Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 208 for “"Molecular recognition"”.
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Molecular recognition in plant immunity
… these are predominantly based on genetic and molecular studies. Biochemical investigations into R-protein function have been hampered by difficulties obtaining sufficient yields of material. When suitable material has been identified, biochemical studies have been used to complement …
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Molecular Recognition of Nucleic Acids
Part II presents the design and attempted synthesis of several novel nucleosides that were intended to hydrogen bond to Watson-Crick base pairs in the major groove of DNA. The geometry of the connection of these heterocycles to the ribose backbone was designed to be isomorphous with the T$\cdot$AT …
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Investigations of molecular recognition processes
… structure-activity relationships, chiral recognition models were proposed. For one class of CSP, the chiral recognition model has been further supported using spectroscopic and chromatographic evidence. Two $\alpha$-amino phosphonate derived CSPs were prepared and their ability to separate …
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Molecular recognition of aberrant translation
… thesis, which is focused on understanding the molecular principles that determine accurate recognition of aberrantly slow ribosomes. To address this, we developed a novel flow cytometry-based assay to visualize terminal ribosome stalling at single cell resolution in mammalian cells. Using the …
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Molecular recognition of adenosine derivatives
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1994.
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New scaffolds for molecular recognition
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1995.
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MOLECULAR RECOGNITION OF THYROGLOBULIN BY SORTILIN
… for its iodinated forms. However, the molecular basis of this interaction has remained elusive. Here, we elucidate the mechanisms of TG recognition by sortilin using an integrated approach combining cryo-electron microscopy, crosslinking mass spectrometry, biophysical characterisation, …
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Molecular Recognition At Dna Damage Sites
… this dissertation is the BRCA1-RAP80 ubiquitin recognition complex, which is composed of five core constituents (RAP80, Abraxas, MERIT40, BRCC45, and BRCC36) and targets BRCA1 to the chromatin flanking DNA damage sites. Although this complex is required for BRCA1 chromatin localization, its …
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Structure and molecular recognition in riboswitches
Riboswitches are cis-acting gene regulatory RNAs, which function without involvement of proteins. They have been implicated as drug targets and are attractive systems for the study of RNA-ligand binding and RNA folding. The purine riboswitch was used as a model system for RNA-ligand docking. …
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Molecular recognition of nucleic acid components
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1992.
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Molecular recognition of chlorine-doped polypyrrole
… using phage display found a surface specific recognition peptide (T59) that was made bivalent by altering the C-terminus with an integrin binding epitope. The bivalency of the modified T59 peptide was exploited to tether phenochromocytoma (PC12) cells to the surface of PPyCl. Furthermore the …
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Gel phase transition and molecular recognition
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Physics, 1997.
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Molecular recognition through rational and combinatorial synthesis
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1996.
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Molecular recognition using nanotube-adsorbed polymer complexes
… we also explored the concept of creating molecular recognition sites using polymer-SWCNT complexes. Molecular recognition is central to the design of therapeutics, chemical catalysis and sensor platforms, with the most common mechanisms involving biological structures such as antibodies[l] …
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Ureas in molecular recognition : complexation and encapsulation
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1996.
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Examination of Molecular Recognition in Protein-Ligand Interactions
… driving forces and principles which govern molecular recognition and molecular design. A prospective study coupled computational predictions with experimental validation resulted in the discovery of first-in-class inhibitors targeting a signal transduction module important for bacterial …
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The impact of protein fluctuations on molecular recognition
The effect of protein fluctuations on molecular recognition is poorly understood. Prediction of useful properties such as binding affinity using rigid structures has produced sporadic success. Although attempts have been made to model the effect of\r\nconformational fluctuations, capturing the …
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Molecular Recognition in Host-Guest Ionophore-Siderophore Assemblies
… work examines the characterization of supramolecular assemblies and, more specifically, host-guest complexes involved in molecular recognition events. The supramolecular assemblies studied take root from metal ion delivery in biological uptake pathways, specifically the delivery of iron to …
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SYNTHESIS OF CHROMO FLUOROGENIC SENSORS FOR MOLECULAR RECOGNITION
… to recognize a substrate and to transform this recognition event into a detectable signal or into a real reaction. What we expect is a change of the optical properties of these compounds, for instance expressed by a colour switching or a fluorescence alteration both in solution and on the solid …
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Protein Monolayers: Molecular Recognition, Stability and Imaging Studies
Scanning probe microscopies, particularly atomic force microscopy and scanning tunneling microscopy, offer structural biologists new and powerful methods for understanding biointerfacial systems. Both STM and AFM provide information about the structure of protein monolayers and these techniques, …
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