Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Molecular therapeutics"”.
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Development of peptide inhibitors as molecular therapeutics against tandem-repeat proteins
… their globular counterparts. TR proteins act as molecular scaffolds that facilitate protein-protein interactions (PPIs) in diverse biological contexts. In disease pathologies such as cancers, misfolded, mutated or deregulated TR function is often the cause. However, targeting tandem-repeat …
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Identification and Characterization of a Selective Inhibitor of the PIM-1 Kinase
… function and as a template for the design of molecular therapeutics for diseases in which PIM-1 kinase activity is dysregulated.</p> <p>Using phage display techniques we identified the peptide, HGVKKRPHNPYG, as a probable pseudosubstrate of the PIM-1 kinase with inhibitory activity in the low …
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Engineering developable miniprotein ligand scaffolds
Binding ligands empower molecular therapeutics and diagnostics, yet discovery of protein ligands is hindered by the vast, sparse, and rugged sequence-function fitness landscape. Protein scaffolds, characterized by a conserved framework to support an engineered variable active site, have proven …
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GSK-3 Inhibition: A Novel Approach to Sensitization of Chemo-resistant Pancreatic Cancer Cells
… Many studies have attributed resistance to therapeutics of pancreatic cancer to activity of the transcription factor nuclear factor kappa B (NF-kB). NF-kB is regulated by the serine/threonine kinase glycogen synthase kinase-3 (GSK-3). GSK-3 is a key mediator of pathways such as insulin, wnt, …
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Design strategies and application of stimuli-responsive nanoparticles for cancer diagnosis and therapy
… However, nonspecific distribution of these small molecular therapeutics has adverse side effects reducing the quality of life. Therefore, in the past few decades, massive interest and investment have been given in cancer nanomedicine with the hope to reduce drug-associated toxicity by targeting …
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Computationally-guided inference of cis-regulatory codes in metazoans
… aid the development of specific and effective molecular therapeutics. Towards this goal, this thesis focuses on the computational inference of the cis-regulatory codes (combinations of TF binding site motifs) that drive the precise spatio-temporal expression of different sets of genes. The …