Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Molecular prosthetics"”.
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Development of second-generation amphotericin B molecular prosthetics for enhanced therapeutic efficacy in cystic fibrosis
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-12-01
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Amphotericin B ion channels restore cystic fibrosis airway surface physiology
… arm or leg, small molecule surrogates acting as prosthetics on the molecular scale could replace protein functions that are either dysfunctional or absent in humans. These ‘molecular prosthetics’ could build upon and interface with the existing architecture and residual function of the organism …
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From yeast to animals: A small molecule restores iron mobilization, absorption and hemoglobinization
In the classic paradigm of pharmacology, small molecules bind to and modulate dysfunctional or overactive proteins. However, in cases where a protein is missing, this strategy is no longer viable. Disorders of iron metabolism are the most prevalent genetic diseases worldwide and currently, there …
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Small molecule channels increase anion secretion and host defenses in cystic fibrosis airway epithelia: mechanistic studies and initial clinical translation
Cystic fibrosis (CF) is caused by more than 1,900 loss-of-function mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel. Loss of CFTR-mediated HCO3- and Cl- secretion to the airway surface liquid (ASL) compromises airway host defenses in people …
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Restored iron transport by a small molecule promotes absorption and hemoglobinization: discovery, development, and mechanistic studies
Traditional approaches in the pharmaceutical industry center around the development of small molecule therapeutics that bind to and inhibit overactive protein function. This has been transformational in the treatment of diseases resulting from an excess of protein function, however, thousands of …