Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 46 for “"Molecular probes"”.
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Investigating and Reprogramming RNA Folding with Molecular Probes
Ribonucleic acid (RNA) performs versatile, essential functions in all known organisms and viruses. These functions require the RNA to fold into specific secondary and tertiary structures, and in many cases to switch among multiple structural states. Predicting and experimentally determining RNA …
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New Molecular Probes of Astronomical Sources (Interstellar Sources, Comets)
… for refining the knowledge of astronomical molecular sources. The primary project involved HCO in interstellar molecular clouds. The observational results include the verification of the identity of interstellar HCO, the confirmation of the C('+)-HCO correlation first suggested by Snyder, …
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Multifunctional Chemical Cross-linkers for Drug Carriers and Molecular Probes
Bioconjugates are an indispensable tool for molecular biology as well as an established modality for biomedical imaging and drug delivery. Broadly, bioconjugation is the use of a chemical cross-linker to covalently attach non-natural reporters, chemical handles, drug cargo, or targeting ligands to …
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Detection of Biologically Relevant Anions by Fluorescence and NIR Molecular Probes
… detection of biologically relevant anions using molecular probes. The first part has demonstrated that hydroethidine is oxidized to ethidium under the pro-oxidative effect of flavonols under physiological conditions and is a sensitive fluorescent probe for rapid quantification of the superoxide …
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DEVELOPMENT OF MOLECULAR PROBES ACTING ON aSYN/TUBULIN AND TAU/TUBULIN INTERACTION
… of this PhD is the development of peptide based molecular probes able to modulate the Tau and α-Synuclein interaction with Tubulin. A library of peptides, both native and mutated sequences of αSyn, were synthesized and were used as molecular ‘tools’ for the conduction of in vitro experiments. The …
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Frequency domain fluorescent molecular tomography and molecular probes for small animal imaging
… we have developed a frequency domain fluorescent molecular tomographic system based on the heterodyne technique using a single source and detector pair for small animal imaging. In our system, the intensity of laser source is modulated to produce a diffuse photon density wave in the tissue. The …
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The Synthesis and Evaluation of Non-Targeted Near-Infrared Heptamethine Molecular Probes
Detecting and quantifying biomolecules is an important tool in biological research. Ideal dyes have to have a number of characteristics i.e. low toxicity and limited autofluorescence. The properties of near infrared dyes make these ideal for cell and tissue imaging. The work within this thesis …
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Molecular Probes for Biologically Important Molecules: A Study of Thiourea, Hydroxyl radical, Peroxynitrite and Hypochlorous acid
Numerous chemical species are important to the health of biological systems. Some species can be beneficial at low doses and harmful at high doses. Other species are highly reactive and trigger serious cell damage. Improved methods to detect the presence and activity of such species are needed. In …
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Molecular Characterization of the Opioid Receptors: Design, Development, and Preclinical Evaluation of Salvinorin A-Based Molecular Probes.
… the development of analogues as essential molecular probes to elucidate the structure-activity-relationship of the salvinorin-class.</p> <p>In this study, we expand the current field of salvinorin chemistry through the design, development, and preclinical evaluation of a series of …
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Leveraging Bioorthogonal Chemistry for Hyperpolarized Magnetic Resonance and Metal Uncaging
… are typically less than a minute for many common molecular probes. Bioorthogonal handles such as azides and tetrazines are shown to be a viable, highly generalized approach to overcome these lifetime limitations in a variety of molecular probes. Additionally, in the field of inorganic chemistry, …
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I. Molecular Probes for the Progesterone Receptor. II. Design and Synthesis of a Rigidly Constrained Peptidomimetic as a Potential Beta-Turn Mimic. III. Isolation and Characterization of Novel Ion Channel Modulators From Commercial Phenol Red Preparations
Chemical probes for steroid receptors have proven useful in providing molecular details about important hormone-receptor interactions. $16\alpha,17\alpha$- ((R)-1$\sp\prime$-(4-Azidophenyl)-ethylidenedioxy) pregn-4-ene-3,20-dione (12) was prepared in high specific activity tritium-labeled form (20 …
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Genetic selection of cyclic peptide G-quadruplex ligands
Molecular probes are often at the forefront of chemical attempts to investigate biological structures for their function. Indeed, molecular probes that bind the G-quadruplex (G4) nucleic acid structure have been instrumental in demonstrating the existence and biological importance of these …
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The synthesis and evaluation of estrogenic probes for in vitro and in vivo studies
… twenty years had a strong interest in developing molecular probes for steroid hormone receptors, and in particular, the estrogen receptor (ER), in order to further elucidate its structure and function, and to aid in the clinical evaluation and treatment of patients suffering from breast cancer. …
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Characterization and Implications of Surface Hydrophobicity in Nanoparticle Fate and Transport
… selected NPs, as characterized by adsorption of molecular probes (i.e. organic dye and naphthalene), was consistent with the macroscopic contact angle measurements and octanol-water distribution coefficients. The in-situ adsorption of these molecular probes offers the most solid grounds for …
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Design of optical characteristics of ceria nanoparticles for applications including gas sensing and up-conversion
… and are larger than some of the fluorescent molecular probes currently used to measure DO. The KSV measured between 25-50oC is found to be significantly less temperature dependent as compared to the constants of commercially-available DO molecular probes. In the second application, …
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Synthesis and Spectroscopic Studies of Substituted Pyrrolocytidines
… of modified nucleosides for potential use as molecular probes in nucleic acid chemistry. These heterocyclic base surrogates that are capable of canonical base pairing have use in the study of nucleic acid conformation, as reporters of the state of hybridization.[1] The synthesis of a …
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Design, synthesis, and biochemical evaluation of three types of hexestrol-based probes for estrogen receptor: Fluorine-18 radiopharmaceuticals, bivalent ligands and diazirine photoaffinity reagents
… drug design for human breast carcinoma. Molecular probes, such as fluorine-18 radiopharmaceuticals, bivalent ligands, and affinity labels, provide information toward a better understanding of ER localization, structure, and function. We have prepared two fluorinated analogs of …
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Integrated and scalable molecular brain mapping
… selectively expedites transport of molecular probes into the tissue without damaging it. SWITCH synchronizes the labeling reaction to achieve consistent and uniform labeling. These technologies are demonstrated by successfully visualizing several molecular markers in adult mouse …
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Applications of Sortase A from Staphylococcus aureus
… method for attaching a wide range of molecular probes to biological molecules, such as proteins and DNA. This method does not require any toxic reagents or harsh conditions to achieve high level of labelling, and the product could be easily isolated from the reaction mixture. This new …
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Biopolymer-mediated analyte detection via photoluminescence modulation of single-walled carbon nanotubes
… demonstrating the potential of nanotube-based molecular probes and biosensors. The work culminates in several major findings in optical sensing. We show that a nanotube-ds(GT)15 DNA complex can detect genotoxic analytes by solvatochromism, and measure this from within live cells and tissues in …
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