Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"Molecular neuroscience"”.
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Structural insights into the GABAA receptor gating cycle
… play essential modulatory functions, however, a molecular understanding of such impacts is lacking. As a result, the mechanisms of GABA-ergic signalling, in physiologically meaningful environments and time scales, remain among the most important unknowns in molecular neuroscience. To address …
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Spontaneously Regenerative Corticospinal Neurons in Mice
… an intricate and redundant ensemble of molecular signals exerts tight control over midline crossing. The ipsilateral axons represent a consistent anomaly across many species at an evolutionarily ancient midline boundary that is under strict developmental control. To better understand …
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Neuronal filopodia borne along tips and shafts of dendrites comprise two distinct populations as evidenced by differences in structure and dynamics
… interest in the field of cellular and molecular neuroscience. Subsequent studies into their morphogenesis, and into synaptogenesis, brought into the spotlight their putative precursors – the dendritic filopodia. This set off several lines of investigation into filopodial structure and …
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Involvement of kainate glutamate receptors in the modulation of neuronal transmission in brain areas involved in migraine pathophysiology
Migraine pathophysiology is thought to involve activation of the trigeminal fibres which innervate dural structures. The nociceptive inflow from the meninges is relayed to the trigeminocervical complex (TCC), before ascending to higher brain areas, including the thalamus. Glutamate is implicated in …
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Genetic Characterisation of Neurodegenerative disorders
… in this work with the hypothesis that common molecular pathways are involved in these disorders. Multiple common variants of the H1 haplotypes were identified and one common haplotype, H1c, showed preferential association with PSP and AD. A whole-genome association study of PD was also …
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An investigation into the desensitization of neurotransmitter gated ion channels — functional relevance, impact on ganglionic receptor function, and structural insights
The desensitized state of neurotransmitter-gated ion channels (NGICs) remains poorly understand, both in terms of its functional role and its structure. Although the state was historically thought to have limited functional relevance, recent results have demonstrated that the state is indeed likely …
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Intra-Regional Differences in Cerebellar Vulnerability of Spinocerebellar Ataxia Type 1 Mice
… across distinct regions and, if so, what molecular and functional mechanism underlie those differences in mouse models of SCA1. To address this gap in knowledge, I sought to investigate SCA1 pathology across distinct cerebellar regions in a mouse model of SCA1. I hypothesized that SCA1 …
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Behavioural and Metabolic Characterization of NPR-9 and AIB Signaling Dynamics in Caenorhabditis Elegans
Caenorhabditis elegans inhabit heterogeneous environments and are often faced with diverse environmental cues. The nematode must modulate behavioural and physiological mechanisms to avoid aversive environmental conditions while favouring conditions that promote growth. Therefore, organisms must …
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Novel Drug Discovery for Glioblastoma Multiforme Using Brain Tumour Initiating Cells
… represent the first step toward an effective molecularly targeted therapeutic for GBM.
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Regulation of mammalian photoreceptor phosphodiesterase (PDE) by its noncatalytic GAF domains and its two small subunits, gamma and delta
<p>cGMP phosphodiesterase (PDE) is the central effector of visual transduction in retinal rod photoreceptors. The overall goal of this work was to investigate the possible regulatory mechanisms of PDE in mammalian rod photoreceptors by its noncatalytic cGMP binding sites on the PDE catalytic dimer …