Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Molecular networking"”.
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Deciphering the chemistry of host-parasitic plants interactions using the UHPLC-q-TOF-MS and chemometrics
… time-of-flight mass spectrometry and classical molecular networking, it was observed that the metabolic profiles of V. combreticola samples from these two host plants exhibited significant similarities. However, the metabolic profile of V. combreticola was notably distinct from that of these two …
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Assessment of nutraceutical attributes of selected wild edible fruit plants used by Vhavenda people of the Thulamela Local Municipality
… Thus, in this study, we propose the use of molecular networking to unravel the families using the metabolome analysis of two Strychnos species (Strychnos pungens and Strychnos spinosa) and highlight the relevance of molecular networking in exploring the chemotaxonomy of plants. This allows …
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Screening rare filamentous actinobacteria for novel antimycobacterial compounds
… using Global Natural Products Social (GNPS) molecular networking methodology. Molecular networking allowed for the dereplication of known compounds early in the drug discovery process. Strains Amycolatopsis circi S1.3T , Actinomadura strain M2 grown in ISP2 medium and Kribbella speibonae SK5 …
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Extração, caracterização fitoquímica e padronização do extrato das folhas de Passiflora cincinnata para o desenvolvimento de nanoemulsões com potencial hidratante e pró-idade
… were obtained and analyzed by HPLC/MS. A molecular network was generated using the Global Natural Product Social Molecular Networking (GNPS) platform. The antioxidant activity of the 12 extracts was assessed through various tests targeting different stages of the oxidative cascade. For …
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Exploring the molecular diversity and biomedicinal potential of marine invertebrates and South African actinomycetes for tuberculosis drug discovery
… dereplicated using 1H NMR, HR-LCMS with GNPS molecular networking. The extracts were subsequently subjected to an activity-guided isolation process to yield heteronemin from Hyrtios reticulatus extract, and bengamides P and Q from Jaspis splendens extract. A new bengamide derivative was …
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Screening of South African marine filamentous actinobacteria for antitubercular compounds
… product drug discovery in the past. For example, molecular networking can rapidly dereplicate and verify novel compounds, streamlining the pipeline of drug discovery by allowing antibiotic-producing actinobacteria to be investigated more easily as possible drug sources. Microbial diversity has …
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Screening for novel compounds produced by Actinobacteria and Gardnerella vaginalis that impact HIV-1 infection
… and the Global Natural Products Social Molecular Networking (GNPS) database. These strains produced known antimicrobials: Actinomycin D, Valinomycin, Antimycin, Puromycin and Anisomycin. As some commercial antibiotics have been shown to have antiviral activity, we tested the ability of …
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Metagenomic guided isolation of sporoactinomycetes from soil and screening for antimycobacterial activity
… to Global Natural Products Social (GNPS) molecular networking analyses to assess if the compounds produced are known compounds. None of the active actinobacterial strains showed activity against E. coli ATCC 25922, with just two strains (Actinomadura strain 1KK1 on R2A medium and …
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Analysis of Actinobacterial Biodiversity in Marine Sediment from Gericke's Point (South Africa) and Screening of Isolates for Novel Antimycobacterial Compounds
… within the Global Natural Products Social Molecular Networking (GNPS) database. Eighteen (18) strains produced compounds with no matches in the GNPS database indicating these compounds could be novel. One strain produced a potential analogue of abyssomicin L (a rare antibiotic). Overall, …
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Isolation, identification, and characterization of antibiotic-producing microorganisms from soil
… of the active bacterial isolates at the molecular level, where isolates 1 and 2 were identified as strains of Bacillus pumilus, whilst isolate 3 was found to be Bacillus subtilis (Chapter 3). This study further explored the chemical composition of the bacterial extract using …
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Investigation of a deep-sea sediment-derived streptomyces coelicoflavus strain via genomic and metabolomic approaches
… Η προσέγγιση feature-based και ion-identity molecular networking επέτρεψε την προσεγγιστική αναγνώριση γνωστών μεταβολιτών σε μεγάλη κλίμακα (large-scale metabolite annotation) και τη στοχευμένη ιεράρχηση διακριτών μοριακών χαρακτηριστικών (molecular features). Η εκτενής προσέγγιση …
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Genome-guided bioprospecting for novel antibiotic lead compounds.
… probe dimerization are proposed, together with molecular networking strategies that can afford global visualisation and rapid dereplication of extract components, using tandem mass spectrometry fragmentation patterns of parent ions. This project provides an original and robust workflow that …
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Screening of actinobacteria for novel antimalarial compounds
… Using the Global Natural Product Social molecular networking (GNPS) workflow, genome mining, and NMR analysis, it was revealed that the cyclodepsipeptides, valinomycin, montanastatin, and nine other novel analogues were responsible for the high antiplasmodial activity detected. A review …
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Diel patterns of insect herbivory and plant secondary metabolites in understory shrubs on Barro Colorado Island
… (UHPLC), electrospray ionization and molecular fragmentation, and tandem mass spectrometry (MS/MS). Network analyses show that plant secondary metabolites varied greatly in their presence in leaves over the course of several hours, suggesting that ecologically significant differences …