Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"Molecular network"”.
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Synaptic Multimodal Imaging and Molecular Network Inference
… function is reliant on synaptic function – the molecular computation that integrates activity history, chemical environment, and the genetic state of its pre- and post-synaptic neurons to modulate neuron-neuron communication through synaptic plasticity. This computation is performed by the …
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MOLECULAR NETWORK CONTROLLING THE OVULE DEVELOPMENT IN ARABIDOPSIS THALIANA
… provides an excellent tool to understand the molecular mechanism involved in controlling the basic processes like primordia initiation, specification, cell division, expansion and differentiation. This system allows the study of basic developmental process as well as the evolutionary prospect …
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Toughening of a polyester and epoxy molecular network system
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 1997.
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JigCell Model Connector: Building Large Molecular Network Models from Components
The ever-growing size and complexity of molecular network models makes them difficult to construct and understand. Modifying a model that consists of tens of reactions is no easy task. Attempting the same on a model containing hundreds of reactions can seem nearly impossible. We present the JigCell …
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Fundamental limitations between noise and back-action in bio-molecular networks
In an interconnection of two components in a bio-molecular network, noise in the downstream component can be reduced by increasing the magnitude of the down-stream signal. However, this method of reducing noise increases the back-effect to the upstream system, called 'retroactivity', thereby …
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Single-cell approaches reveal functional and molecular heterogeneity in malignant haematopoietic stem cells
… approaches are applied to resolve the molecular mechanisms driving disease in mouse haematopoietic stem cells (HSCs), using JAK2 V617F mutant myeloproliferative neoplasms (MPNs) as a model. This study utilises single-cell gene expression and functional assays to identify a subset of …
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The statistical mechanics of continuous random networks
… molecules is transformed into an amorphous solid network. Being amorphous, local structural properties in such networks vary across the sample. A natural order parameter, resulting from a statistical-mechanical approach, captures information concerning this heterogeneity via a certain joint …
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Temperature and rate dependent finite strain behavior of poly(ethylene terephthalate) and poly(ethylene terephthalate)-glycol above the glass transition temperature
… deformation with two parallel elements: an intermolecular resistance to flow and a resistance due to molecular network interactions.
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Atomistic simulations of elastic-plastic deformation of amorphous polymers
… work, the thermo-mechanical behavior and the molecular-level origins of plastic deformation of an amorphous glassy polymer were studied using atomistic simulations. Understanding of the molecular response will aid the development of physics-based continuum level models for these materials. A …
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Passive, Self-Healable, Dielectric Elastomers for Structural Health Monitoring
… self-healing poly(dimethylsiloxane) via a supra-molecular network of multi-strength hydrogen bonds. The modified poly(dimethylsiloxane) network must be effective in harsh environments, particularly extremely low temperatures, as well as retain the dielectric properties of poly(dimethylsiloxane). …
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Molecular evolution of the p53 network in reptiles
<p>The p53 molecular network is a master regulator of how cells respond to DNA-damaging stresses. Its primary function is to respond to DNA-damage by several options: apoptosis, cellular senescence, and temporary arrest of cellular growth for DNA repair. The p53 network's tight regulation of …
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Extração, caracterização fitoquímica e padronização do extrato das folhas de Passiflora cincinnata para o desenvolvimento de nanoemulsões com potencial hidratante e pró-idade
… were obtained and analyzed by HPLC/MS. A molecular network was generated using the Global Natural Product Social Molecular Networking (GNPS) platform. The antioxidant activity of the 12 extracts was assessed through various tests targeting different stages of the oxidative cascade. For …
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Exploring the molecular diversity and biomedicinal potential of marine invertebrates and South African actinomycetes for tuberculosis drug discovery
… dereplicated using 1H NMR, HR-LCMS with GNPS molecular networking. The extracts were subsequently subjected to an activity-guided isolation process to yield heteronemin from Hyrtios reticulatus extract, and bengamides P and Q from Jaspis splendens extract. A new bengamide derivative was …
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Analysis of the Zebrafish Segmentation Clock
… the position of the new somite boundary. The molecular network that comprises the cyclic genes and their regulation in the PSM is termed the segmentation clock. Retinoic acid (RA) has been previously proposed to be a differentiation signal that acts to arrest the oscillations at the anterior …
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Computational Labeling, Partitioning, and Balancing of Molecular Networks
… in high throughput techniques enable large-scale molecular quantification with high accuracy, including mRNAs, proteins and metabolites. Differential expression of these molecules in case and control samples provides a way to select phenotype-associated molecules with statistically significant …
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Modelling timing in blood cancers
… whilst progressing and the order between these molecular and cellular events may modify prognosis. This thesis addresses the influence of biological event timing on blood cancer progression and clinical outcomes. It first investigates the therapeutic efficacy of p53 restoration in a lymphoma …
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Polymer structure and property studies in elongational rheology, spherulite deformation, and biaxial strain induced crystallization
… of molten polyethylene was sensitive to both molecular weight distribution and shear modification. The effects of molecular weight distribution and shear modification were rationalized from a molecular point of view. A model is proposed which is based on the concept of a molecular network and …
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Cell Size Control And Asymmetric Cell Fates In Start Of The Saccharomyces cerevisiae Cell Cycle
<p>Understanding the molecular and biophysical mechanisms that couple the process of cell growth to cell division is one of the major challenges of modern cell biology. Saccharomyces cerevisiae (budding yeast) has been an important model organism to study the coupling between cell growth and cell …
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Bridging the gap between populations and individuals in the philosophy of medicine
… glance. The third chapter focuses on so-called molecular network reconstruction, a type of mechanistic discovery strategy that leverages large datasets. While it is often difficult to find strong associations between genetic variants and individual health outcomes, this literature suggests that …
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Sequence Dependent Elasticity of DNA
… genetic information; it functions in a complex molecular network that can condense, transcribe, replicate and repair genes. The essential role played by the sequence dependent structure and deformability of DNA in these basic processes of life, has received increasing attention over the past …
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