Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Monoamine transporter"”.
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MUTATION OF THE VESICULAR MONOAMINE TRANSPORTER-1 GENE ALTERS ITS PROTEIN PRODUCT
The vesicular monoamine transporter 1 (VMAT1) is essential for storage of monoamines, such as epinephrine and serotonin, in secretory vesicles of neuroendocrine cells. Recently the VMAT1 protein was detected in human and mouse brain, and mutations of the VMAT1 gene at single DNA nucleotides (single …
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Characterization of Vesicular Monoamine Transporter 2 and Its Role In Parkinson'S Disease Pathogenesis Using Drosophila
… role in selective neuronal loss in PD. Vesicular Monoamine Transporter (VMAT) is essential for proper vesicular storage of monoamines such as DA and their regulated release. Increasing evidence have linked VMAT dysfunction with Parkinson’s disease. In this study, we re-examine the gain- and …
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I. Advanced Fluorescent False Neurotransmitters for the Study of Monoamine Transporter Activity and Synaptic Transmission
… of fluorescent optical tracers of monoamine neurotransmitters for use in the study of monoamine transporter activity and distribution, as well as synaptic transmission in the brain. The second section details early studies concerning experimental therapeutics recently identified by …
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Monoamine Transporter Photoaffinity Ligands Based On Methylphenidate and Citalopram: Rational Design, Chemical Synthesis, and Biochemical Application
Monoamine transporters (MATs) are a family of proteins that include the dopamine transporter (DAT), serotonin transporter (SERT), and norepinephrine transporter (NET). Specifically, dysregulation of MAT function is associated with a host of disease states including drug abuse, major depressive …
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FUNCTIONAL AND BIOCHEMICAL CONSEQUENCES OF SINGLE NUCLEOTIDE POLYMORPHISMS IN THE HUMAN VESICULAR MONOAMINE TRANSPORTER 1 GENE (SLC18A1) By Sally Gamal Shukry, B.S.
… NUCLEOTIDE POLYMORPHISMS IN THE HUMAN VESICULAR MONOAMINE TRANSPORTER 1 GENE (SLC18A1) By Sally Gamal Shukry, B.S. A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science in Biology at Virginia Commonwealth University. Virginia Commonwealth University, …
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The Role Of Sertonin And Vesicular Monoamine Transporters In The Adverse Responses To Methylenedioxymethamphetamine
… in nature. MDMA initially causes synaptic monoamine release, primarily of serotonin (5-HT), producing hyperthermia and hyperactivity (5-HT syndrome). Conversely, the long-term effects of MDMA manifest as a prolonged depletion in 5-HT, and structural damage to serotonergic nerve terminals. …
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Structural Determinants of Post-transcriptional Protein Regulation as Modulators of Monoamine Signaling
<p>Monoamines were first discovered at the end of the 19th century when William Bates identified epinephrine (EPI) and noted its hemostatic effects. During the 20th century, norepinephrine (NE), dopamine (DA), and serotonin (5HT) were discovered in both the periphery and the brain. Due, in part, to …
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Synthesis and Biological Evaluation of Rigid Analogues of Methamphetamines
… and benzyliazetidine analogs were evaluated at monoamine transporters as a part of preliminary structure-activity study for the development of novel monoamine transporter ligands. The binding affinities of the azetidine analogs were determined at dopamine (DAT) and serotonin (SERT) transporters …
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CHRONIC LOW-LEVEL LEAD EXPOSURE AFFECTS THE MONOAMINERGIC SYSTEM IN THE MOUSE SUPERIOR OLIVARY COMPLEX
… mice were immunostained for the vesicular monoamine transporter 2 (VMAT2), serotonin, and dopamine beta hydroxylase (DβH, a marker for norepinephrine) in order to elucidate the effect of Pb on monoaminergic input into the SOC. In addition, sections were immunolabeled with antibodies to …
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CHRONIC LOW-LEVEL LEAD EXPOSURE AFFECTS THE MONOAMINERGIC SYSTEM IN THE MOUSE SUPERIOR OLIVARY COMPLEX
… mice were immunostained for the vesicular monoamine transporter 2 (VMAT2), serotonin, and dopamine beta hydroxylase (DβH, a marker for norepinephrine) in order to elucidate the effect of Pb on monoaminergic input into the SOC. In addition, sections were immunolabeled with antibodies to …
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Platelet Dense Granules Mature Within Late Stages Of Megakaryocyte Differentiation By Cargo Delivery
… the putative DG transmembrane protein vesicular monoamine transporter 2 (VMAT2) and its localization throughout MK differentiation. VMAT2 has been implicated as the transporter responsible for serotonin uptake into DGs and is therefore a likely candidate for a DG protein. Within MKs, VMAT2 …
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Pharmacological Characterization of Novel Serotonin Transporter Inhibitors Identified Through Computational Structure-Based Virtual Screening
… last 40 years. The SSRIs target the serotonin transporter (SERT), a monoamine transporter (MAT) responsible for terminating serotonergic neurotransmission. The SSRIs are not perfect therapeutics and suffer from delayed response times, inconsistent efficacy among patients, and often produce …
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Computational Ligand-Based CNS Therapeutic Design: The Search for Novel-Scaffold Norepinephrine Transporter Inhibitors
Monoamine transporter (MAT) proteins are responsible for regulating cellular signal transduction through control of neurotransmitter reuptake in the synapse, and are therefore relevant to diseases including addiction, psychosis, anxiety and depression. MATs, specifically the serotonin transporter …
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The nongenomic effects of physiological and environmental estrogens on dopamine transporter function
… regulatory machinery such as the dopamine transporter (DAT). In this dissertation we tested the rapid nongenomic effects of several physiological estrogens [estradiol (E2) estrone (E1), and estriol (E3)] and xenoestrogens (XEs), such as organochlorine pesticides [dieldrin, endosulfan, and …
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Analysis Of The Role Of Amphetamine In The Induction Of Changes In Histone Modifications Of Dopaminergic Pathway Genes
… regulates the expression of dat-1, the dopamine transporter and cat-1, vesicular monoamine transporter by reducing the enrichment of tri-methylated H3K4. Amphetamine treatment also increases the expression of cat-2, tyrosine hydroxylase by reducing the enrichment of tri-methylated H3K27.Our …
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Ligand-based drug design : I. conformational studies of GBR 12909 analogs as cocaine antagonists; II. 3d-QSAR studies of salvinorin a analogs as kappa opioid agonists
… of membrane-bound proteins (for example, monoamine transporter proteins and opioid receptor proteins) are unknown as these proteins are notoriously difficult to crystallize. In Part I of this study, analogs of the flexible dopamine reuptake inhibitor, GBR 12909, may have potential …
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Molecular and Neurochemical Effects of Methylphenidate on the Developing Brain
… effects of acute and chronic MPH treatment on monoaminergic protein markers, genes and their corresponding proteins involved in synaptic plasticity, as well as the drug’s effect on metabolic pathways. The investigations were conducted on brain regions implicated in the symptoms of ADHD in …
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Design and evaluation of novel PET and SPECT tracers for imaging the monoamine system and the P-gp transporter
… towards two different brain elements, being the monoamine system and the P-gp transporter, were developed and evaluated in vivo. The first objective of this thesis was the design of radiotracers for the monoamine system more specifically, the norepinephrine transporter, monoamine oxidase and …
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Assoziationsstudien von Kandidatengenen (VMAT2, DAT, BDNF) mit Persönlichkeitsmerkmalen und psychiatrischen Erkrankungen
… Kandidatengene (vesikulärer Monoamintransporter VMAT2, Dopamintransporter DAT, Brain Derived Neurotrophic Factor BDNF) bei Persönlichkeitsmerkmalen und psychiatrischen Erkrankungen näher zu beleuchten. C. Robert Cloninger postuliert in seiner biosozialen Persönlichkeitstheorie eine …