Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1603 for “"Molecular mechanisms"”.
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Molecular mechanisms regulating implantation
… for a successful implantation. To understand the mechanisms governing these complex interactions and better address the clinical challenges to infertility, it is important to integrate the information gained from these studies. Chapter I presents a detailed analysis of the knowledge gained from …
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Molecular mechanisms of synaptic proteins
… the IgSF21: NRXN2α interaction mechanism at a molecular level will further advance our understanding of the SAM interactome. We describe our valiant efforts to set up an over-expression system for IgSF21. Our work supports the idea that SAMs are not static adhesion molecules. The trans-synaptic …
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MOLECULAR MECHANISMS REGULATING SPINE REMODELLING
N-Cadherin plays an important role during dendrite arborisation, axon guidance and synaptogenesys. In particular, at synaptic sites, it is required for activity-dependent synaptic plasticity and dendritic spine remodeling. Recent studies have shown that N-Cadherin can be cleaved by the …
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Molecular Mechanisms of Itch Sensations
… an early attention due to its severity, the molecular mechanism of itch has not been studied in detail. Itch and pain share common features because they are transmitted by similar neuronal circuits. However, itch is a distinct somatosensation and has opposite characteristics to pain. Itch …
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Molecular mechanisms of synaptic proteins
… the IgSF21: NRXN2α interaction mechanism at a molecular level will further advance our understanding of the SAM interactome. We describe our valiant efforts to set up an over-expression system for IgSF21. Our work supports the idea that SAMs are not static adhesion molecules. The trans-synaptic …
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Molecular mechanisms of cadmium toxic
… stress induced by Cd occurs by different mechanisms depending on cell type and that Ca²⁺ alteration may play an important role in Cd-induced toxicity in HEK 293 cells, while the mitochondrial-cytochrome c dependent pathway is important in Cd toxicity in all three cell lines. Also, the …
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Molecular mechanisms of exosome secretion
… is unclear. My thesis work mainly focused on the molecular mechanisms that control the exocytic trafficking of MVEs and, ultimately, exosome secretion. We found that the conversion of phosphatidylinositol-3-phosphate (PI(3)P) to phosphatidylinositol-4-phosphate (PI(4)P) catalyzed by Myotubularin 1 …
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Molecular Mechanisms of Cell Adhesion
… response of the complex to force, using steered molecular dynamics. Starting from the structure of the complex from the Ig1-Ig2-Ig3 fragment, we first equilibrate the complex in solvent and show that its actual end-to-end length is markedly larger than in the crystal structure. We then show that …
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Molecular mechanisms of KRas4b signaling
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2027-05-01
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Molecular mechanisms of synaptic plasticity
Synaptic plasticity serves as a central molecular mechanism underlying learning and memory formation in the brain. An increase in intracellular calcium concentrations triggered by neuronal activity induces synaptic plasticity, and calmodulin is a key protein that detects the elevated calcium levels …
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Delineating the molecular mechanisms regulating chondrogenesis
Sox9, (SRY-type HMG box), has been shown to play a critical role throughout chondrogenesis. Haploinsufficiency of Sox9 in humans leads to a skeletal malformation syndrome known as campomelic dysplasia. To understand the regulation of Sox9 during chondrogenesis, the developing mouse limb was used to …
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Molecular Mechanisms Controlling Synaptic Vesicle Fusion
SNARE proteins are the engines that drive membrane fusion throughout the cell. They provide this energy by zippering up into a parallel four helix bundle in a thermodynamically favored process. Because the zippering of SNAREs is spontaneous, fusion events occur immediately upon a vesicle …
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Molecular Mechanisms Involved In Krabbe's Disease
La leucodistrofia di Krabbe o a cellule globoidi è un disturbo autosomico recessivo a carico del gene codificante per galactosilcerebrosidase (GALC). GALC è coinvolto nel catabolismo di due lipidi molto prodotti nel processo di formazione della guaina mielinica: galactosilceramide e psicosina. A …
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Two molecular mechanisms of apoptosis resistance
… presented in this dissertation describe two molecular mechanisms of apoptosis resistance. A mouse keratinocyte model system consisting of the benign 308 parental cell line and two malignantly progressed variants (6M90 and 6R90 cells) were used to explore the relationship between reactive …
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Molecular Mechanisms Involved in Chromosome Segregation
Eukaryotic organisms use large and intricate macromolecular machines to accurately pass chromosomes to two daughter cells during cell division. Errors during chromosome segregation are frequently deleterious to the cell and often result in aneuploidy leading to the formation of cancer cells. …
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Molecular Mechanisms Controlling Excitatory Synaptic Transmission
… number and spatial positioning of receptors. The mechanisms governing AMPAR anchoring at postsynaptic sites have been intensely studied for many years, focussing on intracellular interactions with postsynaptic scaffold proteins, however, these interactions do not appear strictly essential to …
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Molecular mechanisms of kinetochore microtubule attachment
… chromosome segregation during mitosis, the macromolecular kinetochore must remain attached to depolymerizing microtubules, which drive poleward chromosome movement. Microtubules are highly dynamic structures that undergo dramatic structural changes during depolymerization. The results presented …
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Unraveling The Molecular Mechanisms Of Insect Diversity
<p>ABSTRACT</p> <p>UNRAVELING THE MOLECULAR MECHANISMS OF INSECT DIVERSITY</p> <p>by</p> <p>STEVEN MICHAEL HRYCAJ</p> <p>April 2010</p> <p>Advisor: Dr. Aleksandar Popadic´</p> <p>Major: Biological Sciences</p> <p>Degree: Doctor of Philosophy</p> <p>While it has long been recognized that the …
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Deciphering AXL-Driven Molecular Mechanisms of EMT
Pages xviii-xix are misnumbered as pages xix-xx.
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Molecular mechanisms of Kruppel-like Factor 4
… stem cells. This dissertation focuses on the molecular mechanisms of KLF4-mediated transcription, both in the context of KLF4-mediated activation and KLF4-mediated repression. I demonstrate that the N-terminal transactivation domain of KLF4 recruits the co-activator p300/CBP to the promoter of …
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