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Showing 1 to 20 of 52 for “"Monoamine oxidase"”.
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Monoamine oxidase in neuronal cell death
Monoamine oxidase (MAO) is an oxidative enzyme that deaminates a variety of amine substrates, including the neurotransmitter dopamine. The enzymatic reaction requires molecular oxygen and produces hydrogen peroxide as a by-product. MAO is localised in the outer mitochondrial membrane and exists as …
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Studies on monoamine oxidase in avian brain
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Monoamine Oxidase and Sensory Gating: Psychophysiological Vulnerabilities among Teenage Smokers
… focused on the role of the variable of monoamine oxidase-B (MAO-B) in the correlations among sensory gating, MAO and other cognitive and personality measures. All smokers were divided into high and low MAO groups first. Comparison analyses were conducted between them. The high MAO group …
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Some Studies on the Purification and the Properties of Monoamine Oxidase
Attempts were made to purify rat liver mitochondrial MAO in a single step by affinity chromatography. Except for tryptamine and serotonin-Sepharose, which irreversibly bound the enzyme, most adsorbents bound little if any of the enzyme. This was true for both detergent (triton X-100 and digitonin) …
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Characterization of a novel interaction between presenilin-1 and monoamine oxidase-A
The enzyme monoamine oxidase (MAO) is linked to mental disorders such as depression and neurodegenerative diseases. Our laboratory has recently demonstrated that increases in calcium (Ca²⁺) can enhance MAO activity and that this might contribute to Alzheimer disease (AD). AD has been linked to …
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Flavin Amine Oxidases from the Monoamine Oxidase Structural Family Utilize a Hydride Transfer Mechanism
The amine oxidase family of enzymes has been the center of numerous mechanistic studies because of the medical relevance of the reactions they catalyze. This study describes transient and steady-state kinetic analyses of two flavin amine oxidases, mouse polyamine oxidase (PAO) and human lysine …
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A Pharmacologic Study of Anticholinergic and Monoamine Oxidase Inhibitor Drugs in Dogs and Swine
Made available in DSpace on 2014-12-05T22:04:00Z (GMT). No. of bitstreams: 1 6100150.pdf: 4473299 bytes, checksum: bee3c7912623d19262106e6d53807649 (MD5) Previous issue date: 1960
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Mechanistic Studies on the Monoamine Oxidase B Catalyzed Oxidation of 1,4-Disubstituted Tetrahydropyridine Derivatives
The flavin-containing monoamine oxidases (MAO) A and B catalyze the oxidative deamination of primary and secondary amines. The overall process involves a two electron oxidation of the amine to the iminium with concomitantreduction of the flavin. Based on extensive studies with a variety of chemical …
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Synthesis and biological evaluation of novel MPTP analogs as potential monoamine oxidase B inhibitors
… the only known cyclic tertiary amines with good monoamine oxidase substrate properties. In addition to its substrate properties, MPTP is a weak mechanism-based inactivator of monoamine oxidase-B (MAO-B). In an attempt to exploit the special interactions between this cyclic tertiary allylamine and …
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Studies on the monoamine oxidase substrate/inactivator properties of piperidine analogs of the neurotoxin MPTP
The unexpected monoamine oxidase (MAO) substrate properties of 1-cyclopropyl-4-substituted-1 ,2,3,6-tetrahydropyridines have been interpreted in terms of partitioning of these tertiary cyclic allylamines between substrate turnover and ring opening inactivation processes. To evaluate further this …
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Investigation of FAD Chemical Models to Study the Monoamine Oxidase Catalyzed Oxidation of Cyclic Tertiary-Allylamines
… approach to investigate the mechanism of the monoamine oxidase (MAO) catalyzed oxidation of the cyclic tertiary allylamine 1-methyl-4-(2-methyl-1H-pyrrol-2-yl)-1,2,3,6-tetrahydropyridine (TMMP), which is a close analog of the parkinsonian-inducing designer drug …
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Synthesis and mechanistic studies on the monoamine oxidase (MAO) catalyzed oxidation of 1,4-disubstituted-1,2,3,6-tetrahydropyridines
… in a reaction catalyzed by the flavoenzyme monoamine oxidase B (MAO-B) to form the corresponding dihydropyridinium (MPDP+) subsequently pyridinium (MPP+) metabolites. As part of our ongoing studies to characterize the structural features responsible for this unexpected biotransformation, we …
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Quantitative structure activity relationships of monoamine oxidase catalyzed oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogs
… oxidation catalyzed by monoamine oxidases A and B were performed to elucidate active site substrate conformation and oxidation mechanisms. Plotting experimental kinetic activity against molecular properties obtained by experiment and by computational chemistry methods …
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Development of New N-Cyclopropyl Based Electron Transfer Probes for Cytochrome P-450 and Monoamine Oxidase Catalyzed Reactions
… been used as probes to study the mechanism of monoamine oxidase (MAO) and cytochrome P-450 (cP-450). A photochemical model study of benzophenone triplet (3BP) with the MAO-B substrate 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and two of its derivatives, …
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Potential Prodrugs of the Neuronal Nitric Oxide Synthase and Monoamine Oxidase Inhibitor 7-Nitroindazole and Structurally Related Compounds
… form of nitric oxide synthase (nNOS) and monoamine oxidase B (MAO-B), have been linked to neurodegenerative pathways leading to PD. Several MAO-B and nNOS inhibitors have been evaluated for their neuroprotective properties in the mouse model of neurodegeneration which employs the …
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The monoamine oxidase A gene as a potential moderator of the relationship between parental rearing and symptoms of borderline personality disorder in female undergraduates
… with genetic vulnerabilities, such as the Monoamine Oxidase A gene (MAOA). The present study pursued this line of investigation. Three variants of the MAOA gene were focused on. The highly active variant MAOA-H has been found in significantly higher rates among patients with Borderline …
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The Investigation of the Active Sites of Monoamine Oxidase (MAO) A and B and the Study of MAO-A Mediated Neurotoxicity Using 4-Substituted Tetrahydropyridines
The mitochondrial membrane bound flavoenzymes monoamine oxidase A and B (MAO-A and MAO-B) catalyze the a-carbon oxidation of a variety of amines including neurotransmitters such as dopamine and serotonin. Although the primary structures of these enzymes have been established from the corresponding …
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Effects of Norharmane and Nicotine on the Conditioned Place Preference of Mice
… to this, other tobacco constituents, such as the monoamine oxidase inhibitor norharmane which is found in tobacco leaf and smoke, may be responsible for tobacco addiction by potentiating the rewarding properties of nicotine. Several studies have attempted to observe this phenomenon, however, …
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Production of novel amine oxidases from microorganisms
… the over-expression of an industrially important monoamine oxidase was attempted using different expression systems, both homologous and heterologous, and the optimum conditions for the industrial production were established. Amine oxidases exhibit stereoselectivity, and, therefore, can …
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