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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 367 for “"Monoclonal Antibodies"”.
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Radioimmunotherapy using 186Relabeled humanized monoclonal antibodies.
Contains fulltext : 58759.pdf (Publisher’s version ) (Open Access)
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Production of recombinant monoclonal antibodies against HSET
… of HSET in cancer cells, we produced mouse monoclonal antibodies (mAbs) against HSET using a hybridoma technique and characterized them. Peptide antigens of 12 amino acid (aa)-length, designed from the regions corresponding to N-terminus (1-134th aa) and C-terminus (626-672th aa) that do not …
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Modeling approaches to characterize the disposition of monoclonal antibodies
Monoclonal antibodies (mAbs) are engineered immunoglobulins G (IgG) used for more than 20 years as targeted therapy in oncology, infectious diseases and (auto-)immune disorders. Their protein nature greatly influences their pharmacokinetics (PK), presenting typical linear and non-linear behaviors. …
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Monoclonal antibodies against Neisseria Gonorrhoeae: serotyping and diagnostic applications
… (i) to investigate the value of newly developed monoclonal antibody coagglutination reagents for serotyping gonococci according to Protein I variation between strains; (ii) to determine if these or similar monoclonal antibodies could be used in an immunological method for the non -cultural …
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Production of Monoclonal Antibodies for Toxoplasma gondii Lactate Dehydrogenase
… the first of all, hybridoma cell lines producing monoclonal antibodies with high affinity and specificity against T. gondii LDH (TgLDH) were established. Methods: After 6-8 week old BALB/c mice were immunized with synthetic peptides of TgLDH, splenocytes were harvested. To get the monoclonal …
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DEVELOPMENT AND CHARACTERIZATION OF NOVEL MONOCLONAL ANTIBODIES TARGETING CARBOHYDRATE ANTIGENS IN CANCER
… description by Kohler and Milstein in 1975, monoclonal antibodies (mAbs) have quickly become a key component in the select targeting, blocking and clearance of many diseases by the immune system. Today mAbs constitute the fastest growing segment of immunotherapy in the diagnosis and treatment …
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Population Pharmacokinetics of Therapeutic Monoclonal Antibodies: Examples and Estimation Method Performance Differences
… and development and therapeutic application of monoclonal antibodies (mAbs). An application of pharmacokinetic (PK) and pharmacodynamic concepts that has likely contributed to the success of the pre-clinical and clinical drug development of therapeutic mAbs is population PK, which attempts to …
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Development of highly specific monoclonal antibodies to Listeria sp. and Listeria monocytogenes
The aim of this study was to develop monoclonal and polyclonal antibodies against Listeria spp., a selective culture broth, and an immunoassay to enable a 21 hour assay to detect Listeria spp. in foodstuffs. Listeria is a common contaminant of food production. Its hardiness and ability to grow …
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Efficiency of Monoclonal Antibodies to Detect Respiratory Virus Antigens in Clinical Specimens
… efficiency of immunofluorescent assay employing monoclonal antibodies from commercial sources to detect respiratory virus antigens in clinical specimens and to define the epidemiology of respiratory viruses in Bismarck, North Dakota.</p> <p>Throat swab, nasopharyngeal swabs and nasopharyngeal …
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Characterisation of a harvesting step for monoclonal antibodies from mammalian cell culture
… employed to clarify culture broth containing monoclonal antibodies secreted by GS-NSO cells: the filtration train blinded unpredictably and the ability of the positively charged filters to adsorb DNA from process material was unknown. To direct the development of an assay to quantify the …
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In silico redesign and de novo design of anti-MUC1 monoclonal antibodies
… and treatment of epithelial cancers via antibodies. While anti-MUC1 monoclonal antibodies do exist, none have proven to be effective in clinical trials. Antibody fragments have been identified as possible therapeutic agents since their small molecular weight and improved selectivity allow …
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