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Showing 1 to 20 of 31 for “"Monoamines"”.
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Stress, Monoamines, and Cognitive Flexibility
Stress has been implicated in psychiatric disorders that are characterized by impaired executive function, which is mediated by the prefrontal cortex (PFC). The stress-related neuropeptide, corticotropin-releasing factor (CRF) regulates monoamine systems that project to the PFC, including the locus …
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The nucleus infundibularis of the human hypothalamus: structure, monoamines, karyometrics
Contains fulltext : mmubn000001_233084983.pdf (Publisher’s version ) (Open Access)
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The Effect of Organophosphate Exposure on Neocortical, Hippocampal and Striatal Monoamines: A Potential Substrate for Chronic Psychiatric, Cognitive and Motor Dysfunction
… may alter the synthesis or release of monoamines through prolonged action of ACh on monoaminergic neurons that contain ACh receptors. Adult, male Sprague-Dawley rats were subjected to a single subcutaneous dose of CPS or corn oil vehicle. Brains were rapidly removed and the frontal …
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Neuropeptides Amplify and Focus the Monoaminergic Inhibition of Nociception in <i>Caenorhabditis elegans</i>
… the release of a complex mix of “inhibitory” monoamines, including OA and dopamine (DA), and neuropeptides from an array of additional neurons. For example, TYRA-3 stimulates the release of neuropeptides encoded by <i>nlp- 1</i>, <i>nlp-14</i> and <i>nlp-18</i> from axons of the two ASI …
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Monoaminergic Signaling in the Human Brain: New Insights
… remains a central challenge in neuroscience. The monoamines dopamine, serotonin and norepinephrine uniquely contribute to neural computations throughout the forebrain, influencing attention, learning and decision-making. However, resolving these monoaminergic signals at physiologically and …
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Part I. Isoindolin-1-One Receptors for CG Base Pairs in a DNA Triple Helix. Part II. Cross-Linked Dendrimer Hosts Containing Reporter Groups for Amine Guests
… 53 to 85-fold more tightly than it binds monoamines. Furthermore, an assay of the dendrimer with several amine and alcohol guests indicated that it has high selectivity for guests most similar to its original template. However, control studies indicated that this selectivity is due to …
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Redox Regulation of Type Iα PKA in the Heart
… of monoamine oxidase (MAO), which metabolises monoamines to generate hydrogen peroxide (H2O2), blocked monoamine-induced RIα oxidation. Echocardiography revealed that RIαCys17Ser „redox-dead‟ knock-in (KI) mouse (which I verified cannot form disulfides) hearts had larger left ventricles during …
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Effect of antidepressants and adolescent stress on catecholamine transmission in the rat bed nucleus of stria terminalis (BNST): a microdialysis study
… that increase the synaptic concentration of monoamines, mostly through neurotransmitter reuptake blockade. The bed nucleus of stria terminalis (BNST) is considered a relay station in mediating the activation of stress response but also in the acquisition and expression of emotions. Chronic …
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MUTATION OF THE VESICULAR MONOAMINE TRANSPORTER-1 GENE ALTERS ITS PROTEIN PRODUCT
… 1 (VMAT1) is essential for storage of monoamines, such as epinephrine and serotonin, in secretory vesicles of neuroendocrine cells. Recently the VMAT1 protein was detected in human and mouse brain, and mutations of the VMAT1 gene at single DNA nucleotides (single nucleotide …
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I. Advanced Fluorescent False Neurotransmitters for the Study of Monoamine Transporter Activity and Synaptic Transmission
… is evaluated as a potential tracer of monoamines in the brain. It has been determined that while this molecule may have utility as a marker for monoaminergic neurons, APP+ is not an appropriate FFN due to high background labeling of mitochondria and other intracellular structures. …
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Structural Determinants of Post-transcriptional Protein Regulation as Modulators of Monoamine Signaling
<p>Monoamines were first discovered at the end of the 19th century when William Bates identified epinephrine (EPI) and noted its hemostatic effects. During the 20th century, norepinephrine (NE), dopamine (DA), and serotonin (5HT) were discovered in both the periphery and the brain. Due, in part, to …
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Studies into the ion exchange and intercalation properties of AlH2P3O10•2H2O
… amounts and angles of intercalation of simple monoamines and the effects of pK\(_b\) and sterics upon an amines ability to intercalate into AlTP. In addition, intercalation with silver exchanged AlTP was also found to be possible. This was able to intercalate several similar amines to AlTP, but …
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Building and characterising the neuropeptidergic connectome of Caenorhabditis elegans
… This synaptic circuitry is further modulated by monoamines and neuropeptides, which primarily act through extrasynaptic volume transmission. Neuromodulation is critical to nervous system function in all species, yet little is known about the structure and function of extrasynaptic signalling …
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EFFECTS OF CHRONIC METHYLPHENIDATE ON DOPAMINE/SEROTONIN INTERACTIONS IN THE MESOLIMBIC DOPAMINE SYSTEM OF THE MOUSE
… (NE) transporters to increase extracellular monoamines. Abuse rates of MPH are increasing as prescription rates increase, but the effects of high-dose, chronic MPH exposure have not been well defined. In particular, the effects of MPH on serotonin (5-HT) systems have not been well …
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Improvements in the Performance and Understanding of Switchable-Hydrophilicity Solvents
… be more completely separated from solutes than monoamines, resulting in a more pure isolated solute after a SHS-based separation. A virtual screening approach to the design of SHSs is presented that can be used to rapidly screen thousands of compounds to identify those that are estimated to be …
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Localizing engrams of olfactory memories in Drosophila
… different events. It is shown that two different monoamines are specificaly necessary for formation of either of these memories, dopamine in case of electric shock and octopamine in case of sugar memory, respectively. Taking the representation of the olfactory cue within the mushroom bodies into …
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Maternal separation in the rat : long-term effects of early life events on emotionality, drug response and neurobiology
… offspring. Furthermore, brain opioid peptides, monoamines, corticosterone levels and weight of adrenal and thymus glands were measured. When separating pups as intact litters kept in incubators, there were mainly no alterations in emotionality, amphetamine-induced locomotor activity, opioid …
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Characterization of Vesicular Monoamine Transporter 2 and Its Role In Parkinson'S Disease Pathogenesis Using Drosophila
… is essential for proper vesicular storage of monoamines such as DA and their regulated release. Increasing evidence have linked VMAT dysfunction with Parkinson’s disease. In this study, we re-examine the gain- and loss-of-function phenotypes of the sole VMAT homologue in <em>Drosophila</em>. …
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