Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"Molecular pathway"”.
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Molecular pathway analysis and therapeutics development in post-traumatic osteoarthritis
… approach was employed to determine the pathways that are activated upon cytokine challenge of adult human chondrocytes. We identified key regulatory kinases, p38, JNKI/2, ERKI/2, ERK5, JAK2, and STAT3 that were upregulated in phosphorylation as a result of inflammatory cytokine …
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A Novel Molecular Pathway Involving GPR10, REST, and PRICKLE1 in the Pathogenesis of Uterine Leiomyoma
… UL. Remarkably, very little is known about the molecular pathogenesis of UL. Environmental estrogen exposure is one of the most recognized risk factors associated with the development of UL tumors. At the cellular level, extensive evidence has linked the cell proliferation, survival and growth …
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Chronobiological plasticity in Honeybee and its association with differences in the organization of the molecular pathway between central and peripheral clocks: the brain and flight muscle tissues.
Circadian rhythms govern the behavior, physiology, and metabolism of living organisms, enabling them to anticipate changes of environmental conditions. Within Insects, in honey bee s colonies an ontogeny in circadian rhythms of behavior was suggested to be related to an age- based division of …
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Endocyclic Nucleophilic Methyl Transfer
… Since existence of an intra- molecular pathway would represent the first example of an endo- cyclic methyl transfer, kinetic and double-label crossing experiments were used to determine the molecularity of these rearrangements. Methyl 4-(dimethylamino)butane-1-sulfonate, at …
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Role of the immunoglobulin superfamily member Basigin in sensory neuron dendrite morphogenesis in Drosophila
… suggesting that they function in the same molecular pathway in regulating dendrite development. Taken together, data presented in this thesis support a model in which interaction between Basigin on the surfaces of neurons and epithelial cells regulate the underlying cytoskeleton within …
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The role of ErbB inhibitors in promoting nerve regeneration in a mouse model of nerve injury
… following nerve repair. For elucidation of the molecular pathway that could be promoting nerve regeneration, in vivo neurite growth assays interestingly demonstrated that gefitinib, more than lapatinib rescued the inhibitory effects by chondroitin sulfate proteoglycan on neurite growth. …
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Mechanisms Underlying The Sensitivity and Resistance of Gastric Cancer Cells to Met Inhibitors
… a therapeutic target in gastric cancer, but the molecular mechanisms underlying sensitivity and resistance to MET inhibitors are still not well understood. Using whole-genome mRNA expression profiling, we identified autophagy as a top molecular pathway that was activated by the MET inhibitor …
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Genetic analysis of cGMP-dependent chemosensory signal transduction pathways in the detection of bacterial metabolites by C. elegans
… genetic elucidation of a Caenorhabditis elegans molecular pathway that transduces the presence of pathogens to activate the transcription of a neuroendocrine ligand. Previously, our group has showed that secondary metabolites produced by the pathogen P. aeruginosa cause an expression pattern …
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Novel Molecules that Regulate Bone Formation and Bone Resorption
… from oxidative stress induced apoptosis via a molecular pathway that involves regulation of reactive oxygen species production, cardiolipin oxidation, caspase activity, iron-sulfur cluster formation, and manganese superoxide dismutase activity. We found that DOR is an important regulator of …
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Biochemical and Functional Characterization of Novel RNA-binding Proteins Interacting with SMN in Motor Neuron-derived Cells
… may help shed light on the non-canonical molecular pathway(s) involving SMN and RBPs in motor neurons and underscores the possible therapeutic benefits of targeting these RBPs in the treatment of SMA.
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Phagocytosis promotes programmed cell death and is controlled by Rac signaling pathway in C. elegans
… control the execution of cell death and define a molecular pathway for cell death conserved in humans. Seven genes control the engulfment of cell deaths and define two partially redundant pathways: ced-1, ced-6, and ced-7 in one pathway and ced-2, ced-5, ced-10, and ced-12 in the other. ced-3 …
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Experiments concerning the mechanism of cytokinesis in Caenorhabditis elegans embryos
… elements. I then wanted to identify the molecular pathway responsible for cytokinesis furrow positioning in response to the microtubule asters. To this end, I performed an RNAi screen, which identified a role for LET-99 in cytokinesis: LET-99 appeared to be required for aster-positioned …
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Functional studies of <i>Ci-Gsx</i> gene in the developing central nervous system of <i>Ciona intestinalis</i>
… despite its simplicity, possesses functional and molecular similarities to vertebrate eye, thus representing a valuable tool to study the basic mechanisms of eye development. The aim of my PhD work has been the investigation of Ci-gsx function in the early specification of photoreceptor cells in …
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The Role of Von Hippel-Lindau Protein in the Glomerulus
… disease in an animal model and suggest novel molecular pathways for intervention in this disease. In addition, we demonstrate a key role for VHL-HIF-Cxcr4 molecular pathway for the integrity of the glomerular barrier.
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Control of Skeletal Muscle Fiber Types by Calcium Signaling Pathways
… and other calcium-regulated signaling pathways in the control of myofiber specialization. By analyzing two fiber type-specific enhancers, I was able to demonstrate that there are functional NFAT (nuclear factor of activated T cells) and MEF2 (myocyte-specific enhancer factor 2) binding …
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A New Tumor Suppressor Gene Candidate Regulated By The Non-Coding Rna Pca3 In Human Prostate Cancer
… and may provide important insights into the molecular mechanisms underlining the tumorigenesis process of prostate cancer. PCA3, is considered the most specific prostate cancer biomarker, however its biological role, until now, remained unknown. PCA3 is a long non-coding RNA (ncRNA) expressed …
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The photocatalytic degradation of phenolic compounds
… This study aimed to elucidate the primary molecular events by HPLC analysis of the initial products of degradation in water or aqueous acetonitrile. <br></br><br></br>The position of substituents relative to the hydroxyl group were found to influence the reaction rate and also primary …
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NEUROPROTECTIVE STUDIES ON THE MPTP AND SOD1 MOUSE MODELS OF NEURODEGENERATIVE DISEASES
… degenerative process or a discrete cellular molecular pathway may be ineffective in the treatment of these multifaceted disorders. Rather, potential therapeutics with a multi-target approach may be required to successfully and effectively control disease progression. Recent advances in …
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Regulation of cytotoxic drug-induced apoptosis by death receptor 5 in human colon cancer cells
… which needs to be overcome. Understanding the molecular pathway of 5-FU-induced apoptosis will help designing more effective cancer treatments. Chemotherapeutic drugs such as 5-FU are thought to trigger cell death via the intrinsic apoptosis pathway which involves caspase-9 activation as one of …
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The Role of TBX3 In Early Breast Cancer Progression
… expression by IHC in the invasive carcinoma. Pathway analysis of transcriptomics data revealed altered expression of several proteases and their inhibitors, consistent with the ability of tumor cells to degrade basement membrane. These findings strongly suggest the involvement of TBX3 in the …
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