Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Monkeypox"”.
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DNA comparisons of the two orthopoxviruses monkeypox and variola
… an animal poxvirus. The most likely candidate is Monkeypox, which can produce human infection clinically resembling smallpox. The work in this thesis is the beginning of a detailed comparison of the DNA of Variola and Monkeypox. A 15.3kb section of the Variola genome was compared with a …
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Molecular and evolutionary analysis of a gene conserved in most Orthopoxviruses
Evidence is presented to show that variola and monkeypox viruses evolved independently from a common ancestor. An open reading frame (ORF), potentially coding for a protein of 341 amino acid residues, was found to be conserved in two strains of variola virus (Harvey and Somalia), but degenerate in …
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Spillover Modelling and Dynamics in Multi-Host Pathogens Transmission
… epizootic contexts. One typical example is the monkeypox. In this research, by delineating host roles and examining transmission dynamics of monkeypox, we can effectively assess the risk of spillover events and inform mitigation and control strategies. We start with a foundational framework that …
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Intraspecies typing of orthopoxviruses
… the viral DNA from a number of isolates of monkeypox was analysed. One of these isolates was the first to be made from a wild caught animal (a squirrel) and the question was whether this isolate could be identified with isolates made from humans who had become infected in the same area of …
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Regulatory Reliance and Post-Marketing Surveillance Systems for Safe and Accelerated Introduction of New Medical Products in Low- and Middle-Income Countries
… diseases outbreaks like Ebola, COVID-19, and Monkeypox has further highlighted the need for regulatory preparedness for health emergencies. Well-resourced countries have developed expedited regulatory pathways for such situations, while LMICs are not as prepared. They lack models for adopting …
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Contribution Of Non-Classical Antigen Presentation To Cd4+ T Cells During Orthopoxvirus Infection
… of mousepox and a close relative of smallpox and monkeypox. First, we determined that whole poxvirions are refractory to processing via the classical exogenous pathway and that use of this pathway alone does not lead to a protective CD4+ T cell response. In the course of this work we also …
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DISSECTION OF HOST-VIRUS INTERACTIONS IN THE HUMAN CENTRAL NERVOUS SYSTEM
… neurotropism of Herpes simplex virus-1 (HSV-1), Monkeypox virus (MPXV), Varicella zoster virus (VZV) and Influenza A viruses (IAV). Our comparative virology approach demonstrated a susceptibility and permissiveness to herpesvirus infection, while in contrast neurons did not show any productive …
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MPOX 2022: Strategic Management During a Public Health Emergency
… organization to learn and adapt. Mpox (formerly monkeypox) is the most recent infectious disease PHE. There is a research opportunity, using a case study design, to describe the key characteristics of the DHHS mpox response, to identify facilitators and barriers to strategic management, and to …
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Intrinsic Control Strategies for Herpesvirus-based Vaccine Vectors
… target zoonotic diseases such as Ebola and human monkeypox, through eliciting a highly immunogenic response. We are investigating strategies to attenuate the virus and control its ability to replicate and persist, while maintaining its ability to elicit protective immune responses. In this project …
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Interactions of viral and cellular Tumour Necrosis Factor Receptor molecules
… poxviral TNFRs from Variola (Smallpox) (VAR) and Monkeypox (MPV) were synthesised and cloned as CFP/YFP and MycHis expression plasmids. Using multi-colour flow cytometry we have shown that, like the MYXT2 vTNFR, VARG4R and MPVJ2R TNFRs are potent intracellular inhibitors of TNFR1-induced cell …
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TRIM5α is a poxvirus restriction factor: viral evasion strategies and a pathway to antivirals
… camelpox virus (CMLV), elephantpox virus, monkeypox virus (MPXV) clades I and II and variola virus (VARV), were shown to co-precipitate and degrade TRIM5α outwith infection. A hypothesis to explain VACV-mediated TRIM5α degradation was that TRIM5α is an anti-VACV restriction factor, and …
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Method development in chemical and biological selection platforms Part one: Reaction mining: A platform for the discovery of novel chemical reactivity Part two: Synthetic platforms for the characterization and targeting of viral RNA-capping enzymes
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2026-05-01
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INNOVATIVE SYSTEMS FOR THE MITIGATION OF RISKS: CATALYSTS AND SMART MATERIALS FOR DETECTION AND DECONTAMINATION OF HAZARDOUS CHEMICAL, BIOLOGICAL AND EXPLOSIVE SUBSTANCES
… (RNA virus), Herpes simplex (DNA virus), and Monkeypox (DNA virus) after 2 min. This drastic biocidal action is therefore attributable to the synergistic effect between the strong Brønsted acidity of the resins and the oxidising capacity due to the presence of H2O2 and in-situ formed …