Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Molecular sensors"”.
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Molecular Sensors at the Nanoscale: Modeling and Technology
L'abstract è presente nell'allegato / the abstract is in the attachment
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Fluorescent-Labeled Estrogen Receptors: Molecular Sensors of Receptor Structure and Function
… domain, we have created out of the ER a molecular sensor through which we can probe directly the conformational state of the receptor with high sensitivity. Thus, fluorophore-labeled ERs provide tools for studying receptor structure and function that nicely complement x-ray …
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Molecular fluorescent reporters for force and smart surfaces for sensing cell-surface interaction
Molecular sensors are powerful because they make it possible to adapt the measurement to the sample instead of a sample to an instrument. Many reporter are available for measuring the chemical properties of a sample, but no purpose-built molecular sensors exist to report a sample's mechanical …
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Towards brain-wide noninvasive molecular imaging
… underlies brain activity, yet studying these molecular events in living whole organisms remains a challenge. Magnetic resonance imaging (MRI) is the most promising imaging modality for development of molecular signaling sensors with deeper tissue penetration than optical imaging, and better …
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Genetically engineered sensors for non-invasive molecular imaging using MRI
… and temporal resolution. However, the range of molecular phenomena currently accessible to MRI is limited by a lack of suitable molecular sensors. Most efforts to create such sensors have focused on synthetic contrast agents, whose complicated structures make them difficult to engineer, …
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LisNRs : a novel class of liposomal contrast agents for molecular MRI
Biological systems depend on numerous molecular messengers that transduce information across large distances. Understanding the spatial and temporal dynamics of molecular signaling networks is crucial for the construction of systems- and organism-level models of biological function. Molecular …
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Lanthanide complexes of phthalimide and phthalamate containing ligands: synthesis, photophysical properties and their potential applications
Molecular sensors and switches have made important contributions to biomedical devices and molecular computational operations. There are numerous molecular designs using a fluorophore linked through a spacer group to a receptor(s), with a wide dynamic range, directional precision, target …
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Nuclear magnetic resonance readable sensors
… of disease. We describe here the development of molecular sensors which can be read by magnetic resonance (MR) relaxometry. MR is an advantageous bio-sensor readout because it can be determined from opaque samples and through intervening layers of matter. Wash steps can therefore be avoided in in …
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Leveraging Metal Complexes for Optical Read-out of Magnetic Fields
… development of highly sensitive and versatile molecular sensors. This thesis investigates the design of metal complexes tailored for magnetic field read-out through light–matter interactions, focusing on two strategies. The first section explores magnetochiral dichroism (MChD), an optical …
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Biomimetic sensor for in-vivo applications
… development of sensitive specific devices (e.g., molecular sensors) for the detection, diagnosis and monitoring of diseases, drug discovery, environmental detection of pollutants and/or biological agents has been an active area of research. A molecular sensor is a biomolecule or biomimetic …
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Novel Luminescent Lanthanide Complexes as Reporters of Cellular Oxidative Stress
… in order to develop ROS-responsive luminescent molecular sensors. A synthetic strategy involving the synthesis of an intermediate ligand was applied to the asymmetrically functionalisation of the cyclen ring. The intermediate ligand was called “the generic ligand” since it possesses a generic …
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Noninvasive Neuromodulation via Ultrasonic Activation of Endogenous and Exogenous Ion Channels
… channels, including TRPV1 and TRPM2, are the key molecular sensors for ultrasound neuromodulation. Chemical blocker and genetic knockdown of the TRPM2 and TRPV1 in the hypothalamus significantly suppressed the ultrasound-induced torpor effect. Overexpression of TRPM2 and TRPV1 in HEK293 cells …
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USING CONJUGATED POLYMERS AS BIOLOGICAL SENSOR BASED ON FLUORESCENCE RESONANCE ENERGY TRANSFER
… in this dissertation are to design novel molecular sensors based on fluorescence resonance energy transfer (FRET) between fluorophore (donor) and polydiacetylene (PDA, acceptor) for selective detection of biomolecules in solution. The work described in this dissertation is divided into …
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DNA as a functional molecule for control of nanomaterial morphology and for biosensing
… player for self-assembly, material synthesis and molecular sensors. Given the ease of synthesis and modification, precise control over sequence and specificity in base pairing, the number of studies with DNA as a functional molecule have increased. Intrigued by the inherent chemical functionality …