Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Monocarboxylate Transporter"”.
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The role of Thyroid hormone Transporters Monocarboxylate Transporter 10 (MCT10) and Monocarboxylate Transporter 8 (MCT8) in extravillous trophoblasts.
… important for fetal and placental development. Monocarboxylate transporters 8 and 10 (MCT8, MCT10) are effective plasma membrane TH transporters expressed in the human placenta from 6 weeks of gestation. Both have been localized to human villous trophoblasts and extravillous trophoblasts (EVTs). …
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Role of Monocarboxylate transporter in lung development and lung cancer
… pH (pHi) could be carried out by a family of transporters which are H+- monocarboxylate co-transporters, known as monocarboxylate transporters (MCTs). These studies show evidence for the expression of MCTs during early development of human and mouse embryos and in embryo pre-implantation. As …
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Biochemical Thermodynamic Modelling of Cellular Bioenergetics: A Quantitative Systems Pharmacology Approach
… flux, used to determine the role of the monocarboxylate transporter 1 flux during extracellular acidification. Finally, chapter 4 describes a thermodynamic-based in silico model of mitochondrial bioenergetics, capable of simulating oxygen consumption rates of a cohort of in vitro human …
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Postmortem metabolism in porcine skeletal muscle
… in or out of tissues by proton-linked iii monocarboxylate transporters (MCTs). Previous reports indicated that acute activation of AMPK increased monocarboxylate transporter expression in skeletal muscle of other species. Yet, it was unknown the impact chronic activation of AMPK will have …
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Developing an adjunct therapy to mechanical thrombectomy in a murine model of stroke ischaemia reperfusion injury
… (DSM) has been reported to enter cells via monocarboxylate transporter 1 (MCT1) to inhibit RET-ROS and reduce IR injury. The uptake and efficacy of DSM can be enhanced by low pH, which increases the proportion of its monocarboxylate form, the substrate for MCT1. Therefore, the main aim of …
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Metabolic changes in cellular components of the vasculature : examining the link between diabetes and cancer
… the release of lactate from the cell through the monocarboxylate transporter (MCT1).Lastly, the metabolic changes that occur in healthy endothelial cells in normal and elevated glucose environments are compared to those same changes in cancerous HeLa cells. The endothelial cells had an increased …
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Thyroid hormone action and disruption in the brain: Xenopus as a model to study disruption of thyroid hormone availability on early brain development
… in humans, the mutation of the brain specific TH transporter (THT), monocarboxylate transporter 8 (MCT8), leads to severe intellectual disability. The lack of neurological phenotype in mice model of Mct8 deficiency has driven the need for characterisation and generation of various non-rodent …
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Metabolic Exogenous Contrast Agents for use in Breast Cancer Detection and Therapy Monitoring
… a-Cinn stimulates glycolysis by inhibiting the monocarboxylate transporter 1 preventing lactate from entering as a source for oxidative phosphorylation. 2-NBDG was concurrently increased after a-Cinn treatment. Observation of changes in downstream glycolysis has been determined after the …
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Cooperativity: Physiologic Cornerstone and Emerging Therapeutic Design Principle
The content of this work is based on the previously published articles that are cited below.