Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 35 for “"Molecular pathogenesis"”.
-
Molecular Pathogenesis of MALT lymphoma
… can be cured by antibiotics. To understand the molecular mechanism of MALT lymphoma with and without chromosome translocation, 24 cases (15 translocation-positive and 9 translocation-negative) of MALT lymphomas together with 7 follicular lymphomas and 7 mantle cell lymphomas were analysed by …
-
The molecular pathogenesis of myeloproliferative neoplasms
… of one or more cells of the myeloid lineage. The molecular<br/>investigation of MPN was revolutionized in 2005 by the finding that approximately 95% of cases with<br/>polycythaemia vera (PV) and 50-60% of cases of essential thrombocythaemia (ET) and primary<br/>myelofibrosis (PMF) are …
-
Molecular Pathogenesis of Spinocerebellar Ataxia type 10
… The present study is focusing on elucidating a molecular pathogenesis of this unique inherited disease. In this study, we demonstrate normally transcribed ATTCT-repeat forms a lengthy AUUCU pre-mRNA molecule in SCA10 cells, after being completely spliced out. We identify the specific interaction …
-
Molecular Pathogenesis of Spinocerebellar Ataxia type 10
… The present study focused on elucidating a molecular pathogenesis of this unique inherited disease. In this study, we demonstrated normally transcribed ATTCT-repeats form a lengthy AUUCU pre-mRNA molecule in SCA10 cells, after being completely spliced out. We identified the specific …
-
Molecular pathogenesis of Helicobacter hepaticus induced liver disease
… the histopathological diagnosis, and suggested molecular targets for the monitoring and intervention of disease progression prior to the onset of hepatocellular neoplasia. Our laboratory, in collaboration with Professors Suerbaum and Schauer, recently identified a
-
The human myeloproliferative disorders: molecular pathogenesis and clonal heterogeneity
… clinical or histopathological subtype of ET, molecular testing provides an important new tool in the diagnostic armamentarium. Clones homozygous for the JAK2 V617F mutation were identified in female but not male patients with ET, suggesting that gender differences may be important in the …
-
Molecular Pathogenesis of Autism: A Role for Neurexin and Neuroligin
… molecules that have been linked to ASD pathogenesis. I found that three different mouse models for ASDs, the neurexin-1α deletion, the neuroligin-3 (NL3) R451C mutation, and the NL3 R704C mutation all aberrantly alter synaptic transmission. First, I showed that deletion of neurexin-1α in …
-
New insights in the molecular pathogenesis of neurofibromatosis type 1
… when and in what cell type the crucial molecular defect actually occurs has proven to be surprisingly difficult for many NF1-related symptoms. Impeding factors include the large size of the NF1 gene, the presence of several NF1 pseudogenes, the complex interactions between cell types …
-
Aberrant epigenetics in the molecular pathogenesis of human acute myeloid leukemia
… genes from different gene families during the molecular pathogenesis of human AML. Furthermore, the mechanism of promoter methylation mediated transcriptional silencing acts in concert with specific histone modifications which, importantly, can be reversed by treatment with pharmacological …
-
Investigating the molecular pathogenesis of tuberculosis-associated immune reconstitution inflammatory syndrome
… investigate the mechanisms underlying the immunopathogenesis of paradoxical tuberculosis associated immune reconstitution inflammatory syndrome (TB-IRIS). Paradoxical TB-IRIS is an aberrant immune response targeted against Mycobacterium tuberculosis or its residual antigens in patients with …
-
NEW INSIGHTS INTO THE MOLECULAR PATHOGENESIS OF SEVERE FEVER WITH THROMBOCYTOPENIA SYNDROME VIRUS
… regions where the virus is endemic. SFTS virus pathogenesis remains understudied despite it being listed as a Category C priority pathogen by NIAID and considered a priority pathogen by the World Health Organization. Understanding mechanisms by which SFTS virus causes severe disease is a …
-
Molecular Pathogenesis and Development of a Genetically Engineered Vaccine for Type-2 Porcine Circovirus
Porcine circovirus type 2 (PCV2) is the primary causative agent of postweaning multisystemic wasting syndrome (PMWS), whereas the ubiquitous porcine circovirus type 1 (PCV1) is nonpathogenic for pigs. Since its initial detection in a Canadian commercial swine herd in 1991, PMWS has been detected in …
-
Understanding the molecular pathogenesis of HIV-associated Burkitt Lymphoma – the impact of HIV-1 protein Tat on lymphoma driver genes
… function of HIV in BL development. However, the molecular mechanisms underlying this HIV-associated malignancy are not well understood. This study explores the oncogenic potential of HIV-1 protein Tat in BL via its ability to manipulate the expression of c-MYC and activation-induced cytidine …
-
Role of Hypoxia-inducible Factor in Kidney Cancer
… hypoxia, triggers a myriad of alterations within molecular pathways aimed at ensuring sustained viability and functionality of vital organs. The master regulator of the hypoxic response is the heterodimeric HIF transcription factor, composed of an oxygen-labile HIFalpha subunit and a …
-
Deletions in SARS-CoV-2 nsp6 enhance antagonism of type-I interferon signaling
… effort has been made to understand the molecular pathogenesis of SARS-CoV-2. Recent research has identified nonstructural protein 6 (nsp6) as a major contributor to SARS-CoV-2 replication through the formation of replication organelles, antagonism of interferon type I (IFN-I) responses, …
-
The molecular genetic investigation of paediatric liver disease
… in many cases however little is known about the molecular pathogenesis of the disease, an understanding of which may identify specific therapeutic options. The aim of this thesis is to investigate the molecular genetics of rare liver disorders as the first step in advancing the understanding of …
-
Meta-analysis of liver transcriptomic data identifies accurate disease classifiers and disease perturbed networks
… diseases have improved our knowledge of the molecular pathogenesis of liver diseases and produced potential biomarkers. However, these studies typically rely on binary phenotype comparisons (e.g. cancer vs. normal) to identify disease signatures. It is possible that the resulting signatures …
-
Myeloid cells induce neurofibromatosis type 1 aneurysm formation through inflammation and oxidative stress
… death secondary to their rupture. However, the molecular pathogenesis of NF1 aneurysm formation is completely unknown. Utilizing a novel model of Nf1 murine aneurysm formation, we demonstrate that heterozygous inactivation of Nf1 (Nf1+/-) results in enhanced aneurysm formation with myeloid cell …
-
Investigation of the role of IQGAP1 in metastasis
… events that remain poorly understood at the molecular level. Recently, advances in microarray technology have allowed cancer biologists to globally survey metastatic progression and define patterns of gene expression that correlate with progression to a metastatic phenotype. By using such a …
Page 1 of 2