Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"Monoamine transporters"”.
-
Design, synthesis, and evaluation of rigid probes for the monoamine transporters.
… and evaluation of rigid probes for the monoamine transporters.
-
The Role Of Sertonin And Vesicular Monoamine Transporters In The Adverse Responses To Methylenedioxymethamphetamine
… in nature. MDMA initially causes synaptic monoamine release, primarily of serotonin (5-HT), producing hyperthermia and hyperactivity (5-HT syndrome). Conversely, the long-term effects of MDMA manifest as a prolonged depletion in 5-HT, and structural damage to serotonergic nerve terminals. …
-
I. Advanced Fluorescent False Neurotransmitters for the Study of Monoamine Transporter Activity and Synaptic Transmission
… of fluorescent optical tracers of monoamine neurotransmitters for use in the study of monoamine transporter activity and distribution, as well as synaptic transmission in the brain. The second section details early studies concerning experimental therapeutics recently identified by …
-
Synthesis and Biological Evaluation of Rigid Analogues of Methamphetamines
… and benzyliazetidine analogs were evaluated at monoamine transporters as a part of preliminary structure-activity study for the development of novel monoamine transporter ligands. The binding affinities of the azetidine analogs were determined at dopamine (DAT) and serotonin (SERT) transporters …
-
Synthesis And Evaluation Of Novel Tropane Compounds As Potential Therapeutics For Drug Abuse
… which could exhibit equipotent affinities at the monoamine transporters for dopamine, serotonin and norepinephrine. A short and efficient synthetic methodology was developed for the synthesis of unique compounds which could exhibit potency for both the dopamine and serotonin transporters. The …
-
Design and evaluation of novel PET and SPECT tracers for imaging the monoamine system and the P-gp transporter
… towards two different brain elements, being the monoamine system and the P-gp transporter, were developed and evaluated in vivo. The first objective of this thesis was the design of radiotracers for the monoamine system more specifically, the norepinephrine transporter, monoamine oxidase and …
-
Monoamine Transporter Photoaffinity Ligands Based On Methylphenidate and Citalopram: Rational Design, Chemical Synthesis, and Biochemical Application
Monoamine transporters (MATs) are a family of proteins that include the dopamine transporter (DAT), serotonin transporter (SERT), and norepinephrine transporter (NET). Specifically, dysregulation of MAT function is associated with a host of disease states including drug abuse, major depressive …
-
Structural Determinants of Post-transcriptional Protein Regulation as Modulators of Monoamine Signaling
<p>Monoamines were first discovered at the end of the 19th century when William Bates identified epinephrine (EPI) and noted its hemostatic effects. During the 20th century, norepinephrine (NE), dopamine (DA), and serotonin (5HT) were discovered in both the periphery and the brain. Due, in part, to …
-
Computational Ligand-Based CNS Therapeutic Design: The Search for Novel-Scaffold Norepinephrine Transporter Inhibitors
Monoamine transporter (MAT) proteins are responsible for regulating cellular signal transduction through control of neurotransmitter reuptake in the synapse, and are therefore relevant to diseases including addiction, psychosis, anxiety and depression. MATs, specifically the serotonin transporter …