Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 549 for “"Molecular mechanism"”.
-
Molecular Mechanism of Parvovirus Infection
… are composed of two parts: 1) investigating the molecular mechanisms underlying cytopathic effects induced during infections of parvovirus B19 (B19V) and minute virus of canines (MVC); 2) identifying the role of EpoR signaling in supporting B19V replication in erythroid of progenitor cells. To …
-
Defining Molecular Mechanism of Egress in Cryptosporidium
… to parasite propagation. However, the molecular mechanisms behind egress remain unknown. We propose to study the genes upregulated in the intracellular stages of infection using a novel silencing method developed in our lab. Our aim was to analyze the C. parvum orthologues of molecules …
-
Investigating the Molecular Mechanism of Ribosome Recycling
… X-ray crystallography and cryo-EM to dissect the mechanisms of ribosome inhibition by amikacin and the rescue of stalled ribosome through HflXr-mediated recycling. Amikacin interferes with tRNA translocation, release factor-mediated peptidyl-tRNA hydrolysis, and ribosome recycling, traits …
-
The Molecular Mechanism of Break Induced Replication
… of the chromosome. The cell has evolved several mechanisms to repair DSBs, one of which is break-induced replication (BIR). BIR repair of DSBs occurs through invasion of one end of the broken chromosome into a homologous template followed by processive replication of DNA from the donor molecule. …
-
Molecular Mechanism of Zipper Interacting Protein Kinase
… mutations of ZIPK was used to determine the mechanism of cellular transport. This was done to address the difference in cellular localization between human and murine cells. The localization of human ZIPK is dictated by nuclear localization sequence 2 (NLS2) and the phosphorylation state of …
-
Molecular mechanism of KAP1-dependent transcriptional silencing
… and adjacent genes. To understand the molecular basis of KAP1-dependent transcriptional regulation I determined the crystal structure of the RBCC domain of KAP1. My structural and biophysical data demonstrate that KAP1 forms antiparallel dimers, which further assemble into tetramers and …
-
Molecular Mechanism of VanB Phenotype-VanA VRE
"목적: 장구균의 vancomycin 내성의 표현형은 VanA, VanB, VanC, VanD, VanE 및 VanG의 6가지형이 있으며, 이중 VanA와 VanB형이 임상적으로 의미가 있다. VanA형은 vancomycin과 teicoplanin에 내성을 나타내며, VanB형은 vancomycin에는 내성이나 teicoplanin에는 감수성을 보인다. 그러나, 최근 vancomycin에는 내성이나 teicoplanin에는 감수성인 vanA형 vancomycin 내성 장구균(Vancomycin-resistant …
-
Molecular mechanism of Trypanosoma brucei Aquaglyceroporin 2
… charged under physiological conditions. The molecular mechanism of the TbAQP2-linked drug uptake in trypanosomes is controversial. Suggested mechanisms include transport through the unconventional TbAQP2 pore and indirect uptake via endocytosis of the TbAQP2-drug complexes. The physiological …
-
The Molecular Mechanism of Platelet Activation in Inflammation
… extracellularly, acting as damage-associated molecular patterns (DAMPs) that contribute to inflammation and thrombosis. This study investigates the role of extracellular histones in platelet activation, exploring their pro-thrombotic effects and the molecular pathways involved. Using flow …
-
Molecular Mechanism of Tetraspanin CD9 Mediated Cell Motility
… adhesive functions such as cell migration. The mechanisms underlying CD9 mediated cell migration are not known. In the current study, we investigated the molecular basis for the CD9 promoted cell migration. Our findings show that the phosphatidylinositol-3 kinase (PI-3K) inhibitors, wortamannin …
-
Domain swapping as a molecular mechanism in amyloidosis
… fibrils. In the present work the role of this mechanism is investigated. Two variants of wild type and L68Q cystatin C, respectively, with disulfide bonds at positions selected to inhibit domain swapping have been produced. It was observed that the capacity of the four proteins to form dimers, …
-
Molecular mechanism of magnesium transport in epithelial cells
… and parietal cells and (b) to characterise the molecular mechanism of Mg 2 transport using fluorimetric and spectroscopic studies. The results have shown that application of either cholecystokinin-octapeptide (CCK-8) or acetylcholine (ACh) to rat pancreatic segments can result in marked …
-
MOLECULAR MECHANISM OF HIV-1 TAT INDUCED NEURONAL DYSFUNCTION
… their functions through deregulation of several molecular pathways that can cause mitochondrial damage (such as depletion of mitochondrial calcium and release of ROS), inhibition of axonal transport leading to prevent neuronal communications or loss of long-term potentiation (LTP). Interestingly, …
-
Identifying the Molecular Mechanism of TAZ-Induced Lung Tumorigenesis
… transformation and tumorigenesis. However, the molecular mechanism underlying TAZ-induced tumorigenesis remains largely unknown. In this study, we first established an in vivo xenograft mouse model by overexpressing the constitutively active TAZ-S89A in E10 (mouse) and HBE135 (human) …
-
UNDERSTANDING THE MOLECULAR MECHANISM LINKING ATM TO METABOLIC REGULATION.
… to ionizing radiation and premature aging. The molecular basis of A-T is loss of function of the gene encoding A-T-mutated (ATM), a serine/threonine kinase that acts as a master regulator of the DNA damage response, leaving A-T patients highly predisposed to cancers. In addition to its classical …
-
Molecular Mechanism of Aurora-A Kinase in Human Oncogenesis
… and activity are cell cycle regulated. The mechanism of Aurora-A upregulation at onset of mitosis is largely unknown. We demonstrated, for the first time, that transcription factor E2F3 directly binds to Aurora-A promoter and tightly regulates Aurora-A expression during G2/M phase. Moreover, …
-
Investigation of the Molecular Mechanism for Cerebral Cavernous Malformations
… CCM lesion genesis may follow a two-hit genetic mechanism. To investigate this hypothesis and determine the molecular mechanism underlying CCM pathogeneis, we used resected human lesion samples to identify biallelic somatic and germline mutations that are specific to the lesion endothelium. …
-
Molecular mechanism of ligand induced regulation of cannabinoid receptors
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-12-01
Page 1 of 28