Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Molecular prosthetic"”.
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Elucidation of the mycosamine dependent sterol binding and antifungal activities of amphotericin B
… of AmB or harness its potential to act as a molecular prosthetic to treat diseases that arise from a lack of protein function would benefit from an atomistic understanding of the mechanism of action. To elucidate this poorly understood mechanism, we developed a strategy focused upon the …
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Minimizing higher-order aggregation maximizes iron mobilization by small molecules
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-08-01
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Mechanisms underlying polyene macrolide mediated rescue of growth in ion channel deficient yeast
… mimic of a missing protein ion channel, a.k.a. molecular prosthetic is sufficient to restore physiology in a protein-deficient model organism. We demonstrated that AmB both vigorously and sustainably restored physiology in K+ transporter deficient yeast (trk1Δtrk2Δ). Furthermore, we showed that …
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Restored iron transport by a small molecule promotes absorption and hemoglobinization: discovery, development, and mechanistic studies
Traditional approaches in the pharmaceutical industry center around the development of small molecule therapeutics that bind to and inhibit overactive protein function. This has been transformational in the treatment of diseases resulting from an excess of protein function, however, thousands of …