세포에서 염증 반응을 …

    ajou Repository record

  13. Molecular dynamics of monoclonal antibody production in high density perfused bioreactors

    Buser, Claudia WaltrautMassachusetts Institute of Technology1992

    Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Applied Biological Sciences, 1992.

    mit Repository record

  14. THE RELATIONSHIP BETWEEN MONOCLONAL ANTIBODY THERAPIES, PHARMACOKINETICS AND VITAMIN D-RELATED MARKERS

    Roccatello, Dario, D'Avolio, Antonio, Cusato, JessicaUniversità degli Studi di Torino2019

    unito Repository record

  15. MOLECULAR ROLES OF HSP27 IN IMPROVING MONOCLONAL ANTIBODY PRODUCTION OF CHO CELLS

    TAN GEK LING JANICE2014

    … BIOLOGICS INCLUDING THE RAPIDLY EXPANDING MONOCLONAL ANTIBODIES (MAB) AND BIOSIMILARS. THERE ARE OPPORTUNITIES TO EXPLORE THE USE OF ENGINEERED CHO CELL LINES WITH IMPROVED RECOMBINANT BIOLOGICS CAPABILITIES. HEAT SHOCK PROTEIN 27 (HSP27) WAS REPORTED TO BE HIGHLY EXPRESSED IN HUMAN CELLS …

    nus Repository record

  16. The biochemical dynamics of monoclonal antibody production in high density perfused fermentors

    Tyo, Michael Alexander.Massachusetts Institute of Technology1992

    Thesis: Ph. D., Massachusetts Institute of Technology, Department of Applied Biological Sciences, 1992

    mit Repository record

  17. Optimisation of analytical methods for monitoring monoclonal antibody therapy in Inflammatory Bowel Disease

    Rachel Nice (21040325)2026

    … (GI) tract can be successfully treated with the monoclonal antibody therapies Infliximab and adalimumab. However, low drug levels and immunogenicity (development of anti-drug antibodies) are associated with treatment failure. Therapeutic drug monitoring, using drug and anti-drug antibody …

    exeter

  18. Production and Characterization of an Human Monoclonal Antibody IgG to TRAIL Receptor 2

    유, 화니2012

    … 효과적이며 안정적인 치료용 항체로 만들기 위해 Fab 를 IgG 형태로 바꾸었다. 이는 antibody engineering을 통하여 DR5-18 IgG construct를 제작하는 방법으로 수행되었으며, 포유 세포에 넣어 항체 발현을 할 수 있도록 만들어졌다. 본 학위논문 연구에서는 발현된 DR5-18 IgG를 배양액으로부터 AKTA prime plus 와 HitrapTM IMAC column을 이용하여 정제하였으며 western blotting을 통해 확인하였다. MTT assay, Annexin V-FITC/PI …

    ajou Repository record

  19. Development of a novel monoclonal antibody-based immunoaffinity column for the detction of aflatoxins

    Henderson, Sarah-JayneUniversity of Strathclyde2010

    1G7-1E2 is a novel monoclonal antibody, created at the University of Strathclyde in Glasgow. Several IG7-1E2 antibodies were produced by poly ethylene gycol fusion of mouse myeloma cells with sensitised spleen cells isolated from Balb c/NZB F1 hybrid mice immunised intraperitoneally with aflatoxin …

    strathclyde Repository record

  20. New therapeutic and diagnostic strategies in glioblastoma: Cancer Stem Cells targeted by monoclonal antibody

    SCIUTO, MARIA RITAUniversità degli studi di Catania2013

    … glioblastoma multiforme (GBM) by generating monoclonal antibodies (mAbs). Glioblastoma multiforme is the most common and most aggressive malignant primary brain tumor in humans. Even after treatments based on multiple approaches, as radiotherapy, surgical resection and chemotherapy, the …

    catania Repository record

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